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Q05020

- APOC2_MOUSE

UniProt

Q05020 - APOC2_MOUSE

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Protein
Apolipoprotein C-II
Gene
Apoc2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

GO - Molecular functioni

  1. lipase inhibitor activity Source: Ensembl
  2. lipid binding Source: Ensembl
  3. lipoprotein lipase activator activity Source: Ensembl
  4. phospholipase activator activity Source: Ensembl

GO - Biological processi

  1. cholesterol efflux Source: Ensembl
  2. chylomicron remnant clearance Source: Ensembl
  3. high-density lipoprotein particle clearance Source: Ensembl
  4. lipid catabolic process Source: UniProtKB-KW
  5. lipoprotein transport Source: Ensembl
  6. negative regulation of cholesterol transport Source: Ensembl
  7. negative regulation of lipid metabolic process Source: Ensembl
  8. negative regulation of receptor-mediated endocytosis Source: Ensembl
  9. negative regulation of very-low-density lipoprotein particle clearance Source: Ensembl
  10. phospholipid efflux Source: Ensembl
  11. positive regulation of fatty acid biosynthetic process Source: Ensembl
  12. positive regulation of lipoprotein lipase activity Source: Ensembl
  13. positive regulation of phospholipase activity Source: Ensembl
  14. positive regulation of phospholipid catabolic process Source: Ensembl
  15. positive regulation of triglyceride catabolic process Source: Ensembl
  16. response to drug Source: Ensembl
  17. triglyceride homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Lipid transport, Transport

Enzyme and pathway databases

ReactomeiREACT_198569. Retinoid metabolism and transport.
REACT_213857. HDL-mediated lipid transport.
REACT_216017. Chylomicron-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-II
Short name:
Apo-CII
Short name:
ApoC-II
Alternative name(s):
Apolipoprotein C2
Gene namesi
Name:Apoc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:88054. Apoc2.

Subcellular locationi

GO - Cellular componenti

  1. chylomicron Source: UniProtKB-KW
  2. cytosol Source: Reactome
  3. extracellular region Source: Reactome
  4. intermediate-density lipoprotein particle Source: Ensembl
  5. low-density lipoprotein particle Source: Ensembl
  6. spherical high-density lipoprotein particle Source: Ensembl
  7. very-low-density lipoprotein particle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarity
Add
BLAST
Chaini23 – 9775Apolipoprotein C-II
PRO_0000002026Add
BLAST

Proteomic databases

PaxDbiQ05020.
PRIDEiQ05020.

PTM databases

PhosphoSiteiQ05020.

Expressioni

Tissue specificityi

Secreted in plasma.

Gene expression databases

ArrayExpressiQ05020.
BgeeiQ05020.
CleanExiMM_APOC2.
GenevestigatoriQ05020.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000115173.

Structurei

3D structure databases

ProteinModelPortaliQ05020.
SMRiQ05020. Positions 33-97.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 489Lipid binding By similarity
Regioni52 – 7524Lipoprotein lipase cofactor By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein C2 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG25045.
HOGENOMiHOG000034002.
HOVERGENiHBG050548.
InParanoidiQ05020.
OMAiKIRDMYS.
OrthoDBiEOG7TXKKM.
PhylomeDBiQ05020.
TreeFamiTF338218.

Family and domain databases

Gene3Di1.10.1440.10. 1 hit.
InterProiIPR008019. Apo-CII.
IPR023121. ApoC-II_domain.
[Graphical view]
PANTHERiPTHR16566. PTHR16566. 1 hit.
PfamiPF05355. Apo-CII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05020-1 [UniParc]FASTAAdd to Basket

« Hide

MGSRFFLALF LVILMLGNEV QGNQEDDSGS LALLGTVQGS LLSYWTSAKE   50
VAKDLYQKTY PISMDEKLRD MYSKSSAAMS TYAGIFTDQL LTLLRGE 97
Length:97
Mass (Da):10,741
Last modified:February 1, 1994 - v1
Checksum:i18223E9034A1983E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891Q → H in CAA80220. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z15090 mRNA. Translation: CAA78804.1.
Z22216, Z22217 Genomic DNA. Translation: CAA80220.1.
BC024697 mRNA. Translation: AAH24697.1.
CCDSiCCDS39801.1.
PIRiS31799.
RefSeqiNP_001264873.1. NM_001277944.1.
UniGeneiMm.28394.

Genome annotation databases

EnsembliENSMUST00000003074; ENSMUSP00000003074; ENSMUSG00000002992.
ENSMUST00000134116; ENSMUSP00000118291; ENSMUSG00000002992.
ENSMUST00000142352; ENSMUSP00000115173; ENSMUSG00000002992.
ENSMUST00000150569; ENSMUSP00000114512; ENSMUSG00000002992.
GeneIDi11813.
KEGGimmu:11813.
UCSCiuc009fmt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z15090 mRNA. Translation: CAA78804.1 .
Z22216 , Z22217 Genomic DNA. Translation: CAA80220.1 .
BC024697 mRNA. Translation: AAH24697.1 .
CCDSi CCDS39801.1.
PIRi S31799.
RefSeqi NP_001264873.1. NM_001277944.1.
UniGenei Mm.28394.

3D structure databases

ProteinModelPortali Q05020.
SMRi Q05020. Positions 33-97.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000115173.

PTM databases

PhosphoSitei Q05020.

Proteomic databases

PaxDbi Q05020.
PRIDEi Q05020.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003074 ; ENSMUSP00000003074 ; ENSMUSG00000002992 .
ENSMUST00000134116 ; ENSMUSP00000118291 ; ENSMUSG00000002992 .
ENSMUST00000142352 ; ENSMUSP00000115173 ; ENSMUSG00000002992 .
ENSMUST00000150569 ; ENSMUSP00000114512 ; ENSMUSG00000002992 .
GeneIDi 11813.
KEGGi mmu:11813.
UCSCi uc009fmt.2. mouse.

Organism-specific databases

CTDi 344.
MGIi MGI:88054. Apoc2.

Phylogenomic databases

eggNOGi NOG25045.
HOGENOMi HOG000034002.
HOVERGENi HBG050548.
InParanoidi Q05020.
OMAi KIRDMYS.
OrthoDBi EOG7TXKKM.
PhylomeDBi Q05020.
TreeFami TF338218.

Enzyme and pathway databases

Reactomei REACT_198569. Retinoid metabolism and transport.
REACT_213857. HDL-mediated lipid transport.
REACT_216017. Chylomicron-mediated lipid transport.

Miscellaneous databases

NextBioi 279691.
PROi Q05020.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q05020.
Bgeei Q05020.
CleanExi MM_APOC2.
Genevestigatori Q05020.

Family and domain databases

Gene3Di 1.10.1440.10. 1 hit.
InterProi IPR008019. Apo-CII.
IPR023121. ApoC-II_domain.
[Graphical view ]
PANTHERi PTHR16566. PTHR16566. 1 hit.
Pfami PF05355. Apo-CII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary conservation of the mouse apolipoprotein E-C1-C2 gene cluster: structure and genetic variability in inbred mice."
    Hoffer M.J.V., Hofker M.H., van Eck M.M., Havekes L.M., Frants R.R.
    Genomics 15:62-67(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: C57BL/RIJ / 129/J.
    Tissue: Liver.
  2. "Structure and expression of the mouse apolipoprotein C2 gene."
    Hoffer M.J.V., van Eck M.M., Havekes L.M., Hofker M.H., Frants R.R.
    Genomics 17:45-51(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/RIJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiAPOC2_MOUSE
AccessioniPrimary (citable) accession number: Q05020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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