Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Platelet-derived growth factor subunit B

Gene

Pdgfb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei100Involved in receptor binding1
Sitei103Involved in receptor binding1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor subunit B
Short name:
PDGF subunit B
Alternative name(s):
PDGF-2
Platelet-derived growth factor B chain
Platelet-derived growth factor beta polypeptide
Gene namesi
Name:Pdgfb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3283 Pdgfb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 12By similarityAdd BLAST›12
PropeptideiPRO_000002337713 – 73Removed in mature formBy similarityAdd BLAST61
ChainiPRO_000002337874 – 182Platelet-derived growth factor subunit BAdd BLAST109
PropeptideiPRO_0000023379183 – 225Removed in mature formBy similarityAdd BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 133By similarity
Disulfide bondi116InterchainBy similarity
Disulfide bondi122 ↔ 170By similarity
Disulfide bondi125InterchainBy similarity
Disulfide bondi126 ↔ 172By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ05028
PRIDEiQ05028

PTM databases

PhosphoSitePlusiQ05028

Expressioni

Tissue specificityi

Expressed in a distinct subpopulation of smooth muscle cells in injured arteries.

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023196

Structurei

3D structure databases

ProteinModelPortaliQ05028
SMRiQ05028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ45 Eukaryota
ENOG410XWTB LUCA
HOGENOMiHOG000286027
HOVERGENiHBG053546
InParanoidiQ05028
KOiK17386
PhylomeDBiQ05028

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR006782 PDGF_N
IPR015583 PDGF_suB
PANTHERiPTHR11633:SF2 PTHR11633:SF2, 1 hit
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF04692 PDGF_N, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LPLCCYLRLV SAEGDPIPEE LYEMLSDHSI RSFDDLQRLL HRDSVDEDGA
60 70 80 90 100
ELDLNMTRAH SGVESESSSR GRRSLGSLAA AEPAVIAECK TRTEVFQISR
110 120 130 140 150
NLIDRTNANF LVWPPCVEVQ RCSGCCNNRN VQCRASQVQM RPVQVRKIEI
160 170 180 190 200
VRKKPVFKKA TVTLEDHLAC KCETVVTPRP VTRSPGTSRE HRAKTPQTRV
210 220
TVRTVRIRRP PKGKHRKFKH THDKK
Length:225
Mass (Da):25,603
Last modified:February 1, 1994 - v1
Checksum:i0DAE138B0AA70F0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2251

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14117 mRNA Translation: CAA78487.1
L40991 mRNA Translation: AAA70048.1
PIRiS25097
RefSeqiNP_113712.1, NM_031524.1
UniGeneiRn.198230

Genome annotation databases

GeneIDi24628
KEGGirno:24628
UCSCiRGD:3283 rat

Similar proteinsi

Entry informationi

Entry nameiPDGFB_RAT
AccessioniPrimary (citable) accession number: Q05028
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health