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Q04XB2

- TRMB_LEPBL

UniProt

Q04XB2 - TRMB_LEPBL

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, LBL_2969
Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481S-adenosyl-L-methionine By similarity
Binding sitei73 – 731S-adenosyl-L-methionine By similarity
Binding sitei100 – 1001S-adenosyl-L-methionine By similarity
Active sitei123 – 1231 By similarity
Binding sitei123 – 1231S-adenosyl-L-methionine By similarity
Binding sitei127 – 1271Substrate By similarity
Binding sitei159 – 1591Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciLBOR355276:GHUQ-2937-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    Name:trmB
    Ordered Locus Names:LBL_2969
    OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain L550)
    Taxonomic identifieri355276 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000000655: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000288170Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi355276.LBL_2969.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04XB2.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000040678.
    KOiK03439.
    OMAiAEWIASH.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04XB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQDLEQKLW SIASGIPFVS DYFLQASPAR KLKKENLFSK VFETYFLELG    50
    SGWGEVAIAM ALQRRNTGFV LMEKKFDRIR HTIREIEKHS LDNVKILCVN 100
    FNWFLADVFE ENLFSEILLN FPDPWPKKRH HKKRTINSKF IESLRVLLPE 150
    KGKFSFATDY GPYARKTIRL FRDSEIFKPE TMEFRLERKE IPVSHFERKK 200
    RKEGKRIYYI DQILIRK 217
    Length:217
    Mass (Da):26,000
    Last modified:November 14, 2006 - v1
    Checksum:iCE903272344ADD04
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000348 Genomic DNA. Translation: ABJ80283.1.
    RefSeqiYP_799216.1. NC_008508.1.

    Genome annotation databases

    EnsemblBacteriaiABJ80283; ABJ80283; LBL_2969.
    GeneIDi4406027.
    KEGGilbl:LBL_2969.
    PATRICi22370790. VBILepBor75619_3838.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000348 Genomic DNA. Translation: ABJ80283.1 .
    RefSeqi YP_799216.1. NC_008508.1.

    3D structure databases

    ProteinModelPortali Q04XB2.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 355276.LBL_2969.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ80283 ; ABJ80283 ; LBL_2969 .
    GeneIDi 4406027.
    KEGGi lbl:LBL_2969.
    PATRICi 22370790. VBILepBor75619_3838.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000040678.
    KOi K03439.
    OMAi AEWIASH.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci LBOR355276:GHUQ-2937-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: L550.

    Entry informationi

    Entry nameiTRMB_LEPBL
    AccessioniPrimary (citable) accession number: Q04XB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: November 14, 2006
    Last modified: June 11, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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