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Q04Q48

- SYL_LEPBJ

UniProt

Q04Q48 - SYL_LEPBJ

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei639 – 6391ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBOR355277:GHYM-2510-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LBJ_2541
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Taxonomic identifieri355277 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000000656: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 864864Leucine--tRNA ligasePRO_1000009364Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi355277.LBJ_2541.

Structurei

3D structure databases

ProteinModelPortaliQ04Q48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi636 – 6405"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04Q48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQYPFQEVES FWQKFWEENK SFQTNIRSSK PKFYCLDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LSRFKRMKGF EVLHPMGWDA FGLPAERYAM QTGIHPAITT
110 120 130 140 150
KNNIDNFRRQ IQMIGLSYDW SRELSTTDPD YYKFTQWIFI QLYQSWFNPE
160 170 180 190 200
LKKAESIETL IQRFSNKGSA DLDYKPFSAQ EWKQFSLVEK EKILSDFRLV
210 220 230 240 250
YQAEIPVNWC EALGTVLANE EVEEWIDKGY EVVRKPMRQY MMRITAYADR
260 270 280 290 300
LLEDLKLVQW PSSTLEMQKN WIGKSEGLEI TFPFKKPLKS GSDGIRIFTT
310 320 330 340 350
RPDTIFGVTY MVVAPEHPIV SEITTPEQKQ KVEEYQKVSS LKSDLDRMEL
360 370 380 390 400
TKEKTGVFTG SFVLNPANPS KEIPIWISDY VLYGYGTGAI MAVPAHDQRD
410 420 430 440 450
YEFAKTFGLE ILPVIEGEIT DVAFDSKTSI CIHSSSSEIS IDGLDYSSAS
460 470 480 490 500
SKIISWAESK RIGKKKTQFK LRDWLFARQR YWGEPIPLVH YPSGITKPIP
510 520 530 540 550
ESELPLELPP NLEEFKPSGT GESPLALAKE WLQYKDPETG EIGTRETNTM
560 570 580 590 600
PQWAGSCWYY LRYIDPKNGK LFCDPDLEKK WMPVDLYVGG AEHAVLHLLY
610 620 630 640 650
SRFWHKFLYD IGVVSTQEPF AKLIHQGLIL GEDKRKMSKS LGNVINPDDV
660 670 680 690 700
IRKYGADSLR LFEMFMGPLE MVKPWSTRGV EGVFRFLNRV WRLFHTGEGE
710 720 730 740 750
SFRLDEIEPT TEELKILHKT IQKVGEDIPN FSFNTAISQL MIFVNEFTPS
760 770 780 790 800
DRRPKEVLET FILLLAPFAP HIAEELWKRS GNNKSLSTEK FPEADPQYLV
810 820 830 840 850
ESEILIVVQV NGKLRDEFKA PKDVSEADAI SIAKNLDKIK GILDGKTIRK
860
EIYVPGKLIN LVIG
Length:864
Mass (Da):99,488
Last modified:November 14, 2006 - v1
Checksum:i15A6F0DFD8404D54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000350 Genomic DNA. Translation: ABJ76972.1.
RefSeqiYP_801730.1. NC_008510.1.

Genome annotation databases

EnsemblBacteriaiABJ76972; ABJ76972; LBJ_2541.
GeneIDi4411815.
KEGGilbj:LBJ_2541.
PATRICi22361196. VBILepBor13265_3291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000350 Genomic DNA. Translation: ABJ76972.1 .
RefSeqi YP_801730.1. NC_008510.1.

3D structure databases

ProteinModelPortali Q04Q48.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355277.LBJ_2541.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ76972 ; ABJ76972 ; LBJ_2541 .
GeneIDi 4411815.
KEGGi lbj:LBJ_2541.
PATRICi 22361196. VBILepBor13265_3291.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LBOR355277:GHYM-2510-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JB197.

Entry informationi

Entry nameiSYL_LEPBJ
AccessioniPrimary (citable) accession number: Q04Q48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3