ID   MUTA_STRCM              Reviewed;         616 AA.
AC   Q05064;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   16-JUN-2009, entry version 51.
DE   RecName: Full=Methylmalonyl-CoA mutase small subunit;
DE            EC=5.4.99.2;
DE   AltName: Full=MCM-beta;
GN   Name=mutA;
OS   Streptomyces cinnamonensis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Streptomycineae; Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A3823.5;
RX   MEDLINE=93273720; PubMed=8099072;
RA   Birch A., Leiser A., Robinson J.A.;
RT   "Cloning, sequencing, and expression of the gene encoding
RT   methylmalonyl-coenzyme A mutase from Streptomyces cinnamonensis.";
RL   J. Bacteriol. 175:3511-3519(1993).
CC   -!- FUNCTION: Catalyzes the isomerization of succinyl-CoA to
CC       methylmalonyl-CoA during synthesis of propionate from
CC       tricarboxylic acid-cycle intermediates. This conversion most
CC       likely represents an important source of building blocks for
CC       polyketide antibiotic biosynthesis. It is unable to catalyze the
CC       conversion of isobutyryl-CoA into N-butyryl-CoA.
CC   -!- CATALYTIC ACTIVITY: (R)-methylmalonyl-CoA = succinyl-CoA.
CC   -!- COFACTOR: Adenosylcobalamin.
CC   -!- PATHWAY: Metabolic intermediate metabolism; propionyl-CoA
CC       degradation; succinyl-CoA from propionyl-CoA: step 3/3.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
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DR   EMBL; L10064; AAA03040.1; -; Unassigned_DNA.
DR   PIR; A40595; A40595.
DR   HSSP; P11652; 2REQ.
DR   BRENDA; 5.4.99.2; 1647.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0050897; F:cobalt ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:EC.
DR   GO; GO:0019652; P:lactate fermentation to propionate and acetate; IEA:InterPro.
DR   InterPro; IPR014348; Cbl-dep_enz_cat-sub.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR006099; MMCoA_mutase_a/b_cat.
DR   InterPro; IPR004608; MMCoA_mutase_b.
DR   Gene3D; G3DSA:3.40.50.280; B12_bd; 1.
DR   Gene3D; G3DSA:3.20.20.240; Cobalamin-dep_enz_cat; 1.
DR   Pfam; PF01642; MM_CoA_mutase; 1.
DR   TIGRFAMs; TIGR00642; mmCoA_mut_beta; 1.
DR   PROSITE; PS00544; METMALONYL_COA_MUTASE; 1.
PE   3: Inferred from homology;
KW   Cobalamin; Cobalt; Isomerase.
FT   CHAIN         1    616       Methylmalonyl-CoA mutase small subunit.
FT                                /FTId=PRO_0000194269.
SQ   SEQUENCE   616 AA;  65041 MW;  09CA24006E169AE6 CRC64;
     MTVLPDDGLS LAAEFPDATH EQWHRLVEGV VRKSGKDVSG TAAEEALSTT LEDGLTTRPL
     YTARDAAPDA GFPGFAPFVR GSVPEGNTPG GWDVRQRYAS ADPARTNEAV LTDLENGVTS
     LWLTLGSAGL PVTGLERALD GVYLDLVPVA LDAGSEAATA ARELLRLYEA AGVADDAVRG
     TLGADPLGHE ARTGEKSTSF AAVAELARLC GERYPGLRAL TVDALPYHEA GASAAQELGA
     SLATGVEYLR ALHDKGLGVE KAFAQLEFRF AATADQFLTI AKLRAARRLW ARVAEVSGVP
     AAGAQRQHAV TSPVMMTRRD PWVNMLRTTV ACLGAGVGGA DAVTVLPFDH ELGLPDAFAR
     RIARNTSTIL LEESHLARVI DPAGGSWYVE RLTDELAHAA WDFFKEIERA DGQVAALRSG
     LVGDRIAATW AERRKKLARR REPITGVSEF PLLTERPVER EPAPAAPPGG LPRVRRDEAY
     EELRGRSDAH LEATGARPKV FIAALGPAAA HTARATFAAN LFMAGGVEPV HDPVSVDAET
     AAEAFAASGA TVACLCSSDV LYAEQAEAVA RALKSAGALR VFLAGRGEFA DIDEYVFAGC
     DAVAVLTSTL DRMGVA
//