Q05007 (ABDA_ARTSF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein abdominal-A homolog

Gene names

Name:

ABDA

Organism

Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)

Taxonomic identifier

6661 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Crustacea › Branchiopoda › Sarsostraca › Anostraca › Artemiidae › Artemia

Protein attributes

Sequence length	139 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for segmental identity of the second through eighth abdominal segments. Once a pattern of abdA expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments. The abdA product appears to repress expression of Ubx whenever they appear in the same cell, but abdA is repressed by AbdB only in the eight and ninth abdominal segments.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 139	›139	Homeobox protein abdominal-A homolog		PRO_0000200255
Regions
	DNA binding	6 – 65	60	Homeobox
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q05007 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 7DF831839E298E32	FASTA	139	16,311
	10 20 30 40 50 60 PNGCPRRRGR QTYTRYQTLE LEKEFHFNHY LTRRRRIEIA HALCLTERQI KIWFQNRRMK 70 80 90 100 110 120 LKKELRAVKE INEQARKDRE EQEHKIRSSS SDDGSIGKGV GIPLDASLLK SNDSQSVSLN 130 HLTHKSPDGM MDKTPKSII

References

[1]	"HOM/Hox genes of Artemia: implications for the origin of insect and crustacea body plans." Averof M., Akam M. Curr. Biol. 3:73-78(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70076 Genomic DNA. Translation: CAA49681.1.
PIR	S31810.
3D structure databases
ProteinModelPortal	Q05007.
SMR	Q05007. Positions 6-64.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR022132. Abdominal-A. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF12407. Abdominal-A. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABDA_ARTSF

Accession

Primary (citable) accession number: Q05007

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	March 6, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)