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Q04YC8 (THIM_LEPBL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:LBL_2553
OrganismLeptospira borgpetersenii serovar Hardjo-bovis (strain L550) [Complete proteome] [HAMAP]
Taxonomic identifier355276 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_1000021517

Sites

Binding site551Substrate; via amide nitrogen By similarity
Binding site1301ATP By similarity
Binding site1761ATP By similarity
Binding site2031Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04YC8 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: FB4EEF5732113255

FASTA26427,495
        10         20         30         40         50         60 
MPKHSALERA WPAKEIVEDL LELRKRSPLT HIMTNIVVTN WTANVLLAVG ASPAMVIAEE 

        70         80         90        100        110        120 
EAGEFVKIAN GLLINVGTIT SNDAKAMKIA ATVAHQTNTP WVLDPVAVGA LGFRTETTKK 

       130        140        150        160        170        180 
LLDLKPTVIR GNASEILTLA GIAGKGKGVD STVNSKDALP YAQELSGKTG AVVAVSGEVD 

       190        200        210        220        230        240 
YVTNGKETIE IYGGDPIMTK VTGVGCSLGA LIASFLGIQK DPLRASASAS AVFAIAGSRS 

       250        260 
AKKSNGPGSF AINFIDQLSQ LSIE 

« Hide

References

[1]"Genome reduction in Leptospira borgpetersenii reflects limited transmission potential."
Bulach D.M., Zuerner R.L., Wilson P., Seemann T., McGrath A., Cullen P.A., Davis J., Johnson M., Kuczek E., Alt D.P., Peterson-Burch B., Coppel R.L., Rood J.I., Davies J.K., Adler B.
Proc. Natl. Acad. Sci. U.S.A. 103:14560-14565(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: L550.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000348 Genomic DNA. Translation: ABJ79917.1.
RefSeqYP_798850.1. NC_008508.1.

3D structure databases

ProteinModelPortalQ04YC8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING355276.LBL_2553.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ79917; ABJ79917; LBL_2553.
GeneID4407884.
KEGGlbl:LBL_2553.
PATRIC22369672. VBILepBor75619_3284.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycLBOR355276:GHUQ-2527-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_LEPBL
AccessionPrimary (citable) accession number: Q04YC8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways