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Q05020

- APOC2_MOUSE

UniProt

Q05020 - APOC2_MOUSE

Protein

Apolipoprotein C-II

Gene

Apoc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

    GO - Molecular functioni

    1. lipase inhibitor activity Source: Ensembl
    2. lipid binding Source: Ensembl
    3. lipoprotein lipase activator activity Source: Ensembl
    4. phospholipase activator activity Source: Ensembl

    GO - Biological processi

    1. cholesterol efflux Source: Ensembl
    2. chylomicron remnant clearance Source: Ensembl
    3. high-density lipoprotein particle clearance Source: Ensembl
    4. lipid catabolic process Source: UniProtKB-KW
    5. lipoprotein transport Source: Ensembl
    6. negative regulation of cholesterol transport Source: Ensembl
    7. negative regulation of lipid metabolic process Source: Ensembl
    8. negative regulation of receptor-mediated endocytosis Source: Ensembl
    9. negative regulation of very-low-density lipoprotein particle clearance Source: Ensembl
    10. phospholipid efflux Source: Ensembl
    11. positive regulation of fatty acid biosynthetic process Source: Ensembl
    12. positive regulation of lipoprotein lipase activity Source: Ensembl
    13. positive regulation of phospholipase activity Source: Ensembl
    14. positive regulation of phospholipid catabolic process Source: Ensembl
    15. positive regulation of triglyceride catabolic process Source: Ensembl
    16. response to drug Source: Ensembl
    17. triglyceride homeostasis Source: Ensembl

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism, Lipid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198569. Retinoid metabolism and transport.
    REACT_213857. HDL-mediated lipid transport.
    REACT_216017. Chylomicron-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein C-II
    Short name:
    Apo-CII
    Short name:
    ApoC-II
    Alternative name(s):
    Apolipoprotein C2
    Gene namesi
    Name:Apoc2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:88054. Apoc2.

    Subcellular locationi

    GO - Cellular componenti

    1. chylomicron Source: UniProtKB-KW
    2. cytosol Source: Reactome
    3. extracellular region Source: Reactome
    4. intermediate-density lipoprotein particle Source: Ensembl
    5. low-density lipoprotein particle Source: Ensembl
    6. spherical high-density lipoprotein particle Source: Ensembl
    7. very-low-density lipoprotein particle Source: UniProtKB-KW

    Keywords - Cellular componenti

    Chylomicron, Secreted, VLDL

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 9775Apolipoprotein C-IIPRO_0000002026Add
    BLAST

    Proteomic databases

    PaxDbiQ05020.
    PRIDEiQ05020.

    PTM databases

    PhosphoSiteiQ05020.

    Expressioni

    Tissue specificityi

    Secreted in plasma.

    Gene expression databases

    ArrayExpressiQ05020.
    BgeeiQ05020.
    CleanExiMM_APOC2.
    GenevestigatoriQ05020.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000115173.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05020.
    SMRiQ05020. Positions 33-97.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni40 – 489Lipid bindingBy similarity
    Regioni52 – 7524Lipoprotein lipase cofactorBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the apolipoprotein C2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG25045.
    HOGENOMiHOG000034002.
    HOVERGENiHBG050548.
    InParanoidiQ05020.
    OMAiKIRDMYS.
    OrthoDBiEOG7TXKKM.
    PhylomeDBiQ05020.
    TreeFamiTF338218.

    Family and domain databases

    Gene3Di1.10.1440.10. 1 hit.
    InterProiIPR008019. Apo-CII.
    IPR023121. ApoC-II_domain.
    [Graphical view]
    PANTHERiPTHR16566. PTHR16566. 1 hit.
    PfamiPF05355. Apo-CII. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05020-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSRFFLALF LVILMLGNEV QGNQEDDSGS LALLGTVQGS LLSYWTSAKE   50
    VAKDLYQKTY PISMDEKLRD MYSKSSAAMS TYAGIFTDQL LTLLRGE 97
    Length:97
    Mass (Da):10,741
    Last modified:February 1, 1994 - v1
    Checksum:i18223E9034A1983E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti89 – 891Q → H in CAA80220. (PubMed:7691714)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z15090 mRNA. Translation: CAA78804.1.
    Z22216, Z22217 Genomic DNA. Translation: CAA80220.1.
    BC024697 mRNA. Translation: AAH24697.1.
    CCDSiCCDS39801.1.
    PIRiS31799.
    RefSeqiNP_001264873.1. NM_001277944.1.
    UniGeneiMm.28394.

    Genome annotation databases

    EnsembliENSMUST00000003074; ENSMUSP00000003074; ENSMUSG00000002992.
    ENSMUST00000134116; ENSMUSP00000118291; ENSMUSG00000002992.
    ENSMUST00000142352; ENSMUSP00000115173; ENSMUSG00000002992.
    ENSMUST00000150569; ENSMUSP00000114512; ENSMUSG00000002992.
    GeneIDi11813.
    KEGGimmu:11813.
    UCSCiuc009fmt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z15090 mRNA. Translation: CAA78804.1 .
    Z22216 , Z22217 Genomic DNA. Translation: CAA80220.1 .
    BC024697 mRNA. Translation: AAH24697.1 .
    CCDSi CCDS39801.1.
    PIRi S31799.
    RefSeqi NP_001264873.1. NM_001277944.1.
    UniGenei Mm.28394.

    3D structure databases

    ProteinModelPortali Q05020.
    SMRi Q05020. Positions 33-97.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000115173.

    PTM databases

    PhosphoSitei Q05020.

    Proteomic databases

    PaxDbi Q05020.
    PRIDEi Q05020.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003074 ; ENSMUSP00000003074 ; ENSMUSG00000002992 .
    ENSMUST00000134116 ; ENSMUSP00000118291 ; ENSMUSG00000002992 .
    ENSMUST00000142352 ; ENSMUSP00000115173 ; ENSMUSG00000002992 .
    ENSMUST00000150569 ; ENSMUSP00000114512 ; ENSMUSG00000002992 .
    GeneIDi 11813.
    KEGGi mmu:11813.
    UCSCi uc009fmt.2. mouse.

    Organism-specific databases

    CTDi 344.
    MGIi MGI:88054. Apoc2.

    Phylogenomic databases

    eggNOGi NOG25045.
    HOGENOMi HOG000034002.
    HOVERGENi HBG050548.
    InParanoidi Q05020.
    OMAi KIRDMYS.
    OrthoDBi EOG7TXKKM.
    PhylomeDBi Q05020.
    TreeFami TF338218.

    Enzyme and pathway databases

    Reactomei REACT_198569. Retinoid metabolism and transport.
    REACT_213857. HDL-mediated lipid transport.
    REACT_216017. Chylomicron-mediated lipid transport.

    Miscellaneous databases

    NextBioi 279691.
    PROi Q05020.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q05020.
    Bgeei Q05020.
    CleanExi MM_APOC2.
    Genevestigatori Q05020.

    Family and domain databases

    Gene3Di 1.10.1440.10. 1 hit.
    InterProi IPR008019. Apo-CII.
    IPR023121. ApoC-II_domain.
    [Graphical view ]
    PANTHERi PTHR16566. PTHR16566. 1 hit.
    Pfami PF05355. Apo-CII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary conservation of the mouse apolipoprotein E-C1-C2 gene cluster: structure and genetic variability in inbred mice."
      Hoffer M.J.V., Hofker M.H., van Eck M.M., Havekes L.M., Frants R.R.
      Genomics 15:62-67(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: C57BL/RIJ / 129/J.
      Tissue: Liver.
    2. "Structure and expression of the mouse apolipoprotein C2 gene."
      Hoffer M.J.V., van Eck M.M., Havekes L.M., Hofker M.H., Frants R.R.
      Genomics 17:45-51(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/RIJ.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiAPOC2_MOUSE
    AccessioniPrimary (citable) accession number: Q05020
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3