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Q04NA9

- Q04NA9_LEPBJ

UniProt

Q04NA9 - Q04NA9_LEPBJ

Protein

Alanine racemase

Gene

alr

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciLBOR355277:GHYM-3212-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:LBJ_4232Imported
    OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197)Imported
    Taxonomic identifieri355277 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000000656: Chromosome 2

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi355277.LBJ_4232.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04NA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiWRDMARR.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04NA9-1 [UniParc]FASTAAdd to Basket

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    MKETASSWIE ISKRSLSNNL NSFRSILRPG STLTAILKSN AYGHGTDLMA    50
    KLCIEEGVSH IGVNSIEEAQ SIRQIDPKIP ILIMGEIQNP EKRKEALSDP 100
    NFWIIFSRPE TARILSSLNP APKLHLKIDT GMGRLGNHGE TLKYTLGELK 150
    KNGITLDGIC THFASTEDVL EHKYSLMQIQ KFEKAVLLAE SLGYKNLIRH 200
    MCASASTMLF SSAHYEMVRV GISLYGLWPS IQTRLSLNLN GNKNFQLSPI 250
    LSWKTRIVHI QNHPADSYIG YGSTFQTSYP TKVAIVPIGY YEGLDRKLSS 300
    NGDMLVLGKR ARIIGRICMN MTMLDVTHIS GADVGSVVTV IGQDGEELIT 350
    ADDIADRTHT INYEITTRIS ESVCRIVVD 379
    Length:379
    Mass (Da):42,066
    Last modified:November 14, 2006 - v1
    Checksum:i4838C83698448241
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000351 Genomic DNA. Translation: ABJ77611.1.
    RefSeqiYP_802369.1. NC_008511.1.

    Genome annotation databases

    EnsemblBacteriaiABJ77611; ABJ77611; LBJ_4232.
    GeneIDi4412304.
    KEGGilbj:LBJ_4232.
    PATRICi22362959. VBILepBor13265_4162.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000351 Genomic DNA. Translation: ABJ77611.1 .
    RefSeqi YP_802369.1. NC_008511.1.

    3D structure databases

    ProteinModelPortali Q04NA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 355277.LBJ_4232.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ77611 ; ABJ77611 ; LBJ_4232 .
    GeneIDi 4412304.
    KEGGi lbj:LBJ_4232.
    PATRICi 22362959. VBILepBor13265_4162.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi WRDMARR.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci LBOR355277:GHYM-3212-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JB197Imported.

    Entry informationi

    Entry nameiQ04NA9_LEPBJ
    AccessioniPrimary (citable) accession number: Q04NA9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 14, 2006
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3