ID   FABI_ANASP              Reviewed;         258 AA.
AC   Q05069;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=Enoyl-[acyl-carrier-protein] reductase [NADH];
DE            EC=1.3.1.9;
DE   AltName: Full=NADH-dependent enoyl-ACP reductase;
GN   Name=fabI; OrderedLocusNames=all4391;
OS   Anabaena sp. (strain PCC 7120).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=93308081; PubMed=8391534;
RA   Wei T.-F., Ramasubramanian T.S., Pu F., Golden J.W.;
RT   "Anabaena sp. strain PCC 7120 bifA gene encoding a sequence-specific
RT   DNA-binding protein cloned by in vivo transcriptional interference
RT   selection.";
RL   J. Bacteriol. 175:4025-4035(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21595285; PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T.,
RA   Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA   Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M.,
RA   Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- CATALYTIC ACTIVITY: Acyl-[acyl-carrier-protein] + NAD(+) = trans-
CC       2,3-dehydroacyl-[acyl-carrier-protein] + NADH.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family. FabI subfamily.
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DR   EMBL; L10036; AAD04184.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000019; BAB76090.1; ALT_INIT; Genomic_DNA.
DR   PIR; AG2354; AG2354.
DR   RefSeq; NP_488431.1; -.
DR   HSSP; P29132; 1DFI.
DR   GeneID; 1107992; -.
DR   GenomeReviews; BA000019_GR; all4391.
DR   KEGG; ana:all4391; -.
DR   HOGENOM; Q05069; -.
DR   BioCyc; NSP103690:ALL4391-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NAD...; IEA:EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR014358; Enoyl-ACP_Rdtase_NADH.
DR   InterPro; IPR002347; Glc/ribitol_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   PANTHER; PTHR19410:SF12; Enoyl-ACP_rdct; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
PE   3: Inferred from homology;
KW   Complete proteome; Fatty acid biosynthesis; Lipid synthesis; NAD;
KW   Oxidoreductase.
FT   CHAIN         1    258       Enoyl-[acyl-carrier-protein] reductase
FT                                [NADH].
FT                                /FTId=PRO_0000054893.
FT   NP_BIND      10     36       NAD (By similarity).
FT   ACT_SITE    158    158       Proton acceptor (By similarity).
SQ   SEQUENCE   258 AA;  27421 MW;  45012CA8497E001B CRC64;
     MLNLTGKNAL VTGIANNRSI AWGIAQQLHA AGANLGITYL PDERGKFEKK VSELVEPLNP
     SLFLPCNVQN DEQIQSTFDT IRDKWGRLDI LIHCLAFANR DDLTGDFSQT SRAGFATALD
     ISTFSLVQLS GAAKPLMTEG GSIITLSYLG GVRAVPNYNV MGVAKAGLEA SVRYLASELG
     SQNIRVNAIS AGPIRTLASS AVGGILDMIH HVEQVAPLRR TVTQLEVGNT AAFLASDLAS
     GITGQVLYVD AGYEIMGM
//