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Q04WI9

- Q04WI9_LEPBL

UniProt

Q04WI9 - Q04WI9_LEPBL

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Protein

Alanine racemase

Gene
alr, LBL_4246
Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain L550)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei134 – 1341Substrate By similarityUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciLBOR355276:GHUQ-3244-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:LBL_4246Imported
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain L550)Imported
Taxonomic identifieri355276 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000000655: Chromosome 2

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi355276.LBL_4246.

Structurei

3D structure databases

ProteinModelPortaliQ04WI9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiQQIPCVA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04WI9-1 [UniParc]FASTAAdd to Basket

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MKETASSWIE ISKRSLSNNL NSFRSILRPG STLTAILKSN AYGHGTDLMA    50
KLCIEEGVSH IGVNSIEEAQ SIRQIDPKIP ILIMGEIQNP EKRKEALSDP 100
NFWIIFSRPE TARILSSLNP APKLHLKIDT GMGRLGNHGE TLKYTLGELK 150
KNGITLDGIC THFASTEDVL EHKYSLMQIQ KFEKAVLLAE SLGYKNLIRH 200
MCASASTMLF SSAHYEMVRV GISLYGLWPS IQTRLSLNLN GNKNFQLSPI 250
LSWKTRIVHI QNHPADSYIG YGSTFQTSYP TKVAIVPIGY YEGLDRKLSS 300
NGDMLVLGKR ARIIGRICMN MTMLDVTHIS GADVGSVVTV IGQDGEELIT 350
ADDIADRTHT INYEITTRIS ESVCRIVVD 379
Length:379
Mass (Da):42,066
Last modified:November 14, 2006 - v1
Checksum:i4838C83698448241
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000349 Genomic DNA. Translation: ABJ80556.1.
RefSeqiYP_799489.1. NC_008509.1.

Genome annotation databases

EnsemblBacteriaiABJ80556; ABJ80556; LBL_4246.
GeneIDi4409200.
KEGGilbl:LBL_4246.
PATRICi22371569. VBILepBor75619_4227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000349 Genomic DNA. Translation: ABJ80556.1 .
RefSeqi YP_799489.1. NC_008509.1.

3D structure databases

ProteinModelPortali Q04WI9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355276.LBL_4246.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ80556 ; ABJ80556 ; LBL_4246 .
GeneIDi 4409200.
KEGGi lbl:LBL_4246.
PATRICi 22371569. VBILepBor75619_4227.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi QQIPCVA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci LBOR355276:GHUQ-3244-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: L550Imported.

Entry informationi

Entry nameiQ04WI9_LEPBL
AccessioniPrimary (citable) accession number: Q04WI9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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