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Protein

Platelet-derived growth factor subunit B

Gene

Pdgfb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei100 – 1001Involved in receptor binding
Sitei103 – 1031Involved in receptor binding

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor subunit B
Short name:
PDGF subunit B
Alternative name(s):
PDGF-2
Platelet-derived growth factor B chain
Platelet-derived growth factor beta polypeptide
Gene namesi
Name:Pdgfb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3283. Pdgfb.

Subcellular locationi

  • Secreted By similarity

  • Note: Released by platelets upon wounding.By similarity

GO - Cellular componenti

  • basolateral plasma membrane Source: UniProtKB
  • cell surface Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • dendrite Source: RGD
  • extracellular space Source: RGD
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 12›12By similarityAdd
BLAST
Propeptidei13 – 7361Removed in mature formBy similarityPRO_0000023377Add
BLAST
Chaini74 – 182109Platelet-derived growth factor subunit BPRO_0000023378Add
BLAST
Propeptidei183 – 22543Removed in mature formBy similarityPRO_0000023379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Disulfide bondi89 ↔ 133By similarity
Disulfide bondi116 – 116InterchainBy similarity
Disulfide bondi122 ↔ 170By similarity
Disulfide bondi125 – 125InterchainBy similarity
Disulfide bondi126 ↔ 172By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ05028.
PRIDEiQ05028.

PTM databases

PhosphoSiteiQ05028.

Expressioni

Tissue specificityi

Expressed in a distinct subpopulation of smooth muscle cells in injured arteries.

Interactioni

Subunit structurei

Homodimer; antiparallel disulfide-linked dimer. Heterodimer with PDGFA; antiparallel disulfide-linked dimer. The PDGFB homodimer interacts with PDGFRA and PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. The heterodimer composed of PDGFA and PDGFB interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB. Interacts with XLKD1 (By similarity).By similarity

GO - Molecular functioni

  • growth factor activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023196.

Structurei

3D structure databases

ProteinModelPortaliQ05028.
SMRiQ05028. Positions 81-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJ45. Eukaryota.
ENOG410XWTB. LUCA.
HOGENOMiHOG000286027.
HOVERGENiHBG053546.
InParanoidiQ05028.
KOiK17386.
PhylomeDBiQ05028.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR006782. PDGF_N.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF04692. PDGF_N. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05028-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LPLCCYLRLV SAEGDPIPEE LYEMLSDHSI RSFDDLQRLL HRDSVDEDGA
60 70 80 90 100
ELDLNMTRAH SGVESESSSR GRRSLGSLAA AEPAVIAECK TRTEVFQISR
110 120 130 140 150
NLIDRTNANF LVWPPCVEVQ RCSGCCNNRN VQCRASQVQM RPVQVRKIEI
160 170 180 190 200
VRKKPVFKKA TVTLEDHLAC KCETVVTPRP VTRSPGTSRE HRAKTPQTRV
210 220
TVRTVRIRRP PKGKHRKFKH THDKK
Length:225
Mass (Da):25,603
Last modified:February 1, 1994 - v1
Checksum:i0DAE138B0AA70F0F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei225 – 2251

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14117 mRNA. Translation: CAA78487.1.
L40991 mRNA. Translation: AAA70048.1.
PIRiS25097.
RefSeqiNP_113712.1. NM_031524.1.
UniGeneiRn.198230.

Genome annotation databases

GeneIDi24628.
KEGGirno:24628.
UCSCiRGD:3283. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14117 mRNA. Translation: CAA78487.1.
L40991 mRNA. Translation: AAA70048.1.
PIRiS25097.
RefSeqiNP_113712.1. NM_031524.1.
UniGeneiRn.198230.

3D structure databases

ProteinModelPortaliQ05028.
SMRiQ05028. Positions 81-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023196.

PTM databases

PhosphoSiteiQ05028.

Proteomic databases

PaxDbiQ05028.
PRIDEiQ05028.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24628.
KEGGirno:24628.
UCSCiRGD:3283. rat.

Organism-specific databases

CTDi5155.
RGDi3283. Pdgfb.

Phylogenomic databases

eggNOGiENOG410IJ45. Eukaryota.
ENOG410XWTB. LUCA.
HOGENOMiHOG000286027.
HOVERGENiHBG053546.
InParanoidiQ05028.
KOiK17386.
PhylomeDBiQ05028.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR006782. PDGF_N.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF04692. PDGF_N. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Conservation in sequence and affinity of human and rodent PDGF ligands and receptors."
    Herren B., Weyer K.A., Rouge M., Loetscher P., Pech M.
    Biochim. Biophys. Acta 1173:294-302(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A subpopulation of smooth muscle cells in injured rat arteries expresses platelet-derived growth factor-B chain mRNA."
    Lindner V., Giachelli C.M., Schwartz S.M., Reidy M.A.
    Circ. Res. 76:951-957(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 74-182.
    Strain: Sprague-Dawley.
    Tissue: Smooth muscle.

Entry informationi

Entry nameiPDGFB_RAT
AccessioniPrimary (citable) accession number: Q05028
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 8, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.