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Q04NB4 (PYRF_LEPBJ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:LBJ_4227
OrganismLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197) [Complete proteome] [HAMAP]
Taxonomic identifier355277 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_1000138954

Sites

Active site971Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04NB4 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 990EB8770250EB7E

FASTA27130,713
        10         20         30         40         50         60 
MNFQSKFLTR SQSLKSLLCV GLDPDYCKLP EIIKRSPEPL VHFCREIIDA TAPYAVAYKP 

        70         80         90        100        110        120 
NIAFFEVFGS SGIRQFEKVI GHLKNNYPQI PIVADIKRGD LDNTARQYAR YYFGDLQVDS 

       130        140        150        160        170        180 
LTLSPYMGLD TLRPFLEYQD HLVFWLCLTS SPDSIQFQKK RFSETGRTLY EEVAYVANSI 

       190        200        210        220        230        240 
SPLNLGFVVG ATNTYELEIL RKQNPDRIFL IPGFGAQGAK LDDLLPVCGR YSLINSSRGI 

       250        260        270 
HFASDGLDFA ARANQEAEKI HNAMQARFVF L 

« Hide

References

[1]"Genome reduction in Leptospira borgpetersenii reflects limited transmission potential."
Bulach D.M., Zuerner R.L., Wilson P., Seemann T., McGrath A., Cullen P.A., Davis J., Johnson M., Kuczek E., Alt D.P., Peterson-Burch B., Coppel R.L., Rood J.I., Davies J.K., Adler B.
Proc. Natl. Acad. Sci. U.S.A. 103:14560-14565(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JB197.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000351 Genomic DNA. Translation: ABJ77606.1.
RefSeqYP_802364.1. NC_008511.1.

3D structure databases

ProteinModelPortalQ04NB4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING355277.LBJ_4227.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ77606; ABJ77606; LBJ_4227.
GeneID4412299.
KEGGlbj:LBJ_4227.
PATRIC22362945. VBILepBor13265_4155.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245747.
KOK01591.
OMADATHHLC.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycLBOR355277:GHYM-3207-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRF_LEPBJ
AccessionPrimary (citable) accession number: Q04NB4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways