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Q04PM7

- GCSP_LEPBJ

UniProt

Q04PM7 - GCSP_LEPBJ

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, LBJ_2732
Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLBOR355277:GHYM-2697-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:LBJ_2732
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Taxonomic identifieri355277 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000000656: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000045587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei713 – 7131N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi355277.LBJ_2732.

Structurei

3D structure databases

ProteinModelPortaliQ04PM7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04PM7-1 [UniParc]FASTAAdd to Basket

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MNSTLQNRNR TNLERVSTDP LDTFPRRHIG PDSQQVDKML KSLGLSSLEE    50
LVDKAVPAGI RLKKEPDLPK ASTEHKILQD LKNIASQNQI FRSYIGAGYN 100
ACIIPGVIQR NILENPGWYT AYTPYQAEIS QGRLEALLNF QTMIIDLTGL 150
EISNASLLDE GTAAAEAMFL AYSIRKNEIA KKFFVSELCH PQTIDVVVTR 200
ANPLGIEIVI GNHESVELNE DFFGVLLQYP ATDGKIIDYT SFIQRAHNVG 250
AISTVAADLL ALTLLKSPGE MGADIAVGSS QRFGLPLGFG GPHAGYFATK 300
DEFKRSMPGR LIGVSKDSQG NPGLRLSLQT REQHIRRDKA TSNICTAQVL 350
LAVISSMYAV YHGPEGLKDI ATRIHKFTSI LADALKSSGF TISNDTFFDT 400
ITIQAGAKAK DILNRARSER INLREYKDGR IGIALDETVN SDDIKDLFKI 450
FEVKNTDIEK LFSNSGNISD SFKRSTSYLT HPVFQSFHTE TKMLRYIRKL 500
ESRDLSLTTS MIPLGSCTMK LNATTEMYPV TWPEFGAIHP FAPSEQTKGY 550
KIIFEQLEKW LCEITGFAGV SLQPNAGSQG EYAGLLAIRR YHESRKETHR 600
NVCLIPISAH GTNPASAAMA GFKVVVVSCD QNGNVDLEDL KIKAEEHKND 650
LAALMITYPS THGVFEESVK EICQIVHSRG GQVYMDGANM NAQVGLTSPG 700
EIGADVCHLN LHKTFCIPHG GGGPGVGPIG VAKHLVPFLP GHVLVDNTTG 750
NEHGAVSAAP WGSASIVLIS WIYIALMGSE GLTNATRISI LNANYIAKRL 800
EKAYPVLYKG KNGFVAHECI LDVRPFKKSA EIEVEDVAKR LIDYGFHAPT 850
MSFPVPGTLM IEPTESESLE ELDRFCEAML LIHQEILDVQ NGTLDKIDNP 900
LKNSPHTAAM TTSDRWDHLY PKERAAYPAP WSRDHKFWPF VGRVDNVYGD 950
RNLVCSCLPV ESYQ 964
Length:964
Mass (Da):106,287
Last modified:November 14, 2006 - v1
Checksum:i04E09A3DD637E767
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000350 Genomic DNA. Translation: ABJ77143.1.
RefSeqiYP_801901.1. NC_008510.1.

Genome annotation databases

EnsemblBacteriaiABJ77143; ABJ77143; LBJ_2732.
GeneIDi4410896.
KEGGilbj:LBJ_2732.
PATRICi22361662. VBILepBor13265_3518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000350 Genomic DNA. Translation: ABJ77143.1 .
RefSeqi YP_801901.1. NC_008510.1.

3D structure databases

ProteinModelPortali Q04PM7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355277.LBJ_2732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ77143 ; ABJ77143 ; LBJ_2732 .
GeneIDi 4410896.
KEGGi lbj:LBJ_2732.
PATRICi 22361662. VBILepBor13265_3518.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci LBOR355277:GHYM-2697-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JB197.

Entry informationi

Entry nameiGCSP_LEPBJ
AccessioniPrimary (citable) accession number: Q04PM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi