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Q04NB4

- PYRF_LEPBJ

UniProt

Q04NB4 - PYRF_LEPBJ

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton donorUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciLBOR355277:GHYM-3207-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:LBJ_4227
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Taxonomic identifieri355277 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000000656: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Orotidine 5'-phosphate decarboxylasePRO_1000138954Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi355277.LBJ_4227.

Structurei

3D structure databases

ProteinModelPortaliQ04NB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiDATHHLC.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04NB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFQSKFLTR SQSLKSLLCV GLDPDYCKLP EIIKRSPEPL VHFCREIIDA
60 70 80 90 100
TAPYAVAYKP NIAFFEVFGS SGIRQFEKVI GHLKNNYPQI PIVADIKRGD
110 120 130 140 150
LDNTARQYAR YYFGDLQVDS LTLSPYMGLD TLRPFLEYQD HLVFWLCLTS
160 170 180 190 200
SPDSIQFQKK RFSETGRTLY EEVAYVANSI SPLNLGFVVG ATNTYELEIL
210 220 230 240 250
RKQNPDRIFL IPGFGAQGAK LDDLLPVCGR YSLINSSRGI HFASDGLDFA
260 270
ARANQEAEKI HNAMQARFVF L
Length:271
Mass (Da):30,713
Last modified:November 14, 2006 - v1
Checksum:i990EB8770250EB7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000351 Genomic DNA. Translation: ABJ77606.1.
RefSeqiWP_011672216.1. NC_008511.1.
YP_802364.1. NC_008511.1.

Genome annotation databases

EnsemblBacteriaiABJ77606; ABJ77606; LBJ_4227.
GeneIDi4412299.
KEGGilbj:LBJ_4227.
PATRICi22362945. VBILepBor13265_4155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000351 Genomic DNA. Translation: ABJ77606.1 .
RefSeqi WP_011672216.1. NC_008511.1.
YP_802364.1. NC_008511.1.

3D structure databases

ProteinModelPortali Q04NB4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355277.LBJ_4227.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ77606 ; ABJ77606 ; LBJ_4227 .
GeneIDi 4412299.
KEGGi lbj:LBJ_4227.
PATRICi 22362945. VBILepBor13265_4155.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi DATHHLC.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci LBOR355277:GHYM-3207-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JB197.

Entry informationi

Entry nameiPYRF_LEPBJ
AccessioniPrimary (citable) accession number: Q04NB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 14, 2006
Last modified: November 26, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3