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Q05097

- PA1L_PSEAE

UniProt

Q05097 - PA1L_PSEAE

Protein

PA-I galactophilic lectin

Gene

lecA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.

    GO - Biological processi

    1. cellular component movement Source: PseudoCAP
    2. heterophilic cell-cell adhesion Source: PseudoCAP

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PA-I galactophilic lectin
    Short name:
    PA-IL
    Alternative name(s):
    Galactose-binding lectin
    Gene namesi
    Name:lecA
    Synonyms:pa1L
    Ordered Locus Names:PA2570
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA2570.

    Subcellular locationi

    Cytoplasm. Periplasm. Cell surface
    Note: Low exposure on the cell surface.

    GO - Cellular componenti

    1. cell surface Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-SubCell
    3. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 122121PA-I galactophilic lectinPRO_0000058158Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA2570.

    Structurei

    Secondary structure

    1
    122
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 86
    Beta strandi15 – 217
    Beta strandi27 – 4115
    Beta strandi46 – 483
    Beta strandi65 – 706
    Beta strandi81 – 855
    Beta strandi93 – 997
    Helixi106 – 1083
    Beta strandi110 – 11910

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1L7LX-ray1.50A2-122[»]
    1OKOX-ray1.60A/B/C/D2-122[»]
    1UOJX-ray2.40A/B/C/D2-122[»]
    2VXJX-ray1.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X2-122[»]
    2WYFX-ray2.40A/B/C/D/E/F/G/H2-122[»]
    3ZYBX-ray2.29A/B/C/D/E/F/G/H1-122[»]
    3ZYFX-ray1.94A/B/C/D1-122[»]
    3ZYHX-ray1.50A/B1-122[»]
    4A6SX-ray2.15A/B/C/D2-122[»]
    4AL9X-ray1.75A/B/C/D/E/F/G/H2-122[»]
    4LJHX-ray1.45A/B/C/D1-122[»]
    4LK6X-ray2.86A/B/C/D/E/F/G/H/I/J/K/L2-122[»]
    4LK7X-ray1.76A/B/C/D2-122[»]
    4LKDX-ray2.31A/B/C/D/E/F/G/H2-122[»]
    4LKEX-ray1.65A/B/C/D2-122[»]
    4LKFX-ray1.64A/B2-122[»]
    ProteinModelPortaliQ05097.
    SMRiQ05097. Positions 2-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ05097.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG123349.
    HOGENOMiHOG000247286.
    OMAiIVAKGWI.
    OrthoDBiEOG6PZXD0.

    Family and domain databases

    Gene3Di2.60.120.430. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR012905. PA-IL.
    [Graphical view]
    PfamiPF07828. PA-IL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF020485. PA-IL. 1 hit.
    SUPFAMiSSF49785. SSF49785. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05097-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWKGEVLAN NEAGQVTSII YNPGDVITIV AAGWASYGPT QKWGPQGDRE    50
    HPDQGLICHD AFCGALVMKI GNSGTIPVNT GLFRWVAPNN VQGAITLIYN 100
    DVPGTYGNNS GSFSVNIGKD QS 122
    Length:122
    Mass (Da):12,893
    Last modified:January 23, 2007 - v2
    Checksum:i1DC739390388A451
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65933 Genomic DNA. Translation: CAA46728.1.
    AF229814 Genomic DNA. Translation: AAF70459.1.
    AE004091 Genomic DNA. Translation: AAG05958.1.
    PIRiS45300.
    RefSeqiNP_251260.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG05958; AAG05958; PA2570.
    GeneIDi882335.
    KEGGipae:PA2570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65933 Genomic DNA. Translation: CAA46728.1 .
    AF229814 Genomic DNA. Translation: AAF70459.1 .
    AE004091 Genomic DNA. Translation: AAG05958.1 .
    PIRi S45300.
    RefSeqi NP_251260.1. NC_002516.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1L7L X-ray 1.50 A 2-122 [» ]
    1OKO X-ray 1.60 A/B/C/D 2-122 [» ]
    1UOJ X-ray 2.40 A/B/C/D 2-122 [» ]
    2VXJ X-ray 1.90 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X 2-122 [» ]
    2WYF X-ray 2.40 A/B/C/D/E/F/G/H 2-122 [» ]
    3ZYB X-ray 2.29 A/B/C/D/E/F/G/H 1-122 [» ]
    3ZYF X-ray 1.94 A/B/C/D 1-122 [» ]
    3ZYH X-ray 1.50 A/B 1-122 [» ]
    4A6S X-ray 2.15 A/B/C/D 2-122 [» ]
    4AL9 X-ray 1.75 A/B/C/D/E/F/G/H 2-122 [» ]
    4LJH X-ray 1.45 A/B/C/D 1-122 [» ]
    4LK6 X-ray 2.86 A/B/C/D/E/F/G/H/I/J/K/L 2-122 [» ]
    4LK7 X-ray 1.76 A/B/C/D 2-122 [» ]
    4LKD X-ray 2.31 A/B/C/D/E/F/G/H 2-122 [» ]
    4LKE X-ray 1.65 A/B/C/D 2-122 [» ]
    4LKF X-ray 1.64 A/B 2-122 [» ]
    ProteinModelPortali Q05097.
    SMRi Q05097. Positions 2-122.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA2570.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG05958 ; AAG05958 ; PA2570 .
    GeneIDi 882335.
    KEGGi pae:PA2570.

    Organism-specific databases

    PseudoCAPi PA2570.

    Phylogenomic databases

    eggNOGi NOG123349.
    HOGENOMi HOG000247286.
    OMAi IVAKGWI.
    OrthoDBi EOG6PZXD0.

    Miscellaneous databases

    EvolutionaryTracei Q05097.

    Family and domain databases

    Gene3Di 2.60.120.430. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR012905. PA-IL.
    [Graphical view ]
    Pfami PF07828. PA-IL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF020485. PA-IL. 1 hit.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the amino acid sequence of the Pseudomonas aeruginosa galactophilic PA-I lectin."
      Avichezer D., Katcoff D.J., Garber N.C., Gilboa-Garber N.
      J. Biol. Chem. 267:23023-23027(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-31.
      Strain: ATCC 33347.
    2. "Pseudomonas aeruginosa PA-I lectin gene molecular analysis and expression in Escherichia coli."
      Avichezer D., Gilboa-Garber N., Garber N.C., Katcoff D.J.
      Biochim. Biophys. Acta 1218:11-20(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "The Pseudomonas aeruginosa lectins PA-1L and PA-2L are controlled by quorum sensing and by RpoS."
      Winzer K., Falconer C., Diggle S.P., Garber N.C., Camara M., Williams P.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiPA1L_PSEAE
    AccessioniPrimary (citable) accession number: Q05097
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3