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Q04PM7

- GCSP_LEPBJ

UniProt

Q04PM7 - GCSP_LEPBJ

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciLBOR355277:GHYM-2697-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:LBJ_2732
    OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
    Taxonomic identifieri355277 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000000656: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 964964Glycine dehydrogenase (decarboxylating)PRO_1000045587Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei713 – 7131N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi355277.LBJ_2732.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04PM7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04PM7-1 [UniParc]FASTAAdd to Basket

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    MNSTLQNRNR TNLERVSTDP LDTFPRRHIG PDSQQVDKML KSLGLSSLEE    50
    LVDKAVPAGI RLKKEPDLPK ASTEHKILQD LKNIASQNQI FRSYIGAGYN 100
    ACIIPGVIQR NILENPGWYT AYTPYQAEIS QGRLEALLNF QTMIIDLTGL 150
    EISNASLLDE GTAAAEAMFL AYSIRKNEIA KKFFVSELCH PQTIDVVVTR 200
    ANPLGIEIVI GNHESVELNE DFFGVLLQYP ATDGKIIDYT SFIQRAHNVG 250
    AISTVAADLL ALTLLKSPGE MGADIAVGSS QRFGLPLGFG GPHAGYFATK 300
    DEFKRSMPGR LIGVSKDSQG NPGLRLSLQT REQHIRRDKA TSNICTAQVL 350
    LAVISSMYAV YHGPEGLKDI ATRIHKFTSI LADALKSSGF TISNDTFFDT 400
    ITIQAGAKAK DILNRARSER INLREYKDGR IGIALDETVN SDDIKDLFKI 450
    FEVKNTDIEK LFSNSGNISD SFKRSTSYLT HPVFQSFHTE TKMLRYIRKL 500
    ESRDLSLTTS MIPLGSCTMK LNATTEMYPV TWPEFGAIHP FAPSEQTKGY 550
    KIIFEQLEKW LCEITGFAGV SLQPNAGSQG EYAGLLAIRR YHESRKETHR 600
    NVCLIPISAH GTNPASAAMA GFKVVVVSCD QNGNVDLEDL KIKAEEHKND 650
    LAALMITYPS THGVFEESVK EICQIVHSRG GQVYMDGANM NAQVGLTSPG 700
    EIGADVCHLN LHKTFCIPHG GGGPGVGPIG VAKHLVPFLP GHVLVDNTTG 750
    NEHGAVSAAP WGSASIVLIS WIYIALMGSE GLTNATRISI LNANYIAKRL 800
    EKAYPVLYKG KNGFVAHECI LDVRPFKKSA EIEVEDVAKR LIDYGFHAPT 850
    MSFPVPGTLM IEPTESESLE ELDRFCEAML LIHQEILDVQ NGTLDKIDNP 900
    LKNSPHTAAM TTSDRWDHLY PKERAAYPAP WSRDHKFWPF VGRVDNVYGD 950
    RNLVCSCLPV ESYQ 964
    Length:964
    Mass (Da):106,287
    Last modified:November 14, 2006 - v1
    Checksum:i04E09A3DD637E767
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000350 Genomic DNA. Translation: ABJ77143.1.
    RefSeqiYP_801901.1. NC_008510.1.

    Genome annotation databases

    EnsemblBacteriaiABJ77143; ABJ77143; LBJ_2732.
    GeneIDi4410896.
    KEGGilbj:LBJ_2732.
    PATRICi22361662. VBILepBor13265_3518.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000350 Genomic DNA. Translation: ABJ77143.1 .
    RefSeqi YP_801901.1. NC_008510.1.

    3D structure databases

    ProteinModelPortali Q04PM7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 355277.LBJ_2732.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ77143 ; ABJ77143 ; LBJ_2732 .
    GeneIDi 4410896.
    KEGGi lbj:LBJ_2732.
    PATRICi 22361662. VBILepBor13265_3518.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci LBOR355277:GHYM-2697-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JB197.

    Entry informationi

    Entry nameiGCSP_LEPBJ
    AccessioniPrimary (citable) accession number: Q04PM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3