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Protein

Malate dehydrogenase

Gene

mdh

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Binding sitei98SubstrateUniRule annotation1
Binding sitei105NADUniRule annotation1
Binding sitei112NADUniRule annotation1
Binding sitei131SubstrateUniRule annotation1
Binding sitei162SubstrateUniRule annotation1
Active sitei187Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 17NADUniRule annotation7
Nucleotide bindingi129 – 131NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:LBJ_1874
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Taxonomic identifieri355277 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000000656 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002943881 – 326Malate dehydrogenaseAdd BLAST326

Proteomic databases

PRIDEiQ04RS5

Structurei

3D structure databases

ProteinModelPortaliQ04RS5
SMRiQ04RS5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000220953
KOiK00024
OMAiRPRTKGM
OrthoDBiPOG091H03R4

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01517 Malate_dehydrog_2, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23382 PTHR23382, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01759 MalateDH-SF1, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q04RS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTVKVAVT GAAGQIGYSL LFRIASGQMF GTDTAVEIQM LELEAAIPAA
60 70 80 90 100
KGVIMELEDC AFPLLQKVTV SSDLDIAFKD INWALLVGSV PRKAGMERGD
110 120 130 140 150
LLKINGGIFI NQGKAIEKNA ASDVRVLVVG NPCNTNCLIA MNNAKGIPSD
160 170 180 190 200
RWFAMTKLDE NRAKSQLASK AGVPVKEVTH LGIWGNHSST QYPDFYNAKI
210 220 230 240 250
SGKPVTDVIS DHEWLKGDFI KNVQQRGAEI IKARGASSAA SAANGVVDTV
260 270 280 290 300
RAIITPTASG DAFSAAIASD GSYGTEKGLI FGFPLKSDGK KVGIVQGLPF
310 320
NDFAKEKFKT THDELISERN EVKDML
Length:326
Mass (Da):34,791
Last modified:November 14, 2006 - v1
Checksum:i0344199F71C9D008
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000350 Genomic DNA Translation: ABJ76395.1
RefSeqiWP_011670105.1, NC_008510.1

Genome annotation databases

EnsemblBacteriaiABJ76395; ABJ76395; LBJ_1874
GeneIDi4407274
KEGGilbj:LBJ_1874

Similar proteinsi

Entry informationi

Entry nameiMDH_LEPBJ
AccessioniPrimary (citable) accession number: Q04RS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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