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Q04X60

- DAPF_LEPBL

UniProt

Q04X60 - DAPF_LEPBL

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Protein
Diaminopimelate epimerase
Gene
dapF, LBL_3025
Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Substrate By similarity
Binding sitei47 – 471Substrate By similarity
Binding sitei65 – 651Substrate By similarity
Active sitei74 – 741Proton donor/acceptor By similarity
Binding sitei165 – 1651Substrate By similarity
Sitei167 – 1671Important for catalytic activity By similarity
Binding sitei198 – 1981Substrate By similarity
Sitei216 – 2161Important for catalytic activity By similarity
Active sitei225 – 2251Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciLBOR355276:GHUQ-2993-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:LBL_3025
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Taxonomic identifieri355276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000000655: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Diaminopimelate epimeraseUniRule annotation
PRO_1000011898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi74 ↔ 225UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi355276.LBL_3025.

Structurei

3D structure databases

ProteinModelPortaliQ04X60.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni11 – 122Substrate binding By similarity
Regioni74 – 763Substrate binding By similarity
Regioni216 – 2172Substrate binding By similarity
Regioni226 – 2272Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiLIVEPPY.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04X60-1 [UniParc]FASTAAdd to Basket

« Hide

MAALKFTKME GIGNDYIYID STQANIRLTP EQIQKISNRN FGIGSDGVIF    50
IRNSKQGDFM MDMYNSDGSS SEMCGNGIRC VAKYIYDHGL TNSKNPKIET 100
GAGVLEVDLK IGSGNKVDFV SVNMGKPILV PSKIPVNWKD EEAIIDQTFE 150
IAGKNLKFTA VSMGNPHCVI FVDDCDQFPV TGIGPLIERH PIFPKRINVE 200
FVTVRGKDHF YQRTWERGAG ETLACGTGAC AVTVAGNLTG KSGKEVKIDL 250
RGGTLRIQWQ ESGNVLMTGP AKEIFSGEIE V 281
Length:281
Mass (Da):30,736
Last modified:November 14, 2006 - v1
Checksum:i08CB09F2D186D4EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000348 Genomic DNA. Translation: ABJ80335.1.
RefSeqiYP_799268.1. NC_008508.1.

Genome annotation databases

EnsemblBacteriaiABJ80335; ABJ80335; LBL_3025.
GeneIDi4405975.
KEGGilbl:LBL_3025.
PATRICi22370920. VBILepBor75619_3903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000348 Genomic DNA. Translation: ABJ80335.1 .
RefSeqi YP_799268.1. NC_008508.1.

3D structure databases

ProteinModelPortali Q04X60.
ModBasei Search...

Protein-protein interaction databases

STRINGi 355276.LBL_3025.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ80335 ; ABJ80335 ; LBL_3025 .
GeneIDi 4405975.
KEGGi lbl:LBL_3025.
PATRICi 22370920. VBILepBor75619_3903.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi LIVEPPY.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci LBOR355276:GHUQ-2993-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L550.

Entry informationi

Entry nameiDAPF_LEPBL
AccessioniPrimary (citable) accession number: Q04X60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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