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Q05020

- APOC2_MOUSE

UniProt

Q05020 - APOC2_MOUSE

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Protein

Apolipoprotein C-II

Gene

Apoc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.By similarity

GO - Molecular functioni

  1. enzyme activator activity Source: InterPro

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. lipid transport Source: UniProtKB-KW
  3. lipoprotein transport Source: Ensembl
  4. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Lipid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198569. Retinoid metabolism and transport.
REACT_213857. HDL-mediated lipid transport.
REACT_216017. Chylomicron-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-II
Short name:
Apo-CII
Short name:
ApoC-II
Alternative name(s):
Apolipoprotein C2
Gene namesi
Name:Apoc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:88054. Apoc2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. chylomicron Source: UniProtKB-KW
  2. cytosol Source: Reactome
  3. extracellular region Source: Reactome
  4. very-low-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, HDL, LDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 9775Apolipoprotein C-IIPRO_0000002026Add
BLAST

Proteomic databases

PaxDbiQ05020.
PRIDEiQ05020.

PTM databases

PhosphoSiteiQ05020.

Expressioni

Tissue specificityi

Adult and fetal liver, intestine and peritoneal macrophages.1 Publication

Gene expression databases

BgeeiQ05020.
CleanExiMM_APOC2.
ExpressionAtlasiQ05020. baseline and differential.
GenevestigatoriQ05020.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115173.

Structurei

3D structure databases

ProteinModelPortaliQ05020.
SMRiQ05020. Positions 33-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 489Lipid bindingBy similarity
Regioni52 – 7524Lipoprotein lipase cofactorBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein C2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG25045.
HOGENOMiHOG000034002.
HOVERGENiHBG050548.
InParanoidiQ05020.
OMAiKIRDMYS.
OrthoDBiEOG7TXKKM.
PhylomeDBiQ05020.
TreeFamiTF338218.

Family and domain databases

Gene3Di1.10.1440.10. 1 hit.
InterProiIPR008019. Apo-CII.
IPR023121. ApoC-II_domain.
[Graphical view]
PANTHERiPTHR16566. PTHR16566. 1 hit.
PfamiPF05355. Apo-CII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05020-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSRFFLALF LVILMLGNEV QGNQEDDSGS LALLGTVQGS LLSYWTSAKE
60 70 80 90
VAKDLYQKTY PISMDEKLRD MYSKSSAAMS TYAGIFTDQL LTLLRGE
Length:97
Mass (Da):10,741
Last modified:February 1, 1994 - v1
Checksum:i18223E9034A1983E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891Q → H in CAA80220. (PubMed:7691714)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15090 mRNA. Translation: CAA78804.1.
Z22216, Z22217 Genomic DNA. Translation: CAA80220.1.
BC024697 mRNA. Translation: AAH24697.1.
CCDSiCCDS39801.1.
PIRiS31799.
RefSeqiNP_001264873.1. NM_001277944.1.
UniGeneiMm.28394.

Genome annotation databases

EnsembliENSMUST00000003074; ENSMUSP00000003074; ENSMUSG00000002992.
ENSMUST00000134116; ENSMUSP00000118291; ENSMUSG00000002992.
ENSMUST00000142352; ENSMUSP00000115173; ENSMUSG00000002992.
ENSMUST00000150569; ENSMUSP00000114512; ENSMUSG00000002992.
GeneIDi11813.
KEGGimmu:11813.
UCSCiuc009fmt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15090 mRNA. Translation: CAA78804.1 .
Z22216 , Z22217 Genomic DNA. Translation: CAA80220.1 .
BC024697 mRNA. Translation: AAH24697.1 .
CCDSi CCDS39801.1.
PIRi S31799.
RefSeqi NP_001264873.1. NM_001277944.1.
UniGenei Mm.28394.

3D structure databases

ProteinModelPortali Q05020.
SMRi Q05020. Positions 33-97.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000115173.

PTM databases

PhosphoSitei Q05020.

Proteomic databases

PaxDbi Q05020.
PRIDEi Q05020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003074 ; ENSMUSP00000003074 ; ENSMUSG00000002992 .
ENSMUST00000134116 ; ENSMUSP00000118291 ; ENSMUSG00000002992 .
ENSMUST00000142352 ; ENSMUSP00000115173 ; ENSMUSG00000002992 .
ENSMUST00000150569 ; ENSMUSP00000114512 ; ENSMUSG00000002992 .
GeneIDi 11813.
KEGGi mmu:11813.
UCSCi uc009fmt.2. mouse.

Organism-specific databases

CTDi 344.
MGIi MGI:88054. Apoc2.

Phylogenomic databases

eggNOGi NOG25045.
HOGENOMi HOG000034002.
HOVERGENi HBG050548.
InParanoidi Q05020.
OMAi KIRDMYS.
OrthoDBi EOG7TXKKM.
PhylomeDBi Q05020.
TreeFami TF338218.

Enzyme and pathway databases

Reactomei REACT_198569. Retinoid metabolism and transport.
REACT_213857. HDL-mediated lipid transport.
REACT_216017. Chylomicron-mediated lipid transport.

Miscellaneous databases

NextBioi 279691.
PROi Q05020.
SOURCEi Search...

Gene expression databases

Bgeei Q05020.
CleanExi MM_APOC2.
ExpressionAtlasi Q05020. baseline and differential.
Genevestigatori Q05020.

Family and domain databases

Gene3Di 1.10.1440.10. 1 hit.
InterProi IPR008019. Apo-CII.
IPR023121. ApoC-II_domain.
[Graphical view ]
PANTHERi PTHR16566. PTHR16566. 1 hit.
Pfami PF05355. Apo-CII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary conservation of the mouse apolipoprotein E-C1-C2 gene cluster: structure and genetic variability in inbred mice."
    Hoffer M.J.V., Hofker M.H., van Eck M.M., Havekes L.M., Frants R.R.
    Genomics 15:62-67(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: C57BL/RIJ / 129/J.
    Tissue: Liver.
  2. "Structure and expression of the mouse apolipoprotein C2 gene."
    Hoffer M.J.V., van Eck M.M., Havekes L.M., Hofker M.H., Frants R.R.
    Genomics 17:45-51(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: C57BL/RIJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiAPOC2_MOUSE
AccessioniPrimary (citable) accession number: Q05020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3