Q05020 (APOC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apolipoprotein C-II
Short name=Apo-CII
Short name=ApoC-II

Alternative name(s):
Apolipoprotein C2

Gene names

Name:

Apoc2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	97 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.
Subcellular location	Secreted.
Tissue specificity	Secreted in plasma.
Sequence similarities	Belongs to the apolipoprotein C2 family.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism Lipid transport Transport
Cellular component	Chylomicron Secreted VLDL
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cholesterol efflux Inferred from electronic annotation. Source: Compara chylomicron remnant clearance Inferred from electronic annotation. Source: Compara high-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipoprotein transport Inferred from electronic annotation. Source: Compara negative regulation of cholesterol transport Inferred from electronic annotation. Source: Compara negative regulation of lipid metabolic process Inferred from electronic annotation. Source: Compara negative regulation of receptor-mediated endocytosis Inferred from electronic annotation. Source: Compara negative regulation of very-low-density lipoprotein particle clearance Inferred from electronic annotation. Source: Compara phospholipid efflux Inferred from electronic annotation. Source: Compara positive regulation of fatty acid biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of lipoprotein lipase activity Inferred from electronic annotation. Source: Compara positive regulation of phospholipase activity Inferred from electronic annotation. Source: Compara positive regulation of phospholipid catabolic process Inferred from electronic annotation. Source: Compara positive regulation of triglyceride catabolic process Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara triglyceride homeostasis Inferred from electronic annotation. Source: Compara
Cellular_component	chylomicron Inferred from electronic annotation. Source: UniProtKB-KW intermediate-density lipoprotein particle Inferred from electronic annotation. Source: Compara low-density lipoprotein particle Inferred from electronic annotation. Source: Compara spherical high-density lipoprotein particle Inferred from electronic annotation. Source: Compara very-low-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	lipase inhibitor activity Inferred from electronic annotation. Source: Compara lipid binding Inferred from electronic annotation. Source: Compara lipoprotein lipase activator activity Inferred from electronic annotation. Source: Compara phospholipase activator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	By similarity
	Chain	23 – 97	75	Apolipoprotein C-II		PRO_0000002026
Regions
	Region	40 – 48	9	Lipid binding By similarity
	Region	52 – 75	24	Lipoprotein lipase cofactor By similarity
Experimental info
	Sequence conflict	89	1	Q → H in CAA80220. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q05020 [UniParc]. Last modified February 1, 1994. Version 1. Checksum: 18223E9034A1983E	FASTA	97	10,741
	10 20 30 40 50 60 MGSRFFLALF LVILMLGNEV QGNQEDDSGS LALLGTVQGS LLSYWTSAKE VAKDLYQKTY 70 80 90 PISMDEKLRD MYSKSSAAMS TYAGIFTDQL LTLLRGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary conservation of the mouse apolipoprotein E-C1-C2 gene cluster: structure and genetic variability in inbred mice." Hoffer M.J.V., Hofker M.H., van Eck M.M., Havekes L.M., Frants R.R. Genomics 15:62-67(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: C57BL/RIJ / 129/J. Tissue: Liver.
[2]	"Structure and expression of the mouse apolipoprotein C2 gene." Hoffer M.J.V., van Eck M.M., Havekes L.M., Hofker M.H., Frants R.R. Genomics 17:45-51(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/RIJ.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z15090 mRNA. Translation: CAA78804.1. Z22216, Z22217 Genomic DNA. Translation: CAA80220.1. BC024697 mRNA. Translation: AAH24697.1.
IPI	IPI00136266.
PIR	S31799.
RefSeq	NP_033825.1. NM_009695.3.
UniGene	Mm.28394.
3D structure databases
ProteinModelPortal	Q05020.
SMR	Q05020. Positions 33-97.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000115173.
PTM databases
PhosphoSite	Q05020.
Proteomic databases
PaxDb	Q05020.
PRIDE	Q05020.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000003074; ENSMUSP00000003074; ENSMUSG00000002992. ENSMUST00000134116; ENSMUSP00000118291; ENSMUSG00000002992. ENSMUST00000142352; ENSMUSP00000115173; ENSMUSG00000002992. ENSMUST00000150569; ENSMUSP00000114512; ENSMUSG00000002992.
GeneID	11813.
KEGG	mmu:11813.
Organism-specific databases
CTD	344.
MGI	MGI:88054. Apoc2.
Phylogenomic databases
eggNOG	NOG25045.
HOGENOM	HOG000034002.
HOVERGEN	HBG050548.
InParanoid	Q05020.
OMA	GIFTDQV.
Gene expression databases
ArrayExpress	Q05020.
Bgee	Q05020.
CleanEx	MM_APOC2.
Genevestigator	Q05020.
GermOnline	ENSMUSG00000002992. Mus musculus.
Family and domain databases
Gene3D	1.10.1440.10. 1 hit.
InterPro	IPR008019. Apo-CII. IPR023121. ApoC-II_domain. [Graphical view]
PANTHER	PTHR16566. PTHR16566. 1 hit.
Pfam	PF05355. Apo-CII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	279691.
SOURCE	Search...

Entry information

Entry name

APOC2_MOUSE

Accession

Primary (citable) accession number: Q05020

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program