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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei639ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LBJ_2541
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Taxonomic identifieri355277 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000000656 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093641 – 864Leucine--tRNA ligaseAdd BLAST864

Proteomic databases

PRIDEiQ04Q48

Structurei

3D structure databases

ProteinModelPortaliQ04Q48
SMRiQ04Q48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi636 – 640"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 3 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q04Q48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQYPFQEVES FWQKFWEENK SFQTNIRSSK PKFYCLDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LSRFKRMKGF EVLHPMGWDA FGLPAERYAM QTGIHPAITT
110 120 130 140 150
KNNIDNFRRQ IQMIGLSYDW SRELSTTDPD YYKFTQWIFI QLYQSWFNPE
160 170 180 190 200
LKKAESIETL IQRFSNKGSA DLDYKPFSAQ EWKQFSLVEK EKILSDFRLV
210 220 230 240 250
YQAEIPVNWC EALGTVLANE EVEEWIDKGY EVVRKPMRQY MMRITAYADR
260 270 280 290 300
LLEDLKLVQW PSSTLEMQKN WIGKSEGLEI TFPFKKPLKS GSDGIRIFTT
310 320 330 340 350
RPDTIFGVTY MVVAPEHPIV SEITTPEQKQ KVEEYQKVSS LKSDLDRMEL
360 370 380 390 400
TKEKTGVFTG SFVLNPANPS KEIPIWISDY VLYGYGTGAI MAVPAHDQRD
410 420 430 440 450
YEFAKTFGLE ILPVIEGEIT DVAFDSKTSI CIHSSSSEIS IDGLDYSSAS
460 470 480 490 500
SKIISWAESK RIGKKKTQFK LRDWLFARQR YWGEPIPLVH YPSGITKPIP
510 520 530 540 550
ESELPLELPP NLEEFKPSGT GESPLALAKE WLQYKDPETG EIGTRETNTM
560 570 580 590 600
PQWAGSCWYY LRYIDPKNGK LFCDPDLEKK WMPVDLYVGG AEHAVLHLLY
610 620 630 640 650
SRFWHKFLYD IGVVSTQEPF AKLIHQGLIL GEDKRKMSKS LGNVINPDDV
660 670 680 690 700
IRKYGADSLR LFEMFMGPLE MVKPWSTRGV EGVFRFLNRV WRLFHTGEGE
710 720 730 740 750
SFRLDEIEPT TEELKILHKT IQKVGEDIPN FSFNTAISQL MIFVNEFTPS
760 770 780 790 800
DRRPKEVLET FILLLAPFAP HIAEELWKRS GNNKSLSTEK FPEADPQYLV
810 820 830 840 850
ESEILIVVQV NGKLRDEFKA PKDVSEADAI SIAKNLDKIK GILDGKTIRK
860
EIYVPGKLIN LVIG
Length:864
Mass (Da):99,488
Last modified:November 14, 2006 - v1
Checksum:i15A6F0DFD8404D54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000350 Genomic DNA Translation: ABJ76972.1
RefSeqiWP_011669510.1, NC_008510.1

Genome annotation databases

EnsemblBacteriaiABJ76972; ABJ76972; LBJ_2541
GeneIDi4408952
KEGGilbj:LBJ_2541

Similar proteinsi

Entry informationi

Entry nameiSYL_LEPBJ
AccessioniPrimary (citable) accession number: Q04Q48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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