Reviewed,
UniProtKB/Swiss-Prot Q05084 (ICA69_HUMAN)
Last modified
November 3, 2009.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Islet cell autoantigen 1 Alternative name(s): 69 kDa islet cell autoantigen ICA69 Islet cell autoantigen p69 Short name=ICAp69 Short name=p69 | ||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 483 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play a role in neurotransmitter secretion By similarity. |
| Subcellular location | Cytoplasm › cytosol. Golgi apparatus membrane; Peripheral membrane protein Potential. Cytoplasmic vesicle › secretory vesicle membrane; Peripheral membrane protein Potential. Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Peripheral membrane protein Potential. Note: Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules. |
| Tissue specificity | Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid. |
| Involvement in disease | Identified as an autoantigen in insulin-dependent diabetes mellitus. |
| Sequence similarities | Contains 1 AH domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Neurotransmitter transport Transport |
| Cellular component | Cell junction Cytoplasm Cytoplasmic vesicle Golgi apparatus Membrane Synapse |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | neurotransmitter transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | Golgi membrane Ref.6 Inferred from direct assay. Source: UniProtKB cell junctionInferred from electronic annotation. Source: UniProtKB-KW cytosolInferred from sequence or structural similarity. Source: UniProtKB extrinsic to membraneInferred from electronic annotation. Source: UniProtKB-SubCell secretory granule membrane Ref.6Inferred from direct assay. Source: UniProtKB synaptic vesicle membraneInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CNTF | P26441 | 1 | EBI-1046751,EBI-1050897 | |
| KRT33B | Q14525 | 1 | EBI-1046751,EBI-1049638 | |
| MKKS | Q9HB66 | 1 | EBI-1046751,EBI-1054754 | |
| STK16 | O75716 | 1 | EBI-1046751,EBI-1046308 |
Sequence annotation (Features)
Sequences
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References
Cross-references
Entry information
| Entry name | ICA69_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q05084 Secondary accession number(s): A8K7U1, P78506, Q13824 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


