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Q04PM7

- GCSP_LEPBJ

UniProt

Q04PM7 - GCSP_LEPBJ

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLBOR355277:GHYM-2697-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:LBJ_2732
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Taxonomic identifieri355277 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000000656: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 964964Glycine dehydrogenase (decarboxylating)PRO_1000045587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei713 – 7131N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi355277.LBJ_2732.

Structurei

3D structure databases

ProteinModelPortaliQ04PM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04PM7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSTLQNRNR TNLERVSTDP LDTFPRRHIG PDSQQVDKML KSLGLSSLEE
60 70 80 90 100
LVDKAVPAGI RLKKEPDLPK ASTEHKILQD LKNIASQNQI FRSYIGAGYN
110 120 130 140 150
ACIIPGVIQR NILENPGWYT AYTPYQAEIS QGRLEALLNF QTMIIDLTGL
160 170 180 190 200
EISNASLLDE GTAAAEAMFL AYSIRKNEIA KKFFVSELCH PQTIDVVVTR
210 220 230 240 250
ANPLGIEIVI GNHESVELNE DFFGVLLQYP ATDGKIIDYT SFIQRAHNVG
260 270 280 290 300
AISTVAADLL ALTLLKSPGE MGADIAVGSS QRFGLPLGFG GPHAGYFATK
310 320 330 340 350
DEFKRSMPGR LIGVSKDSQG NPGLRLSLQT REQHIRRDKA TSNICTAQVL
360 370 380 390 400
LAVISSMYAV YHGPEGLKDI ATRIHKFTSI LADALKSSGF TISNDTFFDT
410 420 430 440 450
ITIQAGAKAK DILNRARSER INLREYKDGR IGIALDETVN SDDIKDLFKI
460 470 480 490 500
FEVKNTDIEK LFSNSGNISD SFKRSTSYLT HPVFQSFHTE TKMLRYIRKL
510 520 530 540 550
ESRDLSLTTS MIPLGSCTMK LNATTEMYPV TWPEFGAIHP FAPSEQTKGY
560 570 580 590 600
KIIFEQLEKW LCEITGFAGV SLQPNAGSQG EYAGLLAIRR YHESRKETHR
610 620 630 640 650
NVCLIPISAH GTNPASAAMA GFKVVVVSCD QNGNVDLEDL KIKAEEHKND
660 670 680 690 700
LAALMITYPS THGVFEESVK EICQIVHSRG GQVYMDGANM NAQVGLTSPG
710 720 730 740 750
EIGADVCHLN LHKTFCIPHG GGGPGVGPIG VAKHLVPFLP GHVLVDNTTG
760 770 780 790 800
NEHGAVSAAP WGSASIVLIS WIYIALMGSE GLTNATRISI LNANYIAKRL
810 820 830 840 850
EKAYPVLYKG KNGFVAHECI LDVRPFKKSA EIEVEDVAKR LIDYGFHAPT
860 870 880 890 900
MSFPVPGTLM IEPTESESLE ELDRFCEAML LIHQEILDVQ NGTLDKIDNP
910 920 930 940 950
LKNSPHTAAM TTSDRWDHLY PKERAAYPAP WSRDHKFWPF VGRVDNVYGD
960
RNLVCSCLPV ESYQ
Length:964
Mass (Da):106,287
Last modified:November 14, 2006 - v1
Checksum:i04E09A3DD637E767
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000350 Genomic DNA. Translation: ABJ77143.1.
RefSeqiYP_801901.1. NC_008510.1.

Genome annotation databases

EnsemblBacteriaiABJ77143; ABJ77143; LBJ_2732.
GeneIDi4410896.
KEGGilbj:LBJ_2732.
PATRICi22361662. VBILepBor13265_3518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000350 Genomic DNA. Translation: ABJ77143.1 .
RefSeqi YP_801901.1. NC_008510.1.

3D structure databases

ProteinModelPortali Q04PM7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355277.LBJ_2732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ77143 ; ABJ77143 ; LBJ_2732 .
GeneIDi 4410896.
KEGGi lbj:LBJ_2732.
PATRICi 22361662. VBILepBor13265_3518.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci LBOR355277:GHYM-2697-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JB197.

Entry informationi

Entry nameiGCSP_LEPBJ
AccessioniPrimary (citable) accession number: Q04PM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3