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Protein

Ferric enterobactin receptor

Gene

pfeA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specific receptor for the siderophore ferric enterobactin.

GO - Molecular functioni

  • enterobactin transmembrane transporter activity Source: PseudoCAP
  • iron ion binding Source: InterPro
  • siderophore uptake transmembrane transporter activity Source: PseudoCAP
  • signaling receptor activity Source: InterPro

GO - Biological processi

  • enterobactin transport Source: PseudoCAP
  • iron ion homeostasis Source: UniProtKB-KW
  • siderophore transport Source: PseudoCAP

Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-2728-MONOMER

Protein family/group databases

TCDBi1.B.14.1.5 the outer membrane receptor (omr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric enterobactin receptor
Gene namesi
Name:pfeA
Ordered Locus Names:PA2688
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA2688

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • outer membrane Source: PseudoCAP

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003476926 – 746Ferric enterobactin receptorAdd BLAST721

Proteomic databases

PaxDbiQ05098
PRIDEiQ05098

Expressioni

Inductioni

By iron and enterobactin.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA2688

Structurei

Secondary structure

1746
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi45 – 48Combined sources4
Helixi49 – 51Combined sources3
Beta strandi55 – 59Combined sources5
Helixi60 – 65Combined sources6
Beta strandi69 – 71Combined sources3
Helixi73 – 76Combined sources4
Beta strandi82 – 85Combined sources4
Turni92 – 95Combined sources4
Beta strandi98 – 101Combined sources4
Helixi106 – 108Combined sources3
Beta strandi109 – 113Combined sources5
Helixi120 – 123Combined sources4
Helixi143 – 145Combined sources3
Beta strandi146 – 153Combined sources8
Helixi154 – 160Combined sources7
Beta strandi165 – 173Combined sources9
Beta strandi181 – 193Combined sources13
Beta strandi199 – 225Combined sources27
Turni230 – 236Combined sources7
Helixi242 – 244Combined sources3
Beta strandi254 – 267Combined sources14
Beta strandi272 – 286Combined sources15
Beta strandi292 – 294Combined sources3
Helixi298 – 303Combined sources6
Beta strandi309 – 323Combined sources15
Beta strandi328 – 343Combined sources16
Beta strandi345 – 348Combined sources4
Helixi349 – 351Combined sources3
Beta strandi361 – 380Combined sources20
Beta strandi382 – 400Combined sources19
Turni402 – 405Combined sources4
Turni410 – 412Combined sources3
Beta strandi425 – 443Combined sources19
Beta strandi446 – 457Combined sources12
Turni458 – 460Combined sources3
Beta strandi461 – 475Combined sources15
Beta strandi478 – 489Combined sources12
Turni493 – 496Combined sources4
Beta strandi501 – 506Combined sources6
Beta strandi516 – 519Combined sources4
Beta strandi527 – 540Combined sources14
Beta strandi543 – 560Combined sources18
Beta strandi565 – 567Combined sources3
Helixi573 – 575Combined sources3
Beta strandi579 – 603Combined sources25
Beta strandi606 – 620Combined sources15
Turni621 – 623Combined sources3
Beta strandi626 – 628Combined sources3
Beta strandi632 – 641Combined sources10
Beta strandi644 – 656Combined sources13
Helixi673 – 676Combined sources4
Beta strandi682 – 694Combined sources13
Beta strandi697 – 705Combined sources9
Beta strandi737 – 745Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5M9BX-ray2.12A26-746[»]
5MZSX-ray2.67A26-746[»]
5NC3X-ray2.57A26-746[»]
5NC4X-ray2.80A26-746[»]
ProteinModelPortaliQ05098
SMRiQ05098
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi39 – 44TonB box6
Motifi729 – 746TonB C-terminal boxAdd BLAST18

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4107RNH Bacteria
COG4771 LUCA
HOGENOMiHOG000276827
InParanoidiQ05098
KOiK19611
OMAiNESGRTW
PhylomeDBiQ05098

Family and domain databases

Gene3Di2.170.130.10, 1 hit
2.40.170.20, 1 hit
InterProiView protein in InterPro
IPR012910 Plug_dom
IPR037066 Plug_dom_sf
IPR000531 TonB-dep_rcpt_b-brl
IPR036942 TonB_rcpt_b-brl_sf
IPR010917 TonB_rcpt_CS
IPR010105 TonB_sidphr_rcpt
PfamiView protein in Pfam
PF07715 Plug, 1 hit
PF00593 TonB_dep_Rec, 1 hit
TIGRFAMsiTIGR01783 TonB-siderophor, 1 hit
PROSITEiView protein in PROSITE
PS01156 TONB_DEPENDENT_REC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRALPAVP FLLLSSCLLA NAVHAAGQGD GSVIELGEQT VVATAQEETK
60 70 80 90 100
QAPGVSIITA EDIAKRPPSN DLSQIIRTMP GVNLTGNSSS GQRGNNRQID
110 120 130 140 150
IRGMGPENTL ILVDGKPVSS RNSVRYGWRG ERDSRGDTNW VPADQVERIE
160 170 180 190 200
VIRGPAAARY GNGAAGGVVN IITKQAGAET HGNLSVYSNF PQHKAEGASE
210 220 230 240 250
RMSFGLNGPL TENLSYRVYG NIAKTDSDDW DINAGHESNR TGKQAGTLPA
260 270 280 290 300
GREGVRNKDI DGLLSWRLTP EQTLEFEAGF SRQGNIYTGD TQNTNSNNYV
310 320 330 340 350
KQMLGHETNR MYRETYSVTH RGEWDFGSSL AYLQYEKTRN SRINEGLAGG
360 370 380 390 400
TEGIFDPNNA GFYTATLRDL TAHGEVNLPL HLGYEQTLTL GSEWTEQKLD
410 420 430 440 450
DPSSNTQNTE EGGSIPGLAG KNRSSSSSAR IFSLFAEDNI ELMPGTMLTP
460 470 480 490 500
GLRWDHHDIV GDNWSPSLNL SHALTERVTL KAGIARAYKA PNLYQLNPDY
510 520 530 540 550
LLYSRGQGCY GQSTSCYLRG NDGLKAETSV NKELGIEYSH DGLVAGLTYF
560 570 580 590 600
RNDYKNKIES GLSPVDHASG GKGDYANAAI YQWENVPKAV VEGLEGTLTL
610 620 630 640 650
PLADGLKWSN NLTYMLQSKN KETGDVLSVT PRYTLNSMLD WQATDDLSLQ
660 670 680 690 700
ATVTWYGKQK PKKYDYHGDR VTGSANDQLS PYAIAGLGGT YRLSKNLSLG
710 720 730 740
AGVDNLFDKR LFRAGNAQGV VGIDGAGAAT YNEPGRTFYT SLTASF
Length:746
Mass (Da):80,968
Last modified:June 1, 1994 - v1
Checksum:iADD4FB0CB22C3251
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98033 Genomic DNA Translation: AAA25928.1
AE004091 Genomic DNA Translation: AAG06076.1
PIRiA40636
RefSeqiNP_251378.1, NC_002516.2
WP_003113404.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG06076; AAG06076; PA2688
GeneIDi882784
KEGGipae:PA2688
PATRICifig|208964.12.peg.2813

Similar proteinsi

Entry informationi

Entry nameiPFEA_PSEAE
AccessioniPrimary (citable) accession number: Q05098
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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