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Q05015

- FSH2_YEAST

UniProt

Q05015 - FSH2_YEAST

Protein

Family of serine hydrolases 2

Gene

FSH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Serine hydrolase of unknown specificity.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei110 – 1101Charge relay systemBy similarity
    Active sitei174 – 1741Charge relay systemBy similarity
    Active sitei203 – 2031Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32903-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Family of serine hydrolases 2 (EC:3.1.-.-)
    Gene namesi
    Name:FSH2
    Ordered Locus Names:YMR222C
    ORF Names:YM9959.04C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR222c.
    SGDiS000004835. FSH2.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Family of serine hydrolases 2PRO_0000212581Add
    BLAST

    Proteomic databases

    MaxQBiQ05015.
    PaxDbiQ05015.

    Expressioni

    Gene expression databases

    GenevestigatoriQ05015.

    Interactioni

    Protein-protein interaction databases

    BioGridi35400. 5 interactions.
    DIPiDIP-5637N.
    MINTiMINT-552116.
    STRINGi4932.YMR222C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05015.
    SMRiQ05015. Positions 5-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase 3 family.Curated

    Phylogenomic databases

    eggNOGiNOG302067.
    GeneTreeiENSGT00730000113940.
    HOGENOMiHOG000194266.
    OMAiREDANGW.
    OrthoDBiEOG7J1894.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR005645. Serine_hydrolase_FSH.
    [Graphical view]
    PfamiPF03959. FSH1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q05015-1 [UniParc]FASTAAdd to Basket

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    MTKNVLMLHG LAQSGDYFAS KTKGFRAEME KLGYKLYYPT APNEFPPADV    50
    PDFLGEVIAD APGDGENTGV LAWLENDPST GGYFIPQTTI DYLHNYVLEN 100
    GPFAGIVGFS QGAGVAGYLA TDFNGLLGLT TEEQPPLEFF MAVSGFRFQP 150
    QQYQEQYDLH PISVPSLHVQ GELDTITEPA KVQGLYNSCT EDSRTLLMHS 200
    GGHFVPNSRG FVRKVAQWLQ QLT 223
    Length:223
    Mass (Da):24,534
    Last modified:November 1, 1997 - v1
    Checksum:iF7BE3BFCED4EC5B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49939 Genomic DNA. Translation: CAA90193.1.
    BK006946 Genomic DNA. Translation: DAA10121.1.
    PIRiS57590.
    RefSeqiNP_013949.1. NM_001182729.1.

    Genome annotation databases

    EnsemblFungiiYMR222C; YMR222C; YMR222C.
    GeneIDi855262.
    KEGGisce:YMR222C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49939 Genomic DNA. Translation: CAA90193.1 .
    BK006946 Genomic DNA. Translation: DAA10121.1 .
    PIRi S57590.
    RefSeqi NP_013949.1. NM_001182729.1.

    3D structure databases

    ProteinModelPortali Q05015.
    SMRi Q05015. Positions 5-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35400. 5 interactions.
    DIPi DIP-5637N.
    MINTi MINT-552116.
    STRINGi 4932.YMR222C.

    Proteomic databases

    MaxQBi Q05015.
    PaxDbi Q05015.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR222C ; YMR222C ; YMR222C .
    GeneIDi 855262.
    KEGGi sce:YMR222C.

    Organism-specific databases

    CYGDi YMR222c.
    SGDi S000004835. FSH2.

    Phylogenomic databases

    eggNOGi NOG302067.
    GeneTreei ENSGT00730000113940.
    HOGENOMi HOG000194266.
    OMAi REDANGW.
    OrthoDBi EOG7J1894.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32903-MONOMER.

    Miscellaneous databases

    NextBioi 978858.

    Gene expression databases

    Genevestigatori Q05015.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR005645. Serine_hydrolase_FSH.
    [Graphical view ]
    Pfami PF03959. FSH1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast."
      Baxter S.M., Rosenblum J.S., Knutson S., Nelson M.R., Montimurro J.S., Di Gennaro J.A., Speir J.A., Burbaum J.J., Fetrow J.S.
      Mol. Cell. Proteomics 3:209-225(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFSH2_YEAST
    AccessioniPrimary (citable) accession number: Q05015
    Secondary accession number(s): D6W047
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1070 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3