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Q05097 (PA1L_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
PA-I galactophilic lectin

Short name=PA-IL
Alternative name(s):
Galactose-binding lectin
Gene names
Name:lecA
Synonyms:pa1L
Ordered Locus Names:PA2570
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length122 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.

Subcellular location

Cytoplasm. Periplasm. Cell surface. Note: Low exposure on the cell surface.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 122121PA-I galactophilic lectin
PRO_0000058158

Secondary structure

................... 122
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q05097 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 1DC739390388A451

FASTA12212,893
        10         20         30         40         50         60 
MAWKGEVLAN NEAGQVTSII YNPGDVITIV AAGWASYGPT QKWGPQGDRE HPDQGLICHD 

        70         80         90        100        110        120 
AFCGALVMKI GNSGTIPVNT GLFRWVAPNN VQGAITLIYN DVPGTYGNNS GSFSVNIGKD 


QS 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the amino acid sequence of the Pseudomonas aeruginosa galactophilic PA-I lectin."
Avichezer D., Katcoff D.J., Garber N.C., Gilboa-Garber N.
J. Biol. Chem. 267:23023-23027(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-31.
Strain: ATCC 33347.
[2]"Pseudomonas aeruginosa PA-I lectin gene molecular analysis and expression in Escherichia coli."
Avichezer D., Gilboa-Garber N., Garber N.C., Katcoff D.J.
Biochim. Biophys. Acta 1218:11-20(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"The Pseudomonas aeruginosa lectins PA-1L and PA-2L are controlled by quorum sensing and by RpoS."
Winzer K., Falconer C., Diggle S.P., Garber N.C., Camara M., Williams P.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen."
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. expand/collapse author list , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.
Nature 406:959-964(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X65933 Genomic DNA. Translation: CAA46728.1.
AF229814 Genomic DNA. Translation: AAF70459.1.
AE004091 Genomic DNA. Translation: AAG05958.1.
PIRS45300.
RefSeqNP_251260.1. NC_002516.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1L7LX-ray1.50A2-121[»]
1OKOX-ray1.60A/B/C/D2-122[»]
1UOJX-ray2.40A/B/C/D2-122[»]
2VXJX-ray1.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X2-122[»]
2WYFX-ray2.40A/B/C/D/E/F/G/H2-122[»]
3ZYBX-ray2.29A/B/C/D/E/F/G/H1-122[»]
3ZYFX-ray1.94A/B/C/D1-122[»]
3ZYHX-ray1.50A/B1-122[»]
4A6SX-ray2.15A/B/C/D2-122[»]
4AL9X-ray1.75A/B/C/D/E/F/G/H2-122[»]
4LJHX-ray1.45A/B/C/D1-122[»]
4LK6X-ray2.86A/B/C/D/E/F/G/H/I/J/K/L2-122[»]
4LK7X-ray1.76A/B/C/D2-122[»]
4LKDX-ray2.31A/B/C/D/E/F/G/H2-122[»]
4LKEX-ray1.65A/B/C/D2-122[»]
4LKFX-ray1.64A/B2-122[»]
ProteinModelPortalQ05097.
SMRQ05097. Positions 2-122.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA2570.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID882335.
KEGGpae:PA2570.

Organism-specific databases

PseudoCAPPA2570.

Phylogenomic databases

eggNOGNOG123349.
HOGENOMHOG000247286.
OMAIVAKGWI.
OrthoDBEOG6PZXD0.
ProtClustDBCLSK546878.

Family and domain databases

Gene3D2.60.120.430. 1 hit.
InterProIPR008979. Galactose-bd-like.
IPR012905. PA-IL.
[Graphical view]
PfamPF07828. PA-IL. 1 hit.
[Graphical view]
PIRSFPIRSF020485. PA-IL. 1 hit.
SUPFAMSSF49785. SSF49785. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ05097.

Entry information

Entry namePA1L_PSEAE
AccessionPrimary (citable) accession number: Q05097
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references