Q04RU6 (UVRC_LEPBJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UvrABC system protein C
Short name=Protein UvrC

Alternative name(s):
Excinuclease ABC subunit C

Gene names

Name:	uvrC
Ordered Locus Names:	LBJ_1853

Organism

Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197) [Complete proteome] [HAMAP]

Taxonomic identifier

355277 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Leptospiraceae › Leptospira › Leptospira borgpetersenii › Leptospira borgpetersenii serovar Hardjo-bovis

Protein attributes

Sequence length	609 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203
Subunit structure	Interacts with UvrB in an incision complex By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the UvrC family. Contains 1 GIY-YIG domain. Contains 1 UVR domain.

Ontologies

Keywords
Biological process	DNA damage DNA excision DNA repair SOS response
Cellular component	Cytoplasm
Molecular function	Excision nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	SOS response Inferred from electronic annotation. Source: HAMAP nucleotide-excision repair Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell excinuclease repair complex Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: HAMAP excinuclease ABC activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 609	609	UvrABC system protein C HAMAP-Rule MF_00203		PRO_1000077803
Regions
	Domain	19 – 97	79	GIY-YIG
	Domain	208 – 243	36	UVR

Sequences

	Sequence		Length	Mass (Da)
	Q04RU6 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: A7F6FE524049C19A	FASTA	609	69,680
	10 20 30 40 50 60 MPEILNHILI LEKIKNLGIS PGCYLWKSRK GEVLYIGKAK NLDKRVRNYL KENHPDIKTR 70 80 90 100 110 120 ALQKEIFDLD WIATGTEKEA LILEATLIKK HNPRFNVRFK DDKKYPYICV SLSESFPMVY 130 140 150 160 170 180 ITRKLKDNGD RYFGPYSDVK STRETLDIIL RIFPVRKTRQ VLPLPKPRRP CLNFDMGRCL 190 200 210 220 230 240 GPCQGNIPVE DYKIVIDQVI QFLEGKKESL VGDLSIKMSA SSNRMDFEKA ARYRDMLQRI 250 260 270 280 290 300 QNFREKQTVV SAEGGDEDVI GFARKKDEGQ VILLEVRGGR LETKKSFPIQ GVLDAEDSEI 310 320 330 340 350 360 LGAFFRDYYL NAALVPPLIF VPADIQEETA AVMDVLQEKT GFRPKLKSPR GGDKRSLLKI 370 380 390 400 410 420 AEKNAELGLT ERLLATHYRD QTASLKEIQE MFSLEHPPHI IECYDISHFQ GSEPVASGVM 430 440 450 460 470 480 FVEGKPFKQG YRKYNIRGYK GINDPGMIHE VISRRLQRIA NEESVFPDLI VIDGGPTQLA 490 500 510 520 530 540 KACEAAMEAG AERIPMIGLA KKREEIYFPG DNEPFIFDMN SSGMKLLRHL RDEAHRFGVS 550 560 570 580 590 600 HHRSRRNKET MRSLIQNVPD IGLKRSKLLL RHFSGEKKIE DATKEELLAV PGIGENLAEK ILKRIRKKE

References

[1]

"Genome reduction in Leptospira borgpetersenii reflects limited transmission potential." Bulach D.M., Zuerner R.L., Wilson P., Seemann T., McGrath A., Cullen P.A., Davis J., Johnson M., Kuczek E., Alt D.P., Peterson-Burch B., Coppel R.L., Rood J.I., Davies J.K., Adler B. Proc. Natl. Acad. Sci. U.S.A. 103:14560-14565(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JB197.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000350 Genomic DNA. Translation: ABJ76374.1.
RefSeq	YP_801132.1. NC_008510.1.
3D structure databases
ProteinModelPortal	Q04RU6.
ModBase	Search...
Protein-protein interaction databases
STRING	355277.LBJ_1853.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABJ76374; ABJ76374; LBJ_1853.
GeneID	4409998.
KEGG	lbj:LBJ_1853.
PATRIC	22359348. VBILepBor13265_2381.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0322.
HOGENOM	HOG000279960.
KO	K03703.
OMA	QKLFPIR.
ProtClustDB	PRK00558.
Enzyme and pathway databases
BioCyc	LBOR355277:GHYM-2110-MONOMER.
Family and domain databases
Gene3D	3.40.1440.10. 1 hit. 4.10.860.10. 1 hit.
HAMAP	MF_00203. UvrC.
InterPro	IPR027299. GIY-YIG_dom. IPR000305. GIY-YIG_SF. IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif. IPR010994. RuvA_2-like. IPR001943. UVR_dom. IPR004791. UvrC. IPR001162. UvrC_homol_region. [Graphical view]
Pfam	PF01541. GIY-YIG. 1 hit. PF02151. UVR. 1 hit. PF08459. UvrC_HhH_N. 1 hit. [Graphical view]
SMART	SM00465. GIYc. 1 hit. SM00278. HhH1. 2 hits. [Graphical view]
SUPFAM	SSF47781. RuvA_2_like. 1 hit. SSF46600. UvrB_C. 1 hit. SSF82771. UvrC_N. 1 hit.
TIGRFAMs	TIGR00194. uvrC. 1 hit.
PROSITE	PS50164. GIY_YIG. 1 hit. PS50151. UVR. 1 hit. PS50165. UVRC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UVRC_LEPBJ

Accession

Primary (citable) accession number: Q04RU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 14, 2006
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program