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Q05069

- FABI_NOSS1

UniProt

Q05069 - FABI_NOSS1

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Protein

Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Gene

fabI

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism By similarity.By similarity

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131NAD; via carbonyl oxygenBy similarity
Binding sitei95 – 951NAD; via carbonyl oxygenBy similarity
Binding sitei98 – 981Substrate; via amide nitrogen and carbonyl oxygenBy similarity
Active sitei148 – 1481Proton acceptorBy similarity
Active sitei158 – 1581Proton acceptorBy similarity
Binding sitei165 – 1651NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 202NADBy similarity
Nucleotide bindingi67 – 682NADBy similarity
Nucleotide bindingi194 – 1985NADBy similarity

GO - Molecular functioni

  1. enoyl-[acyl-carrier-protein] reductase (NADH) activity Source: UniProtKB

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
  2. protein homotetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI (EC:1.3.1.9)
Short name:
ENR
Alternative name(s):
NADH-dependent enoyl-ACP reductase
Gene namesi
Name:fabI
Ordered Locus Names:all4391
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Enoyl-[acyl-carrier-protein] reductase [NADH] FabIPRO_0000054893Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi103690.all4391.

Structurei

3D structure databases

ProteinModelPortaliQ05069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0623.
KOiK00208.
OMAiIAKRCAP.
OrthoDBiEOG6HF644.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PIRSFiPIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSiPR00081. GDHRDH.

Sequencei

Sequence statusi: Complete.

Q05069-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNLTGKNAL VTGIANNRSI AWGIAQQLHA AGANLGITYL PDERGKFEKK
60 70 80 90 100
VSELVEPLNP SLFLPCNVQN DEQIQSTFDT IRDKWGRLDI LIHCLAFANR
110 120 130 140 150
DDLTGDFSQT SRAGFATALD ISTFSLVQLS GAAKPLMTEG GSIITLSYLG
160 170 180 190 200
GVRAVPNYNV MGVAKAGLEA SVRYLASELG SQNIRVNAIS AGPIRTLASS
210 220 230 240 250
AVGGILDMIH HVEQVAPLRR TVTQLEVGNT AAFLASDLAS GITGQVLYVD

AGYEIMGM
Length:258
Mass (Da):27,421
Last modified:May 30, 2000 - v2
Checksum:i45012CA8497E001B
GO

Sequence cautioni

The sequence AAD04184.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAB76090.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10036 Genomic DNA. Translation: AAD04184.1. Different initiation.
BA000019 Genomic DNA. Translation: BAB76090.1. Different initiation.
PIRiAG2354.
RefSeqiNP_488431.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76090; BAB76090; BAB76090.
GeneIDi1107992.
KEGGiana:all4391.
PATRICi22779366. VBINosSp37423_5130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L10036 Genomic DNA. Translation: AAD04184.1 . Different initiation.
BA000019 Genomic DNA. Translation: BAB76090.1 . Different initiation.
PIRi AG2354.
RefSeqi NP_488431.1. NC_003272.1.

3D structure databases

ProteinModelPortali Q05069.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all4391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB76090 ; BAB76090 ; BAB76090 .
GeneIDi 1107992.
KEGGi ana:all4391.
PATRICi 22779366. VBINosSp37423_5130.

Phylogenomic databases

eggNOGi COG0623.
KOi K00208.
OMAi IAKRCAP.
OrthoDBi EOG6HF644.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR014358. Enoyl-ACP_Rdtase_NADH.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PIRSFi PIRSF000094. Enoyl-ACP_rdct. 1 hit.
PRINTSi PR00081. GDHRDH.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Anabaena sp. strain PCC 7120 bifA gene encoding a sequence-specific DNA-binding protein cloned by in vivo transcriptional interference selection."
    Wei T.-F., Ramasubramanian T.S., Pu F., Golden J.W.
    J. Bacteriol. 175:4025-4035(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiFABI_NOSS1
AccessioniPrimary (citable) accession number: Q05069
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 30, 2000
Last modified: October 1, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3