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Protein

Cobalt-precorrin-5B C(1)-methyltransferase

Gene

cbiD

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.UniRule annotation

Catalytic activityi

Cobalt-precorrin-5B + S-adenosyl-L-methionine = cobalt-precorrin-6A + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route).UniRule annotation
Proteins known to be involved in the 10 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Cobalt-precorrin-5B C(1)-methyltransferase (cbiD)
  7. no protein annotated in this organism
  8. no protein annotated in this organism
  9. no protein annotated in this organism
  10. no protein annotated in this organism
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route), the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCobalamin biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00148; UER00227

Names & Taxonomyi

Protein namesi
Recommended name:
Cobalt-precorrin-5B C(1)-methyltransferaseUniRule annotation (EC:2.1.1.195UniRule annotation)
Alternative name(s):
Cobalt-precorrin-6A synthaseUniRule annotation
Gene namesi
Name:cbiDUniRule annotation
Ordered Locus Names:LBL_4195
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Taxonomic identifieri355276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000468601 – 369Cobalt-precorrin-5B C(1)-methyltransferaseAdd BLAST369

Structurei

3D structure databases

ProteinModelPortaliQ04WN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CbiD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EE8 Bacteria
COG1903 LUCA
HOGENOMiHOG000009126
KOiK02188
OMAiGGIFHTH
OrthoDBiPOG091H02QJ

Family and domain databases

Gene3Di3.30.2110.10, 1 hit
HAMAPiMF_00787 CbiD, 1 hit
InterProiView protein in InterPro
IPR002748 CbiD
IPR036074 CbiD_sf
PANTHERiPTHR35863 PTHR35863, 1 hit
PfamiView protein in Pfam
PF01888 CbiD, 1 hit
PIRSFiPIRSF026782 CbiD, 1 hit
SUPFAMiSSF111342 SSF111342, 1 hit
TIGRFAMsiTIGR00312 cbiD, 1 hit

Sequencei

Sequence statusi: Complete.

Q04WN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKELREGF TTGACSAAAA KAATRLLLKG EPVLEIETTL PNDRQVLFPV
60 70 80 90 100
KRCQLEGEVA ICSVVKDAGD DPDCTHGAEL TARVRLTKES KIVLKGGDGV
110 120 130 140 150
ATVTKTGLGI EVGEPAINPI PRKNISEMIL EELKGSSFNG AEVEISVPGG
160 170 180 190 200
QEMAKKTMNK RLGLIGGISI IGTTGIVKPF STAAFKASVI QAIRMAREYE
210 220 230 240 250
VDTVILTTGG KSEKFAMNLF PNLKELSFIQ AGDFIGTGIK TSVKEFIRHV
260 270 280 290 300
IVVGMIGKLS KMADGVMMTH RGGSSVNTKM LSDIARSVGI PEPIAIDIQN
310 320 330 340 350
ANTARHALEI CKENGYEIIT TKICEIVARN CSKHAGTNMS ISCYMVDFDG
360
TLLGKFENFS QKSKLRKGI
Length:369
Mass (Da):39,525
Last modified:November 14, 2006 - v1
Checksum:i9EEF122441FFD3FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000349 Genomic DNA Translation: ABJ80510.1
RefSeqiWP_011671370.1, NC_008509.1

Genome annotation databases

EnsemblBacteriaiABJ80510; ABJ80510; LBL_4195
GeneIDi4409075
KEGGilbl:LBL_4195

Similar proteinsi

Entry informationi

Entry nameiCBID_LEPBL
AccessioniPrimary (citable) accession number: Q04WN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health