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Protein

Apolipoprotein C-II

Gene

Apoc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid degradation, Lipid metabolism, Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8963888 Chylomicron assembly
R-MMU-8963901 Chylomicron remodeling
R-MMU-8964058 HDL remodeling
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-II
Short name:
Apo-CII
Short name:
ApoC-II
Alternative name(s):
Apolipoprotein C2
Gene namesi
Name:Apoc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88054 Apoc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, HDL, LDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000202623 – 97Apolipoprotein C-IIAdd BLAST75

Proteomic databases

PaxDbiQ05020
PeptideAtlasiQ05020
PRIDEiQ05020

PTM databases

iPTMnetiQ05020
PhosphoSitePlusiQ05020

Expressioni

Tissue specificityi

Adult and fetal liver, intestine and peritoneal macrophages.1 Publication

Gene expression databases

BgeeiENSMUSG00000002992
CleanExiMM_APOC2
ExpressionAtlasiQ05020 baseline and differential
GenevisibleiQ05020 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003074

Structurei

3D structure databases

ProteinModelPortaliQ05020
SMRiQ05020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 71Lipid bindingBy similarity9
Regioni75 – 97Lipoprotein lipase cofactorBy similarityAdd BLAST23

Sequence similaritiesi

Belongs to the apolipoprotein C2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3QQ Eukaryota
ENOG4111AXD LUCA
GeneTreeiENSGT00390000007913
HOGENOMiHOG000034002
HOVERGENiHBG050548
InParanoidiQ05020
KOiK22287
OMAiYWESAKA
OrthoDBiEOG091G17WL
PhylomeDBiQ05020
TreeFamiTF338218

Family and domain databases

Gene3Di1.10.1440.10, 1 hit
InterProiView protein in InterPro
IPR008019 Apo-CII
IPR023121 ApoC-II_dom_sf
PANTHERiPTHR16566 PTHR16566, 1 hit
PfamiView protein in Pfam
PF05355 Apo-CII, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSRFFLALF LVILMLGNEV QGNQEDDSGS LALLGTVQGS LLSYWTSAKE
60 70 80 90
VAKDLYQKTY PISMDEKLRD MYSKSSAAMS TYAGIFTDQL LTLLRGE
Length:97
Mass (Da):10,741
Last modified:February 1, 1994 - v1
Checksum:i18223E9034A1983E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89Q → H in CAA80220 (PubMed:7691714).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15090 mRNA Translation: CAA78804.1
Z22216, Z22217 Genomic DNA Translation: CAA80220.1
BC024697 mRNA Translation: AAH24697.1
CCDSiCCDS39801.1
PIRiS31799
RefSeqiNP_001264873.1, NM_001277944.1
NP_001296724.1, NM_001309795.1
NP_001296728.1, NM_001309799.1
UniGeneiMm.28394

Genome annotation databases

EnsembliENSMUST00000003074; ENSMUSP00000003074; ENSMUSG00000002992
ENSMUST00000127648; ENSMUSP00000118305; ENSMUSG00000109350
ENSMUST00000134116; ENSMUSP00000118291; ENSMUSG00000002992
ENSMUST00000142352; ENSMUSP00000115173; ENSMUSG00000002992
ENSMUST00000150569; ENSMUSP00000114512; ENSMUSG00000109350
GeneIDi105886299
11813
KEGGimmu:105886299
mmu:11813
UCSCiuc009fmt.3 mouse

Similar proteinsi

Entry informationi

Entry nameiAPOC2_MOUSE
AccessioniPrimary (citable) accession number: Q05020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 25, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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