Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sex-determining region Y protein

Gene

SRY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.By similarity4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi60 – 12869HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA binding, bending Source: Ensembl
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Differentiation, Sexual differentiation, Transcription, Transcription regulation

Keywords - Ligandi

Calmodulin-binding, DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-3769402. Deactivation of the beta-catenin transactivating complex.
SignaLinkiQ05066.
SIGNORiQ05066.

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y protein
Alternative name(s):
Testis-determining factor
Gene namesi
Name:SRY
Synonyms:TDF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:11311. SRY.

Subcellular locationi

  • Nucleus speckle
  • Cytoplasm

  • Note: Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus. Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nuclear speck Source: UniProtKB-SubCell
  • nuclear transcription factor complex Source: Ensembl
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

46,XY sex reversal 1 (SRXY1)24 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients manifest rapid and early degeneration of their gonads, which are present in the adult as 'streak gonads', consisting mainly of fibrous tissue and variable amounts of ovarian stroma. As a result these patients do not develop secondary sexual characteristics at puberty. The external genitalia in these subjects are completely female, and Muellerian structures are normal.
See also OMIM:400044
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31S → L in SRXY1. 1 Publication
VAR_030019
Natural varianti18 – 181S → N in SRXY1; partial; also in two patients with a Turner syndrome phenotype. 2 Publications
Corresponds to variant rs104894971 [ dbSNP | Ensembl ].
VAR_003717
Natural varianti60 – 601V → A in SRXY1. 1 Publication
Corresponds to variant rs764249635 [ dbSNP | Ensembl ].
VAR_003718
Natural varianti60 – 601V → L in SRXY1. 2 Publications
Corresponds to variant rs104894957 [ dbSNP | Ensembl ].
VAR_003719
Natural varianti62 – 621R → G in SRXY1. 1 Publication
VAR_003720
Natural varianti64 – 641M → I in SRXY1; alters interaction with DNA and DNA bending. 2 Publications
Corresponds to variant rs104894969 [ dbSNP | Ensembl ].
VAR_003721
Natural varianti64 – 641M → R in SRXY1. 1 Publication
VAR_017298
Natural varianti67 – 671F → V in SRXY1. 1 Publication
VAR_017299
Natural varianti68 – 681I → T in SRXY1. 1 Publication
Corresponds to variant rs104894968 [ dbSNP | Ensembl ].
VAR_003722
Natural varianti76 – 761R → S in SRXY1. 1 Publication
VAR_017300
Natural varianti78 – 781M → T in SRXY1. 1 Publication
VAR_003723
Natural varianti87 – 871N → Y in SRXY1. 1 Publication
VAR_017301
Natural varianti90 – 901I → M in SRXY1. 3 Publications
Corresponds to variant rs104894959 [ dbSNP | Ensembl ].
VAR_003724
Natural varianti91 – 911S → G in SRXY1. 1 Publication
VAR_003725
Natural varianti95 – 951G → E in SRXY1. 1 Publication
Corresponds to variant rs104894972 [ dbSNP | Ensembl ].
VAR_017302
Natural varianti95 – 951G → R in SRXY1. 1 Publication
Corresponds to variant rs104894974 [ dbSNP | Ensembl ].
VAR_003726
Natural varianti101 – 1011L → H in SRXY1. 1 Publication
VAR_003727
Natural varianti106 – 1061K → I in SRXY1. 1 Publication
Corresponds to variant rs104894964 [ dbSNP | Ensembl ].
VAR_003728
Natural varianti108 – 1081P → R in SRXY1. 1 Publication
VAR_003729
Natural varianti109 – 1091F → S in SRXY1. 1 Publication
Corresponds to variant rs104894956 [ dbSNP | Ensembl ].
VAR_003730
Natural varianti113 – 1131A → T in SRXY1. 1 Publication
Corresponds to variant rs104894966 [ dbSNP | Ensembl ].
VAR_003731
Natural varianti125 – 1251P → L in SRXY1. 1 Publication
VAR_003732
Natural varianti127 – 1271Y → C in SRXY1. 1 Publication
VAR_003733
Natural varianti127 – 1271Y → F in SRXY1. 1 Publication
Corresponds to variant rs104894973 [ dbSNP | Ensembl ].
VAR_017303
Natural varianti131 – 1311P → R in SRXY1. 1 Publication
VAR_017304
Natural varianti133 – 1331R → W in SRXY1. 1 Publication
Corresponds to variant rs104894976 [ dbSNP | Ensembl ].
VAR_003734

A 45,X chromosomal aberration involving SRY is found in Turner syndrome, a disease characterized by gonadal dysgenesis with short stature, "streak gonads", variable abnormalities such as webbing of the neck, cubitus valgus, cardiac defects, low posterior hair line. The phenotype is female.

46,XX sex reversal 1 (SRXX1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition in which male gonads develop in a genetic female (female to male sex reversal).
See also OMIM:400045

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi31 – 333SSS → AAA: Abolishes its phosphorylation by PKA. Does not enhance its DNA-binding activity. Abolishes stimulation of transcription repression. 1 Publication
Mutagenesisi62 – 621R → G: Strongly reduces nuclear localization. Strongly reduces nuclear localization; when associated with W-133. Reduces interaction with KPNB1. Abolishes DNA-binding. 1 Publication
Mutagenesisi64 – 641M → I: Abolishes nuclear localization. 1 Publication
Mutagenesisi75 – 751R → N: Strongly reduces nuclear localization. Abolishes DNA-binding. Does not reduce interaction with KPNB1 and CAML. 2 Publications
Mutagenesisi76 – 761R → P: Reduces nuclear localization. Reduces DNA-binding. Does not reduce interaction with KPNB1 and CAML. 2 Publications
Mutagenesisi115 – 1151K → R: Does not abolish acetylation activity. 1 Publication
Mutagenesisi123 – 1231K → R: Does not abolish acetylation. 1 Publication
Mutagenesisi128 – 1281K → R: Does not abolish acetylation. 1 Publication
Mutagenesisi133 – 1331R → W: Reduces nuclear localization. Strongly reduces nuclear localization; when associated with G-62. Reduces interaction with KPNB1. Does not reduce interaction with CAML. Does not abolish DNA-binding. 2 Publications
Mutagenesisi134 – 1341K → R: Does not abolish acetylation. 1 Publication
Mutagenesisi136 – 1361K → R: Abolishes acetylation. Does not abolish interaction with EP300. Does not abolish DNA-binding. Enhances cytoplasmic localization. Abolishes interaction with KPNB1. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MalaCardsiSRY.
MIMi400044. phenotype.
400045. phenotype.
Orphaneti1772. 45,X/46,XY mixed gonadal dysgenesis.
2138. 46,XX ovotesticular disorder of sex development.
393. 46,XX testicular disorder of sex development.
242. 46,XY complete gonadal dysgenesis.
251510. 46,XY partial gonadal dysgenesis.
PharmGKBiPA36135.

Polymorphism and mutation databases

DMDMi548983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Sex-determining region Y proteinPRO_0000048671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei136 – 1361N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylated on serine residues by PKA. Phosphorylation by PKA enhances its DNA-binding activity and stimulates transcription repression.1 Publication
Acetylation of Lys-136 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3.1 Publication
Poly-ADP-ribosylated by PARP1. ADP-ribosylation reduces its DNA-binding activity.

Keywords - PTMi

Acetylation, ADP-ribosylation

Proteomic databases

PaxDbiQ05066.
PRIDEiQ05066.

PTM databases

iPTMnetiQ05066.
PhosphoSiteiQ05066.

Expressioni

Gene expression databases

BgeeiENSG00000184895.
CleanExiHS_SRY.
ExpressionAtlasiQ05066. baseline and differential.
GenevisibleiQ05066. HS.

Interactioni

Subunit structurei

Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its DNA-binding activity. The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form (By similarity). Interaction with PARP1 impaired its DNA-binding activity (By similarity).By similarity

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112614. 19 interactions.
IntActiQ05066. 1 interaction.
MINTiMINT-1367278.
STRINGi9606.ENSP00000372547.

Structurei

Secondary structure

1
204
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi66 – 8116Combined sources
Beta strandi86 – 883Combined sources
Helixi89 – 9911Combined sources
Helixi103 – 12321Combined sources
Beta strandi124 – 1263Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HRYNMR-A56-131[»]
1HRZNMR-A56-131[»]
1J46NMR-A57-140[»]
1J47NMR-A57-140[»]
2GZKNMR-A56-130[»]
ProteinModelPortaliQ05066.
SMRiQ05066. Positions 58-130.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ05066.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 13678Sufficient for interaction with KPNB1Add
BLAST
Regioni61 – 7717Required for nuclear localizationAdd
BLAST
Regioni107 – 13933Sufficient for interaction with EP300Add
BLAST
Regioni130 – 1367Required for nuclear localization
Regioni138 – 15518Necessary for interaction with ZNF208 isoform KRAB-OAdd
BLAST
Regioni198 – 2047Necessary for interaction with SLC9A3R2

Domaini

DNA binding and bending properties of the HMG domains of human and mouse SRY differ form each other. Human SRY shows more extensive minor groove contacts with DNA and a lower specificity of sequence recognition than mouse SRY.

Sequence similaritiesi

Belongs to the SRY family.Curated
Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000008601.
HOVERGENiHBG008712.
InParanoidiQ05066.
KOiK09266.
OMAiVWSRDQR.
OrthoDBiEOG091G0JDD.
PhylomeDBiQ05066.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05066-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSYASAMLS VFNSDDYSPA VQENIPALRR SSSFLCTESC NSKYQCETGE
60 70 80 90 100
NSKGNVQDRV KRPMNAFIVW SRDQRRKMAL ENPRMRNSEI SKQLGYQWKM
110 120 130 140 150
LTEAEKWPFF QEAQKLQAMH REKYPNYKYR PRRKAKMLPK NCSLLPADPA
160 170 180 190 200
SVLCSEVQLD NRLYRDDCTK ATHSRMEHQL GHLPPINAAS SPQQRDRYSH

WTKL
Length:204
Mass (Da):23,884
Last modified:June 1, 1994 - v1
Checksum:i84323C30A9C2173E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31S → L in SRXY1. 1 Publication
VAR_030019
Natural varianti18 – 181S → N in SRXY1; partial; also in two patients with a Turner syndrome phenotype. 2 Publications
Corresponds to variant rs104894971 [ dbSNP | Ensembl ].
VAR_003717
Natural varianti60 – 601V → A in SRXY1. 1 Publication
Corresponds to variant rs764249635 [ dbSNP | Ensembl ].
VAR_003718
Natural varianti60 – 601V → L in SRXY1. 2 Publications
Corresponds to variant rs104894957 [ dbSNP | Ensembl ].
VAR_003719
Natural varianti62 – 621R → G in SRXY1. 1 Publication
VAR_003720
Natural varianti64 – 641M → I in SRXY1; alters interaction with DNA and DNA bending. 2 Publications
Corresponds to variant rs104894969 [ dbSNP | Ensembl ].
VAR_003721
Natural varianti64 – 641M → R in SRXY1. 1 Publication
VAR_017298
Natural varianti67 – 671F → V in SRXY1. 1 Publication
VAR_017299
Natural varianti68 – 681I → T in SRXY1. 1 Publication
Corresponds to variant rs104894968 [ dbSNP | Ensembl ].
VAR_003722
Natural varianti76 – 761R → S in SRXY1. 1 Publication
VAR_017300
Natural varianti78 – 781M → T in SRXY1. 1 Publication
VAR_003723
Natural varianti87 – 871N → Y in SRXY1. 1 Publication
VAR_017301
Natural varianti90 – 901I → M in SRXY1. 3 Publications
Corresponds to variant rs104894959 [ dbSNP | Ensembl ].
VAR_003724
Natural varianti91 – 911S → G in SRXY1. 1 Publication
VAR_003725
Natural varianti95 – 951G → E in SRXY1. 1 Publication
Corresponds to variant rs104894972 [ dbSNP | Ensembl ].
VAR_017302
Natural varianti95 – 951G → R in SRXY1. 1 Publication
Corresponds to variant rs104894974 [ dbSNP | Ensembl ].
VAR_003726
Natural varianti101 – 1011L → H in SRXY1. 1 Publication
VAR_003727
Natural varianti106 – 1061K → I in SRXY1. 1 Publication
Corresponds to variant rs104894964 [ dbSNP | Ensembl ].
VAR_003728
Natural varianti108 – 1081P → R in SRXY1. 1 Publication
VAR_003729
Natural varianti109 – 1091F → S in SRXY1. 1 Publication
Corresponds to variant rs104894956 [ dbSNP | Ensembl ].
VAR_003730
Natural varianti113 – 1131A → T in SRXY1. 1 Publication
Corresponds to variant rs104894966 [ dbSNP | Ensembl ].
VAR_003731
Natural varianti125 – 1251P → L in SRXY1. 1 Publication
VAR_003732
Natural varianti127 – 1271Y → C in SRXY1. 1 Publication
VAR_003733
Natural varianti127 – 1271Y → F in SRXY1. 1 Publication
Corresponds to variant rs104894973 [ dbSNP | Ensembl ].
VAR_017303
Natural varianti131 – 1311P → R in SRXY1. 1 Publication
VAR_017304
Natural varianti133 – 1331R → W in SRXY1. 1 Publication
Corresponds to variant rs104894976 [ dbSNP | Ensembl ].
VAR_003734

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53772 Genomic DNA. Translation: CAA37790.1.
L10101 mRNA. Translation: AAA60590.1.
L10102 Genomic DNA. Translation: AAA60591.1.
L08063 Genomic DNA. Translation: AAA16878.1.
X96421 Genomic DNA. Translation: CAA65281.1.
S53156 mRNA. Translation: AAB25008.1.
S56543 mRNA. Translation: AAB25716.1.
BC074923 mRNA. Translation: AAH74923.1.
BC074924 mRNA. Translation: AAH74924.1.
CCDSiCCDS14772.1.
PIRiA47533.
RefSeqiNP_003131.1. NM_003140.2.
UniGeneiHs.1992.

Genome annotation databases

EnsembliENST00000383070; ENSP00000372547; ENSG00000184895.
GeneIDi6736.
KEGGihsa:6736.
UCSCiuc004fqg.3. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Protein Spotlight

The tenuous nature of sex - Issue 80 of March 2007

Wikipedia

SRY entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53772 Genomic DNA. Translation: CAA37790.1.
L10101 mRNA. Translation: AAA60590.1.
L10102 Genomic DNA. Translation: AAA60591.1.
L08063 Genomic DNA. Translation: AAA16878.1.
X96421 Genomic DNA. Translation: CAA65281.1.
S53156 mRNA. Translation: AAB25008.1.
S56543 mRNA. Translation: AAB25716.1.
BC074923 mRNA. Translation: AAH74923.1.
BC074924 mRNA. Translation: AAH74924.1.
CCDSiCCDS14772.1.
PIRiA47533.
RefSeqiNP_003131.1. NM_003140.2.
UniGeneiHs.1992.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HRYNMR-A56-131[»]
1HRZNMR-A56-131[»]
1J46NMR-A57-140[»]
1J47NMR-A57-140[»]
2GZKNMR-A56-130[»]
ProteinModelPortaliQ05066.
SMRiQ05066. Positions 58-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112614. 19 interactions.
IntActiQ05066. 1 interaction.
MINTiMINT-1367278.
STRINGi9606.ENSP00000372547.

PTM databases

iPTMnetiQ05066.
PhosphoSiteiQ05066.

Polymorphism and mutation databases

DMDMi548983.

Proteomic databases

PaxDbiQ05066.
PRIDEiQ05066.

Protocols and materials databases

DNASUi6736.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383070; ENSP00000372547; ENSG00000184895.
GeneIDi6736.
KEGGihsa:6736.
UCSCiuc004fqg.3. human.

Organism-specific databases

CTDi6736.
GeneCardsiSRY.
GeneReviewsiSRY.
HGNCiHGNC:11311. SRY.
MalaCardsiSRY.
MIMi400044. phenotype.
400045. phenotype.
480000. gene.
neXtProtiNX_Q05066.
Orphaneti1772. 45,X/46,XY mixed gonadal dysgenesis.
2138. 46,XX ovotesticular disorder of sex development.
393. 46,XX testicular disorder of sex development.
242. 46,XY complete gonadal dysgenesis.
251510. 46,XY partial gonadal dysgenesis.
PharmGKBiPA36135.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0527. Eukaryota.
ENOG410XT0K. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000008601.
HOVERGENiHBG008712.
InParanoidiQ05066.
KOiK09266.
OMAiVWSRDQR.
OrthoDBiEOG091G0JDD.
PhylomeDBiQ05066.

Enzyme and pathway databases

ReactomeiR-HSA-3769402. Deactivation of the beta-catenin transactivating complex.
SignaLinkiQ05066.
SIGNORiQ05066.

Miscellaneous databases

EvolutionaryTraceiQ05066.
GeneWikiiSRY.
GenomeRNAii6736.
PROiQ05066.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184895.
CleanExiHS_SRY.
ExpressionAtlasiQ05066. baseline and differential.
GenevisibleiQ05066. HS.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR017253. SRY.
[Graphical view]
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 1 hit.
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
PIRSFiPIRSF037653. SRY. 1 hit.
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRY_HUMAN
AccessioniPrimary (citable) accession number: Q05066
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 7, 2016
This is version 176 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.