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Protein

Methylmalonyl-CoA mutase small subunit

Gene

mutA

Organism
Streptomyces cinnamonensis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthesis. It is unable to catalyze the conversion of isobutyryl-CoA into N-butyryl-CoA.

Catalytic activityi

(R)-methylmalonyl-CoA = succinyl-CoA.

Cofactori

Pathwayi: propanoyl-CoA degradation

This protein is involved in step 3 of the subpathway that synthesizes succinyl-CoA from propanoyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Methylmalonyl-CoA mutase large subunit (mutB), Methylmalonyl-CoA mutase small subunit (mutA)
This subpathway is part of the pathway propanoyl-CoA degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinyl-CoA from propanoyl-CoA, the pathway propanoyl-CoA degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

UniPathwayiUPA00945; UER00910.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylmalonyl-CoA mutase small subunit (EC:5.4.99.2)
Alternative name(s):
MCM-beta
Gene namesi
Name:mutA
OrganismiStreptomyces cinnamonensis
Taxonomic identifieri1900 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616Methylmalonyl-CoA mutase small subunitPRO_0000194269Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliQ05064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methylmalonyl-CoA mutase family.Curated

Family and domain databases

Gene3Di1.10.196.20. 1 hit.
3.20.20.240. 1 hit.
3.40.50.280. 1 hit.
InterProiIPR016176. Cbl-dep_enz_cat.
IPR014348. Cbl-dep_enz_cat-sub.
IPR006158. Cobalamin-bd.
IPR024067. Me-malonyl-CoA_mutase_sm_su_N.
IPR006099. MeMalonylCoA_mutase_a/b_cat.
IPR004608. MMCoA_mutase_b.
[Graphical view]
PfamiPF01642. MM_CoA_mutase. 1 hit.
[Graphical view]
SUPFAMiSSF51703. SSF51703. 1 hit.
TIGRFAMsiTIGR00642. mmCoA_mut_beta. 1 hit.
PROSITEiPS00544. METMALONYL_COA_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVLPDDGLS LAAEFPDATH EQWHRLVEGV VRKSGKDVSG TAAEEALSTT
60 70 80 90 100
LEDGLTTRPL YTARDAAPDA GFPGFAPFVR GSVPEGNTPG GWDVRQRYAS
110 120 130 140 150
ADPARTNEAV LTDLENGVTS LWLTLGSAGL PVTGLERALD GVYLDLVPVA
160 170 180 190 200
LDAGSEAATA ARELLRLYEA AGVADDAVRG TLGADPLGHE ARTGEKSTSF
210 220 230 240 250
AAVAELARLC GERYPGLRAL TVDALPYHEA GASAAQELGA SLATGVEYLR
260 270 280 290 300
ALHDKGLGVE KAFAQLEFRF AATADQFLTI AKLRAARRLW ARVAEVSGVP
310 320 330 340 350
AAGAQRQHAV TSPVMMTRRD PWVNMLRTTV ACLGAGVGGA DAVTVLPFDH
360 370 380 390 400
ELGLPDAFAR RIARNTSTIL LEESHLARVI DPAGGSWYVE RLTDELAHAA
410 420 430 440 450
WDFFKEIERA DGQVAALRSG LVGDRIAATW AERRKKLARR REPITGVSEF
460 470 480 490 500
PLLTERPVER EPAPAAPPGG LPRVRRDEAY EELRGRSDAH LEATGARPKV
510 520 530 540 550
FIAALGPAAA HTARATFAAN LFMAGGVEPV HDPVSVDAET AAEAFAASGA
560 570 580 590 600
TVACLCSSDV LYAEQAEAVA RALKSAGALR VFLAGRGEFA DIDEYVFAGC
610
DAVAVLTSTL DRMGVA
Length:616
Mass (Da):65,041
Last modified:February 1, 1994 - v1
Checksum:i09CA24006E169AE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10064 Unassigned DNA. Translation: AAA03040.1.
PIRiA40595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10064 Unassigned DNA. Translation: AAA03040.1.
PIRiA40595.

3D structure databases

ProteinModelPortaliQ05064.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00945; UER00910.

Family and domain databases

Gene3Di1.10.196.20. 1 hit.
3.20.20.240. 1 hit.
3.40.50.280. 1 hit.
InterProiIPR016176. Cbl-dep_enz_cat.
IPR014348. Cbl-dep_enz_cat-sub.
IPR006158. Cobalamin-bd.
IPR024067. Me-malonyl-CoA_mutase_sm_su_N.
IPR006099. MeMalonylCoA_mutase_a/b_cat.
IPR004608. MMCoA_mutase_b.
[Graphical view]
PfamiPF01642. MM_CoA_mutase. 1 hit.
[Graphical view]
SUPFAMiSSF51703. SSF51703. 1 hit.
TIGRFAMsiTIGR00642. mmCoA_mut_beta. 1 hit.
PROSITEiPS00544. METMALONYL_COA_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUTA_STRCM
AccessioniPrimary (citable) accession number: Q05064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 24, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.