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Q05015

- FSH2_YEAST

UniProt

Q05015 - FSH2_YEAST

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Protein

Family of serine hydrolases 2

Gene

FSH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Serine hydrolase of unknown specificity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei110 – 1101Charge relay systemBy similarity
Active sitei174 – 1741Charge relay systemBy similarity
Active sitei203 – 2031Charge relay systemBy similarity

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BioCyciYEAST:G3O-32903-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Family of serine hydrolases 2 (EC:3.1.-.-)
Gene namesi
Name:FSH2
Ordered Locus Names:YMR222C
ORF Names:YM9959.04C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR222c.
SGDiS000004835. FSH2.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Family of serine hydrolases 2PRO_0000212581Add
BLAST

Proteomic databases

MaxQBiQ05015.
PaxDbiQ05015.

Expressioni

Gene expression databases

GenevestigatoriQ05015.

Interactioni

Protein-protein interaction databases

BioGridi35400. 6 interactions.
DIPiDIP-5637N.
MINTiMINT-552116.
STRINGi4932.YMR222C.

Structurei

3D structure databases

ProteinModelPortaliQ05015.
SMRiQ05015. Positions 5-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase 3 family.Curated

Phylogenomic databases

eggNOGiNOG302067.
GeneTreeiENSGT00730000113940.
HOGENOMiHOG000194266.
InParanoidiQ05015.
OMAiREDANGW.
OrthoDBiEOG7J1894.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR005645. Serine_hydrolase_FSH.
[Graphical view]
PfamiPF03959. FSH1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05015-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKNVLMLHG LAQSGDYFAS KTKGFRAEME KLGYKLYYPT APNEFPPADV
60 70 80 90 100
PDFLGEVIAD APGDGENTGV LAWLENDPST GGYFIPQTTI DYLHNYVLEN
110 120 130 140 150
GPFAGIVGFS QGAGVAGYLA TDFNGLLGLT TEEQPPLEFF MAVSGFRFQP
160 170 180 190 200
QQYQEQYDLH PISVPSLHVQ GELDTITEPA KVQGLYNSCT EDSRTLLMHS
210 220
GGHFVPNSRG FVRKVAQWLQ QLT
Length:223
Mass (Da):24,534
Last modified:November 1, 1997 - v1
Checksum:iF7BE3BFCED4EC5B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49939 Genomic DNA. Translation: CAA90193.1.
BK006946 Genomic DNA. Translation: DAA10121.1.
PIRiS57590.
RefSeqiNP_013949.1. NM_001182729.1.

Genome annotation databases

EnsemblFungiiYMR222C; YMR222C; YMR222C.
GeneIDi855262.
KEGGisce:YMR222C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49939 Genomic DNA. Translation: CAA90193.1 .
BK006946 Genomic DNA. Translation: DAA10121.1 .
PIRi S57590.
RefSeqi NP_013949.1. NM_001182729.1.

3D structure databases

ProteinModelPortali Q05015.
SMRi Q05015. Positions 5-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35400. 6 interactions.
DIPi DIP-5637N.
MINTi MINT-552116.
STRINGi 4932.YMR222C.

Proteomic databases

MaxQBi Q05015.
PaxDbi Q05015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR222C ; YMR222C ; YMR222C .
GeneIDi 855262.
KEGGi sce:YMR222C.

Organism-specific databases

CYGDi YMR222c.
SGDi S000004835. FSH2.

Phylogenomic databases

eggNOGi NOG302067.
GeneTreei ENSGT00730000113940.
HOGENOMi HOG000194266.
InParanoidi Q05015.
OMAi REDANGW.
OrthoDBi EOG7J1894.

Enzyme and pathway databases

BioCyci YEAST:G3O-32903-MONOMER.

Miscellaneous databases

NextBioi 978858.

Gene expression databases

Genevestigatori Q05015.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR005645. Serine_hydrolase_FSH.
[Graphical view ]
Pfami PF03959. FSH1. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast."
    Baxter S.M., Rosenblum J.S., Knutson S., Nelson M.R., Montimurro J.S., Di Gennaro J.A., Speir J.A., Burbaum J.J., Fetrow J.S.
    Mol. Cell. Proteomics 3:209-225(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFSH2_YEAST
AccessioniPrimary (citable) accession number: Q05015
Secondary accession number(s): D6W047
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1070 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3