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Q04NA9

- Q04NA9_LEPBJ

UniProt

Q04NA9 - Q04NA9_LEPBJ

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Protein

Alanine racemase

Gene

alr

Organism
Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Active sitei271 – 2711Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei319 – 3191Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLBOR355277:GHYM-3212-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:LBJ_4232Imported
OrganismiLeptospira borgpetersenii serovar Hardjo-bovis (strain JB197)Imported
Taxonomic identifieri355277 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000000656: Chromosome 2

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi355277.LBJ_4232.

Structurei

3D structure databases

ProteinModelPortaliQ04NA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiWRDMARR.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04NA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKETASSWIE ISKRSLSNNL NSFRSILRPG STLTAILKSN AYGHGTDLMA
60 70 80 90 100
KLCIEEGVSH IGVNSIEEAQ SIRQIDPKIP ILIMGEIQNP EKRKEALSDP
110 120 130 140 150
NFWIIFSRPE TARILSSLNP APKLHLKIDT GMGRLGNHGE TLKYTLGELK
160 170 180 190 200
KNGITLDGIC THFASTEDVL EHKYSLMQIQ KFEKAVLLAE SLGYKNLIRH
210 220 230 240 250
MCASASTMLF SSAHYEMVRV GISLYGLWPS IQTRLSLNLN GNKNFQLSPI
260 270 280 290 300
LSWKTRIVHI QNHPADSYIG YGSTFQTSYP TKVAIVPIGY YEGLDRKLSS
310 320 330 340 350
NGDMLVLGKR ARIIGRICMN MTMLDVTHIS GADVGSVVTV IGQDGEELIT
360 370
ADDIADRTHT INYEITTRIS ESVCRIVVD
Length:379
Mass (Da):42,066
Last modified:November 14, 2006 - v1
Checksum:i4838C83698448241
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000351 Genomic DNA. Translation: ABJ77611.1.
RefSeqiYP_802369.1. NC_008511.1.

Genome annotation databases

EnsemblBacteriaiABJ77611; ABJ77611; LBJ_4232.
GeneIDi4412304.
KEGGilbj:LBJ_4232.
PATRICi22362959. VBILepBor13265_4162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000351 Genomic DNA. Translation: ABJ77611.1 .
RefSeqi YP_802369.1. NC_008511.1.

3D structure databases

ProteinModelPortali Q04NA9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355277.LBJ_4232.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ77611 ; ABJ77611 ; LBJ_4232 .
GeneIDi 4412304.
KEGGi lbj:LBJ_4232.
PATRICi 22362959. VBILepBor13265_4162.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi WRDMARR.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci LBOR355277:GHYM-3212-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JB197Imported.

Entry informationi

Entry nameiQ04NA9_LEPBJ
AccessioniPrimary (citable) accession number: Q04NA9
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3