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Q04W54

- TRMB_LEPBJ

UniProt

Q04W54 - TRMB_LEPBJ

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
trmB, LBJ_0122
Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481S-adenosyl-L-methionine By similarity
Binding sitei73 – 731S-adenosyl-L-methionine By similarity
Binding sitei100 – 1001S-adenosyl-L-methionine By similarity
Active sitei123 – 1231 By similarity
Binding sitei123 – 1231S-adenosyl-L-methionine By similarity
Binding sitei127 – 1271Substrate By similarity
Binding sitei159 – 1591Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciLBOR355277:GHYM-120-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:LBJ_0122
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Taxonomic identifieri355277 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000000656: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000288169Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi355277.LBJ_0122.

Structurei

3D structure databases

ProteinModelPortaliQ04W54.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000040678.
KOiK03439.
OMAiAEWIASH.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04W54-1 [UniParc]FASTAAdd to Basket

« Hide

MSQDLEQKLW SIASGIPFVS DYFLQASPAR KLKKENLFSK VFETYFLELG    50
SGWGEVAIAM ALQRRNTGFV LMEKKFDRIR HTIREIEKHS LDNVKILCVN 100
FNWFLADVFE ENLFSEILLN FPDPWPKKRH HKKRTINSKF IESLRVLLPE 150
KGKFSFATDY GPYARKTIRL FRDSEIFKPE TMEFRLERKE IPVSHFERKK 200
RKEGKRIYYI DQILIRK 217
Length:217
Mass (Da):26,000
Last modified:November 14, 2006 - v1
Checksum:iCE903272344ADD04
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000350 Genomic DNA. Translation: ABJ74866.1.
RefSeqiYP_799624.1. NC_008510.1.

Genome annotation databases

EnsemblBacteriaiABJ74866; ABJ74866; LBJ_0122.
GeneIDi4410771.
KEGGilbj:LBJ_0122.
PATRICi22354822. VBILepBor13265_0141.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000350 Genomic DNA. Translation: ABJ74866.1 .
RefSeqi YP_799624.1. NC_008510.1.

3D structure databases

ProteinModelPortali Q04W54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355277.LBJ_0122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ74866 ; ABJ74866 ; LBJ_0122 .
GeneIDi 4410771.
KEGGi lbj:LBJ_0122.
PATRICi 22354822. VBILepBor13265_0141.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000040678.
KOi K03439.
OMAi AEWIASH.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci LBOR355277:GHYM-120-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JB197.

Entry informationi

Entry nameiTRMB_LEPBJ
AccessioniPrimary (citable) accession number: Q04W54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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