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Q04RU6 (UVRC_LEPBJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:LBJ_1853
OrganismLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197) [Complete proteome] [HAMAP]
Taxonomic identifier355277 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length609 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Contains 1 UVR domain.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 609609UvrABC system protein C HAMAP-Rule MF_00203
PRO_1000077803

Regions

Domain19 – 9779GIY-YIG
Domain208 – 24336UVR

Sequences

Sequence LengthMass (Da)Tools
Q04RU6 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: A7F6FE524049C19A

FASTA60969,680
        10         20         30         40         50         60 
MPEILNHILI LEKIKNLGIS PGCYLWKSRK GEVLYIGKAK NLDKRVRNYL KENHPDIKTR 

        70         80         90        100        110        120 
ALQKEIFDLD WIATGTEKEA LILEATLIKK HNPRFNVRFK DDKKYPYICV SLSESFPMVY 

       130        140        150        160        170        180 
ITRKLKDNGD RYFGPYSDVK STRETLDIIL RIFPVRKTRQ VLPLPKPRRP CLNFDMGRCL 

       190        200        210        220        230        240 
GPCQGNIPVE DYKIVIDQVI QFLEGKKESL VGDLSIKMSA SSNRMDFEKA ARYRDMLQRI 

       250        260        270        280        290        300 
QNFREKQTVV SAEGGDEDVI GFARKKDEGQ VILLEVRGGR LETKKSFPIQ GVLDAEDSEI 

       310        320        330        340        350        360 
LGAFFRDYYL NAALVPPLIF VPADIQEETA AVMDVLQEKT GFRPKLKSPR GGDKRSLLKI 

       370        380        390        400        410        420 
AEKNAELGLT ERLLATHYRD QTASLKEIQE MFSLEHPPHI IECYDISHFQ GSEPVASGVM 

       430        440        450        460        470        480 
FVEGKPFKQG YRKYNIRGYK GINDPGMIHE VISRRLQRIA NEESVFPDLI VIDGGPTQLA 

       490        500        510        520        530        540 
KACEAAMEAG AERIPMIGLA KKREEIYFPG DNEPFIFDMN SSGMKLLRHL RDEAHRFGVS 

       550        560        570        580        590        600 
HHRSRRNKET MRSLIQNVPD IGLKRSKLLL RHFSGEKKIE DATKEELLAV PGIGENLAEK 


ILKRIRKKE 

« Hide

References

[1]"Genome reduction in Leptospira borgpetersenii reflects limited transmission potential."
Bulach D.M., Zuerner R.L., Wilson P., Seemann T., McGrath A., Cullen P.A., Davis J., Johnson M., Kuczek E., Alt D.P., Peterson-Burch B., Coppel R.L., Rood J.I., Davies J.K., Adler B.
Proc. Natl. Acad. Sci. U.S.A. 103:14560-14565(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JB197.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000350 Genomic DNA. Translation: ABJ76374.1.
RefSeqYP_801132.1. NC_008510.1.

3D structure databases

ProteinModelPortalQ04RU6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING355277.LBJ_1853.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ76374; ABJ76374; LBJ_1853.
GeneID4409998.
KEGGlbj:LBJ_1853.
PATRIC22359348. VBILepBor13265_2381.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279960.
KOK03703.
OMAQKLFPIR.
OrthoDBEOG6K13R9.
ProtClustDBPRK00558.

Enzyme and pathway databases

BioCycLBOR355277:GHYM-1829-MONOMER.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_LEPBJ
AccessionPrimary (citable) accession number: Q04RU6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families