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Protein

Unconventional myosin-Ib

Gene

Myo1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi108 – 115ATPSequence analysis8

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin-dependent ATPase activity Source: RGD
  • actin filament binding Source: RGD
  • ATP binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB
  • microfilament motor activity Source: UniProtKB
  • motor activity Source: UniProtKB
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

GO - Biological processi

  • actin filament-based movement Source: UniProtKB
  • actin filament bundle assembly Source: UniProtKB
  • nervous system development Source: RGD
  • post-Golgi vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ib
Alternative name(s):
Myosin I alpha
Short name:
MMI-alpha
Short name:
MMIa
Myosin heavy chain myr 1
Gene namesi
Name:Myo1b
Synonyms:Myo1a, Myr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi70994. Myo1b.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: Ensembl
  • apical part of cell Source: RGD
  • brush border Source: RGD
  • cell-cell adherens junction Source: Ensembl
  • cell periphery Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • early endosome Source: Ensembl
  • endosome membrane Source: Ensembl
  • extracellular exosome Source: Ensembl
  • filopodium Source: UniProtKB
  • myosin complex Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: Ensembl
  • plasma membrane Source: UniProtKB
  • trans-Golgi network membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234441 – 1136Unconventional myosin-IbAdd BLAST1136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ05096.
PeptideAtlasiQ05096.
PRIDEiQ05096.

PTM databases

iPTMnetiQ05096.
PhosphoSitePlusiQ05096.

Expressioni

Gene expression databases

ExpressionAtlasiQ05096. baseline and differential.
GenevisibleiQ05096. RN.

Interactioni

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: RGD
  • calmodulin binding Source: UniProtKB

Protein-protein interaction databases

MINTiMINT-4563663.
STRINGi10116.ENSRNOP00000061523.

Structurei

Secondary structure

11136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni10 – 13Combined sources4
Helixi20 – 22Combined sources3
Helixi28 – 40Combined sources13
Beta strandi45 – 48Combined sources4
Beta strandi51 – 55Combined sources5
Helixi66 – 72Combined sources7
Turni77 – 79Combined sources3
Beta strandi80 – 82Combined sources3
Helixi84 – 98Combined sources15
Beta strandi102 – 109Combined sources8
Helixi112 – 128Combined sources17
Helixi133 – 144Combined sources12
Helixi146 – 153Combined sources8
Beta strandi166 – 174Combined sources9
Beta strandi180 – 188Combined sources9
Helixi193 – 196Combined sources4
Helixi206 – 214Combined sources9
Helixi217 – 222Combined sources6
Helixi229 – 231Combined sources3
Helixi247 – 260Combined sources14
Helixi265 – 281Combined sources17
Beta strandi299 – 301Combined sources3
Helixi304 – 313Combined sources10
Helixi317 – 325Combined sources9
Beta strandi326 – 328Combined sources3
Beta strandi331 – 334Combined sources4
Beta strandi337 – 339Combined sources3
Helixi342 – 370Combined sources29
Beta strandi381 – 387Combined sources7
Beta strandi395 – 397Combined sources3
Helixi399 – 429Combined sources31
Helixi442 – 450Combined sources9
Turni452 – 454Combined sources3
Helixi456 – 465Combined sources10
Beta strandi466 – 468Combined sources3
Helixi472 – 482Combined sources11
Turni492 – 494Combined sources3
Beta strandi507 – 514Combined sources8
Beta strandi517 – 522Combined sources6
Helixi526 – 530Combined sources5
Helixi536 – 543Combined sources8
Helixi548 – 553Combined sources6
Helixi555 – 557Combined sources3
Helixi570 – 586Combined sources17
Beta strandi588 – 596Combined sources9
Helixi609 – 619Combined sources11
Helixi621 – 629Combined sources9
Beta strandi633 – 637Combined sources5
Helixi638 – 645Combined sources8
Turni650 – 655Combined sources6
Helixi660 – 670Combined sources11
Beta strandi677 – 680Combined sources4
Beta strandi682 – 688Combined sources7
Helixi690 – 728Combined sources39

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L79X-ray2.30A1-728[»]
ProteinModelPortaliQ05096.
SMRiQ05096.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 701Myosin motorAdd BLAST687
Domaini704 – 729IQ 1PROSITE-ProRule annotationAdd BLAST26
Domaini730 – 750IQ 2PROSITE-ProRule annotationAdd BLAST21
Domaini750 – 778IQ 3PROSITE-ProRule annotationAdd BLAST29
Domaini780 – 807IQ 4PROSITE-ProRule annotationAdd BLAST28
Domaini808 – 837IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini837 – 866IQ 6PROSITE-ProRule annotationAdd BLAST30
Domaini952 – 1136TH1PROSITE-ProRule annotationAdd BLAST185

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni592 – 599Actin-bindingSequence analysis8

Sequence similaritiesi

Contains 6 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiQ05096.
KOiK10356.
OMAiGHERKTK.
OrthoDBiEOG091G0136.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50096. IQ. 5 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: Q05096-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKKEVKSSL LDNMIGVGDT VLLEPLNEET FIDNLKKRFD HNEIYTYIGS
60 70 80 90 100
VVISVNPYRS LPIYSPEKVE DYRNRNFYEL SPHIFALSDE AYRSLRDQDK
110 120 130 140 150
DQCILITGES GAGKTEASKL VMSYVAAVCG KGAEVNQVKE QLLQSTPVLE
160 170 180 190 200
AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP LGGVISNYLL EKSRVVKQPR
210 220 230 240 250
GERNFHVFYQ LLSGASEELL HKLKLERDFS RYNYLSLDSA KVNGVDDAAN
260 270 280 290 300
FRTVRNAMQI VGFSDPEAES VLEVVAAVLK LGNIEFKPES RMNGLDESKI
310 320 330 340 350
KDKNELKEIC ELTSIDQVVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD
360 370 380 390 400
ALAKNLYSRL FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE
410 420 430 440 450
QFIINYCNEK LQQIFIELTL KEEQEEYIRE DIEWTHIDYF NNAIICDLIE
460 470 480 490 500
NNTNGILAML DEECLRPGTV TDETFLEKLN QVCATHQHFE SRMSKCSRFL
510 520 530 540 550
NDTTLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ AMWKAGHALI
560 570 580 590 600
KSLFPEGNPA KVNLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND
610 620 630 640 650
KKAAHIFSES LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK
660 670 680 690 700
QTWPHWKGPA RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFQLEDLR
710 720 730 740 750
KQRLEDLATL IQKIYRGWKC RTHFLLMKRS QVVIAAWYRR YAQQKRYQQI
760 770 780 790 800
KSSALVIQSY IRGWKARKIL RELKHQKRCK EAATTIAAYW HGTQARKERR
810 820 830 840 850
RLKDEARNKH AIAVIWAFWL GSKARRELKR LKEEARRKHA VAVIWAYWLG
860 870 880 890 900
LKVRREYRKF FRANAGKKIY EFTLQRIVQK YLLEMKNKMP SLSPIDKNWP
910 920 930 940 950
SRPYLFLDST HKELKRIFHL WRCKKYRDQF TDQQKLIYEE KLEASELFKD
960 970 980 990 1000
KKALYPSSVG QPFQGAYLEI NKNPKYKKLK DAIEEKIIIA EVVNKINRAN
1010 1020 1030 1040 1050
GKSTSRIFLL TNNNLLLADQ KSGQIKSEVP LVDVTKVSMS SQNDGFFAVH
1060 1070 1080 1090 1100
LKEGSEAASK GDFLFSSDHL IEMATKLYRT TLSQTKQKLN IEISDEFLVQ
1110 1120 1130
FRQDKVCVKF IQGNQKNGSV PTCKRKNNRL LEVAVP
Length:1,136
Mass (Da):131,918
Last modified:November 1, 1996 - v1
Checksum:i69D6C2A84E9070E2
GO
Isoform B (identifier: Q05096-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     794-823: Missing.

Show »
Length:1,106
Mass (Da):128,301
Checksum:i16243ECD22FD4B67
GO
Isoform C (identifier: Q05096-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     794-852: Missing.

Show »
Length:1,077
Mass (Da):124,770
Checksum:i63D984F5A7B9443F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003349794 – 852Missing in isoform C. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_003348794 – 823Missing in isoform B. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68199 mRNA. Translation: CAA48287.1.
PIRiA45439.
C45439.
RefSeqiNP_446438.1. NM_053986.1. [Q05096-1]
UniGeneiRn.36339.

Genome annotation databases

EnsembliENSRNOT00000068433; ENSRNOP00000061523; ENSRNOG00000048152. [Q05096-1]
GeneIDi117057.
KEGGirno:117057.
UCSCiRGD:70994. rat. [Q05096-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68199 mRNA. Translation: CAA48287.1.
PIRiA45439.
C45439.
RefSeqiNP_446438.1. NM_053986.1. [Q05096-1]
UniGeneiRn.36339.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4L79X-ray2.30A1-728[»]
ProteinModelPortaliQ05096.
SMRiQ05096.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4563663.
STRINGi10116.ENSRNOP00000061523.

PTM databases

iPTMnetiQ05096.
PhosphoSitePlusiQ05096.

Proteomic databases

PaxDbiQ05096.
PeptideAtlasiQ05096.
PRIDEiQ05096.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068433; ENSRNOP00000061523; ENSRNOG00000048152. [Q05096-1]
GeneIDi117057.
KEGGirno:117057.
UCSCiRGD:70994. rat. [Q05096-1]

Organism-specific databases

CTDi4430.
RGDi70994. Myo1b.

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
HOVERGENiHBG062373.
InParanoidiQ05096.
KOiK10356.
OMAiGHERKTK.
OrthoDBiEOG091G0136.

Miscellaneous databases

PROiQ05096.

Gene expression databases

ExpressionAtlasiQ05096. baseline and differential.
GenevisibleiQ05096. RN.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 6 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50096. IQ. 5 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1B_RAT
AccessioniPrimary (citable) accession number: Q05096
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.