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Protein

Chaperonin CPN60-1, mitochondrial

Gene

CPN60-1

Organism
Cucurbita maxima (Pumpkin) (Winter squash)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperonin CPN60-1, mitochondrial
Alternative name(s):
HSP60-1
Gene namesi
Name:CPN60-1
OrganismiCucurbita maxima (Pumpkin) (Winter squash)
Taxonomic identifieri3661 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeCucurbiteaeCucurbita

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32MitochondrionAdd BLAST32
ChainiPRO_000000501133 – 575Chaperonin CPN60-1, mitochondrialAdd BLAST543

Proteomic databases

PRIDEiQ05045

Expressioni

Inductioni

By heat shock.

Structurei

3D structure databases

ProteinModelPortaliQ05045
SMRiQ05045
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05045-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRFATGLAS KARLARNGAN QIASRSNWRR NYAAKDVKFG VEARGLMLKG
60 70 80 90 100
VEDLADAVKV TMGPKGRTVV IEQSFGAPKV TKDGVTVAKS IEFKDKVKNV
110 120 130 140 150
GASLVKQVAN ATNDVAGDGT TCATILTKAI FTEGCKSVAS GMNAMDLRRG
160 170 180 190 200
ISMAVDSVVT NLKSRARMIS TSEEIAQVGT ISANGEREIG ELIAKAMEKV
210 220 230 240 250
GKEGVITISD GKTMDNELEV VEGMKLDRGY ISPYFITNQK NQKCELDDPL
260 270 280 290 300
IIIYEKKISS INAVVKVLEL ALKKQRPLLI VSEDVESEAL ATLILNKLRA
310 320 330 340 350
GIKVCAIKAP GFGENRKAGL QDLAVLTGGQ VITEELGMNL EKVDLDMLGS
360 370 380 390 400
CKKITISKDD TVILDGAGDK KAIEERCDQI RSGIEASTSD YDKEKLQERL
410 420 430 440 450
AKLSGGVAVL KIGGASEAEV GEKKDRVTDA LNATKAAVEE GIVPGGGVAL
460 470 480 490 500
LYASKELDKL PTANFDQKIG VQIIQNALKT PVHTIASNAG VEGAVVVGKL
510 520 530 540 550
LEQDDPDLGY DAAKGEYVDM VKAGIIDPLK VIRTALVDAA SVSSLMTTTE
560 570
VVVVELPKDE NEVPAMGGGM GGMDY
Length:575
Mass (Da):61,055
Last modified:February 1, 1994 - v1
Checksum:iD4646FE516B1DFBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70867 mRNA Translation: CAA50217.1

Similar proteinsi

Entry informationi

Entry nameiCH61_CUCMA
AccessioniPrimary (citable) accession number: Q05045
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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