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Q05015 (FSH2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Family of serine hydrolases 2

EC=3.1.-.-
Gene names
Name:FSH2
Ordered Locus Names:YMR222C
ORF Names:YM9959.04C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serine hydrolase of unknown specificity. Ref.3

Subcellular location

Cytoplasm Ref.4.

Miscellaneous

Present with 1070 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the AB hydrolase 3 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Serine esterase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Family of serine hydrolases 2
PRO_0000212581

Sites

Active site1101Charge relay system By similarity
Active site1741Charge relay system By similarity
Active site2031Charge relay system By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05015 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: F7BE3BFCED4EC5B4

FASTA22324,534
        10         20         30         40         50         60 
MTKNVLMLHG LAQSGDYFAS KTKGFRAEME KLGYKLYYPT APNEFPPADV PDFLGEVIAD 

        70         80         90        100        110        120 
APGDGENTGV LAWLENDPST GGYFIPQTTI DYLHNYVLEN GPFAGIVGFS QGAGVAGYLA 

       130        140        150        160        170        180 
TDFNGLLGLT TEEQPPLEFF MAVSGFRFQP QQYQEQYDLH PISVPSLHVQ GELDTITEPA 

       190        200        210        220 
KVQGLYNSCT EDSRTLLMHS GGHFVPNSRG FVRKVAQWLQ QLT 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast."
Baxter S.M., Rosenblum J.S., Knutson S., Nelson M.R., Montimurro J.S., Di Gennaro J.A., Speir J.A., Burbaum J.J., Fetrow J.S.
Mol. Cell. Proteomics 3:209-225(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49939 Genomic DNA. Translation: CAA90193.1.
BK006946 Genomic DNA. Translation: DAA10121.1.
PIRS57590.
RefSeqNP_013949.1. NM_001182729.1.

3D structure databases

ProteinModelPortalQ05015.
SMRQ05015. Positions 5-217.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35400. 5 interactions.
DIPDIP-5637N.
MINTMINT-552116.
STRING4932.YMR222C.

Proteomic databases

MaxQBQ05015.
PaxDbQ05015.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR222C; YMR222C; YMR222C.
GeneID855262.
KEGGsce:YMR222C.

Organism-specific databases

CYGDYMR222c.
SGDS000004835. FSH2.

Phylogenomic databases

eggNOGNOG302067.
GeneTreeENSGT00730000113940.
HOGENOMHOG000194266.
OMAREDANGW.
OrthoDBEOG7J1894.

Enzyme and pathway databases

BioCycYEAST:G3O-32903-MONOMER.

Gene expression databases

GenevestigatorQ05015.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR005645. Serine_hydrolase_FSH.
[Graphical view]
PfamPF03959. FSH1. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

NextBio978858.

Entry information

Entry nameFSH2_YEAST
AccessionPrimary (citable) accession number: Q05015
Secondary accession number(s): D6W047
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families