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Protein

dCTP deaminase

Gene

dcd

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:LBL_3016
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Taxonomic identifieri355276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001179781 – 173dCTP deaminaseAdd BLAST173

Interactioni

Protein-protein interaction databases

STRINGi355276.LBL_3016.

Structurei

3D structure databases

ProteinModelPortaliQ04X69.
SMRiQ04X69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107S9R. Bacteria.
COG0717. LUCA.
HOGENOMiHOG000228601.
KOiK01494.
OMAiKGDVGFC.
OrthoDBiPOG091H021I.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR033704. dUTPase_trimeric.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04X69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILTGKEIQK RIGKDIIITP YSEKQLNPNS YNLRLHEELL IYTELPLDMK
60 70 80 90 100
KPNLTKKQII PESGLLLKPG ILYLGRTLEF TETHHLVPML EGRSSIGRLG
110 120 130 140 150
MLVHVTAGFG DVGFKGFWTL EISVIQPLIV YPGVEVCQIF YHTLEGQITE
160 170
YTSGKYQANQ GIQPSMLYQD FEK
Length:173
Mass (Da):19,695
Last modified:November 14, 2006 - v1
Checksum:i5B8427DA0A80D4C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000348 Genomic DNA. Translation: ABJ80326.1.
RefSeqiWP_011671221.1. NC_008508.1.

Genome annotation databases

EnsemblBacteriaiABJ80326; ABJ80326; LBL_3016.
GeneIDi4405966.
KEGGilbl:LBL_3016.
PATRICi22370900. VBILepBor75619_3893.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000348 Genomic DNA. Translation: ABJ80326.1.
RefSeqiWP_011671221.1. NC_008508.1.

3D structure databases

ProteinModelPortaliQ04X69.
SMRiQ04X69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi355276.LBL_3016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ80326; ABJ80326; LBL_3016.
GeneIDi4405966.
KEGGilbl:LBL_3016.
PATRICi22370900. VBILepBor75619_3893.

Phylogenomic databases

eggNOGiENOG4107S9R. Bacteria.
COG0717. LUCA.
HOGENOMiHOG000228601.
KOiK01494.
OMAiKGDVGFC.
OrthoDBiPOG091H021I.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR033704. dUTPase_trimeric.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCD_LEPBL
AccessioniPrimary (citable) accession number: Q04X69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 14, 2006
Last modified: November 30, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.