ID   GALE_NEIGO              Reviewed;         338 AA.
AC   Q05026;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   16-JUN-2009, entry version 50.
DE   RecName: Full=UDP-glucose 4-epimerase;
DE            EC=5.1.3.2;
DE   AltName: Full=UDP-galactose 4-epimerase;
DE   AltName: Full=Galactowaldenase;
GN   Name=galE;
OS   Neisseria gonorrhoeae.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC   Neisseriaceae; Neisseria.
OX   NCBI_TaxID=485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MS11;
RX   MEDLINE=93360819; PubMed=8355614;
RX   DOI=10.1111/j.1365-2958.1993.tb01635.x;
RA   Robertson B.D., Frosch M., van Putten J.P.M.;
RT   "The role of galE in the biosynthesis and function of gonococcal
RT   lipopolysaccharide.";
RL   Mol. Microbiol. 8:891-901(1993).
CC   -!- FUNCTION: Plays an essential role in the incorporation of
CC       galactose into meningococcal lipopolysaccharide surface molecules,
CC       which are important for pathogenesis.
CC   -!- CATALYTIC ACTIVITY: UDP-glucose = UDP-galactose.
CC   -!- COFACTOR: NAD.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the sugar epimerase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; Z21508; CAA79721.1; -; Genomic_DNA.
DR   PIR; S34984; S34984.
DR   HSSP; P09147; 1XEL.
DR   BRENDA; 5.1.3.2; 588.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:EC.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR005886; GalE.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR008089; Nuc_sugar_epim.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR10366:SF39; GalE; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   PRINTS; PR01713; NUCEPIMERASE.
DR   TIGRFAMs; TIGR01179; galE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Galactose metabolism; Isomerase; NAD.
FT   CHAIN         1    338       UDP-glucose 4-epimerase.
FT                                /FTId=PRO_0000183211.
FT   NP_BIND       2     33       NAD (By similarity).
FT   ACT_SITE    149    149       Proton acceptor (By similarity).
FT   BINDING     124    124       Substrate (By similarity).
SQ   SEQUENCE   338 AA;  36885 MW;  C6A905035A083984 CRC64;
     MTVLITGGTG FIGSHTAVSL VQSGYDAVIL DNLCNSSAAV LPRLRQITGR NIPFYQGDIR
     DCQILRQIFS EHEIESVIHF AGLKAVGESV AEPTKYYGNN VYGSLVLAEE MARAGVLKIV
     FSSSATVYGD AEKVPYTEDM RPGDTANPYG ASKAMVERML TDIQKADPRW SVILLRYFNP
     IGAHESGLIG EQPNGVPNNL LPYICQVASG RLPQLSVFGG DYPTPDGTGM RDYIHVMDLA
     EGHIAAMKAK GGVAGVHLFN LGSGRAYSVL EIIRAFEAAS GLHIPYRIQP RRAGDLACSY
     ADPSHTKQQT GWETKRGLQQ MMEDSWRWVS RNPGRYGD
//