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Protein

Transcription initiation factor TFIID subunit 7

Gene

TAF7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. TAF7 is responsible for the recruitment of BDF1 to TATA element containing promoters.4 Publications

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • RNA polymerase II transcriptional preinitiation complex assembly Source: SGD
  • transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32908-MONOMER.
ReactomeiR-SCE-674695. RNA Polymerase II Pre-transcription Events.
R-SCE-73776. RNA Polymerase II Promoter Escape.
R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SCE-75953. RNA Polymerase II Transcription Initiation.
R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 7
Alternative name(s):
TAFII-67
TBP-associated factor 67 kDa
TBP-associated factor 7
Gene namesi
Name:TAF7
Synonyms:TAF67
Ordered Locus Names:YMR227C
ORF Names:YM9959.09C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR227C.
SGDiS000004840. TAF7.

Subcellular locationi

GO - Cellular componenti

  • transcription factor TFIID complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188851 – 590Transcription initiation factor TFIID subunit 7Add BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99PhosphotyrosineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ05021.
PRIDEiQ05021.

PTM databases

iPTMnetiQ05021.

Interactioni

Subunit structurei

TAF7 interacts with BDF1. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BDF1P358175EBI-27490,EBI-3493

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35405. 82 interactors.
DIPiDIP-6818N.
IntActiQ05021. 13 interactors.
MINTiMINT-636201.

Structurei

Secondary structure

1590
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi97 – 100Combined sources4
Beta strandi112 – 119Combined sources8
Helixi126 – 135Combined sources10
Beta strandi141 – 145Combined sources5
Beta strandi147 – 155Combined sources9
Beta strandi158 – 175Combined sources18
Beta strandi177 – 197Combined sources21
Helixi201 – 204Combined sources4
Turni215 – 219Combined sources5
Helixi221 – 223Combined sources3
Helixi224 – 234Combined sources11
Helixi238 – 240Combined sources3
Helixi245 – 249Combined sources5
Helixi251 – 256Combined sources6
Helixi267 – 269Combined sources3
Turni270 – 276Combined sources7
Helixi283 – 301Combined sources19
Beta strandi302 – 311Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OY2X-ray2.90B/D/F86-320[»]
ProteinModelPortaliQ05021.
SMRiQ05021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili427 – 549Sequence analysisAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 90Lys-richAdd BLAST84
Compositional biasi200 – 203Poly-Glu4
Compositional biasi304 – 571Asp/Glu-richAdd BLAST268

Sequence similaritiesi

Belongs to the TAF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000010815.
HOGENOMiHOG000142022.
InParanoidiQ05021.
KOiK03132.
OMAiDVCQMLL.
OrthoDBiEOG092C3WW5.

Family and domain databases

CDDicd08047. TAF7. 1 hit.
InterProiIPR006751. TAFII55_prot_cons_reg.
[Graphical view]
PfamiPF04658. TAFII55_N. 1 hit.
[Graphical view]
SMARTiSM01370. TAFII55_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVIRIKKPR GPGEKDQPLE GEPKLKRIRI KTKVTDEDIK PKPKLKINLK
60 70 80 90 100
KKKESADGKE KKNSLKLKLN LKKNEEPVKK IHKAPKLRLK PIRIPGEAYD
110 120 130 140 150
SEASDIEDDP LIESGVILRI LPDIQLEFVK NSLESGDYSG ISIKWKNERH
160 170 180 190 200
AVVTINDVMY GAILVDLPTV IEVNKSVDRK NLLKTFDVSQ MLLCIRPIQE
210 220 230 240 250
EEEVYALEAP DTEDLVVKHF EGIEDEIWEN KETFLKGYNG APLSDMEAKH
260 270 280 290 300
LKEIALKGYD YKHGISPPLY NVRNRRFRRK MDPNEIDYVE KVVDMLLKQD
310 320 330 340 350
KQAEEVSYDL VDKSELQARQ ERVSSWENFK EEPGEPLSRP ALKKEEIHTI
360 370 380 390 400
ASAVGKQGAE EEGEEGMEEE EEEDLDLGAA FESEEEGSGA EGDKEQQQEE
410 420 430 440 450
VGDEVDQDTG GEDDDDDDDG DIEAAGGESE SDDEKDENRQ HTELLADELN
460 470 480 490 500
ELETTLAHTK HKLSKATNPL LKSRFIDSIK KLEKEAELKR KQLQQTEDSV
510 520 530 540 550
QKQHQHRSDA ETANNVEEEE EEEEEEEEED EVDEDEEDDE ENDEDEDNVH
560 570 580 590
EREHIQENKV VRELDEAPAE ETLDQNDLDM MMLFGAEGDE
Length:590
Mass (Da):67,555
Last modified:November 1, 1997 - v1
Checksum:iC014E7419B0B1C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49939 Genomic DNA. Translation: CAA90198.1.
BK006946 Genomic DNA. Translation: DAA10126.1.
PIRiS57594.
RefSeqiNP_013954.1. NM_001182734.1.

Genome annotation databases

EnsemblFungiiYMR227C; YMR227C; YMR227C.
GeneIDi855267.
KEGGisce:YMR227C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49939 Genomic DNA. Translation: CAA90198.1.
BK006946 Genomic DNA. Translation: DAA10126.1.
PIRiS57594.
RefSeqiNP_013954.1. NM_001182734.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OY2X-ray2.90B/D/F86-320[»]
ProteinModelPortaliQ05021.
SMRiQ05021.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35405. 82 interactors.
DIPiDIP-6818N.
IntActiQ05021. 13 interactors.
MINTiMINT-636201.

PTM databases

iPTMnetiQ05021.

Proteomic databases

MaxQBiQ05021.
PRIDEiQ05021.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR227C; YMR227C; YMR227C.
GeneIDi855267.
KEGGisce:YMR227C.

Organism-specific databases

EuPathDBiFungiDB:YMR227C.
SGDiS000004840. TAF7.

Phylogenomic databases

GeneTreeiENSGT00390000010815.
HOGENOMiHOG000142022.
InParanoidiQ05021.
KOiK03132.
OMAiDVCQMLL.
OrthoDBiEOG092C3WW5.

Enzyme and pathway databases

BioCyciYEAST:G3O-32908-MONOMER.
ReactomeiR-SCE-674695. RNA Polymerase II Pre-transcription Events.
R-SCE-73776. RNA Polymerase II Promoter Escape.
R-SCE-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SCE-75953. RNA Polymerase II Transcription Initiation.
R-SCE-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

PROiQ05021.

Family and domain databases

CDDicd08047. TAF7. 1 hit.
InterProiIPR006751. TAFII55_prot_cons_reg.
[Graphical view]
PfamiPF04658. TAFII55_N. 1 hit.
[Graphical view]
SMARTiSM01370. TAFII55_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAF7_YEAST
AccessioniPrimary (citable) accession number: Q05021
Secondary accession number(s): D6W052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1100 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.