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Q05020 (APOC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein C-II

Short name=Apo-CII
Short name=ApoC-II
Alternative name(s):
Apolipoprotein C2
Gene names
Name:Apoc2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

Subcellular location

Secreted.

Tissue specificity

Secreted in plasma.

Sequence similarities

Belongs to the apolipoprotein C2 family.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
Lipid transport
Transport
   Cellular componentChylomicron
Secreted
VLDL
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcholesterol efflux

Inferred from electronic annotation. Source: Ensembl

chylomicron remnant clearance

Inferred from electronic annotation. Source: Ensembl

high-density lipoprotein particle clearance

Inferred from electronic annotation. Source: Ensembl

lipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

lipoprotein transport

Inferred from electronic annotation. Source: Ensembl

negative regulation of cholesterol transport

Inferred from electronic annotation. Source: Ensembl

negative regulation of lipid metabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of receptor-mediated endocytosis

Inferred from electronic annotation. Source: Ensembl

negative regulation of very-low-density lipoprotein particle clearance

Inferred from electronic annotation. Source: Ensembl

phospholipid efflux

Inferred from electronic annotation. Source: Ensembl

positive regulation of fatty acid biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of lipoprotein lipase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of phospholipase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of phospholipid catabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of triglyceride catabolic process

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

triglyceride homeostasis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentchylomicron

Inferred from electronic annotation. Source: UniProtKB-KW

cytosol

Traceable author statement. Source: Reactome

extracellular region

Traceable author statement. Source: Reactome

intermediate-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

spherical high-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

very-low-density lipoprotein particle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipase inhibitor activity

Inferred from electronic annotation. Source: Ensembl

lipid binding

Inferred from electronic annotation. Source: Ensembl

lipoprotein lipase activator activity

Inferred from electronic annotation. Source: Ensembl

phospholipase activator activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 9775Apolipoprotein C-II
PRO_0000002026

Regions

Region40 – 489Lipid binding By similarity
Region52 – 7524Lipoprotein lipase cofactor By similarity

Experimental info

Sequence conflict891Q → H in CAA80220. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q05020 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: 18223E9034A1983E

FASTA9710,741
        10         20         30         40         50         60 
MGSRFFLALF LVILMLGNEV QGNQEDDSGS LALLGTVQGS LLSYWTSAKE VAKDLYQKTY 

        70         80         90 
PISMDEKLRD MYSKSSAAMS TYAGIFTDQL LTLLRGE 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary conservation of the mouse apolipoprotein E-C1-C2 gene cluster: structure and genetic variability in inbred mice."
Hoffer M.J.V., Hofker M.H., van Eck M.M., Havekes L.M., Frants R.R.
Genomics 15:62-67(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: C57BL/RIJ / 129/J.
Tissue: Liver.
[2]"Structure and expression of the mouse apolipoprotein C2 gene."
Hoffer M.J.V., van Eck M.M., Havekes L.M., Hofker M.H., Frants R.R.
Genomics 17:45-51(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/RIJ.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z15090 mRNA. Translation: CAA78804.1.
Z22216, Z22217 Genomic DNA. Translation: CAA80220.1.
BC024697 mRNA. Translation: AAH24697.1.
CCDSCCDS39801.1.
PIRS31799.
RefSeqNP_001264873.1. NM_001277944.1.
UniGeneMm.28394.

3D structure databases

ProteinModelPortalQ05020.
SMRQ05020. Positions 33-97.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000115173.

PTM databases

PhosphoSiteQ05020.

Proteomic databases

PaxDbQ05020.
PRIDEQ05020.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003074; ENSMUSP00000003074; ENSMUSG00000002992.
ENSMUST00000134116; ENSMUSP00000118291; ENSMUSG00000002992.
ENSMUST00000142352; ENSMUSP00000115173; ENSMUSG00000002992.
ENSMUST00000150569; ENSMUSP00000114512; ENSMUSG00000002992.
GeneID11813.
KEGGmmu:11813.
UCSCuc009fmt.2. mouse.

Organism-specific databases

CTD344.
MGIMGI:88054. Apoc2.

Phylogenomic databases

eggNOGNOG25045.
HOGENOMHOG000034002.
HOVERGENHBG050548.
InParanoidQ05020.
OMAKIRDMYS.
OrthoDBEOG7TXKKM.
PhylomeDBQ05020.
TreeFamTF338218.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.
REACT_189085. Disease.

Gene expression databases

ArrayExpressQ05020.
BgeeQ05020.
CleanExMM_APOC2.
GenevestigatorQ05020.

Family and domain databases

Gene3D1.10.1440.10. 1 hit.
InterProIPR008019. Apo-CII.
IPR023121. ApoC-II_domain.
[Graphical view]
PANTHERPTHR16566. PTHR16566. 1 hit.
PfamPF05355. Apo-CII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio279691.
PROQ05020.
SOURCESearch...

Entry information

Entry nameAPOC2_MOUSE
AccessionPrimary (citable) accession number: Q05020
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot