Reviewed, UniProtKB/Swiss-Prot Q04M75 (MTLD_STRP2)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	SPD_0363

Organism

Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) [Complete proteome] [HAMAP]

Taxonomic identifier

373153 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011818
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q04M75-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 934C2686C51BF5A6	FASTA	378	42,991
	10 20 30 40 50 60 MKHSVHFGAG NIGRGFIGEI LFKNGFHIDF VDVNNQIIHA LNEKGKYEIE IAQKGQSRIE 70 80 90 100 110 120 VTNVAGINSK EHPEQVIEAI QKTDIITTAI GPNILPFIAE LLAKGIEARR VAGNTQVLDV 130 140 150 160 170 180 MACENMIGGS QFLYQEVKKY LSPEGLTFAD NYIGFPNAAV DRIVPAQSHE DSLFVVVEPF 190 200 210 220 230 240 NEWVVETKRL KNPDLRLKDV HYEEDLEPFI ERKLFSVNSG HATSAYIGAH YGAKTILEAL 250 260 270 280 290 300 QNPNIKSRIE SVLAEIRSLL IAKWNFDKKE LENYHKVIIE RFENPFIVDE VSRVARTPIR 310 320 330 340 350 360 KLGYNERFIR PIRELKELSL SYKNLLKTVG YAFDYRDVND EESIRLGELL AKQLVKDVVI 370 QVTGLDDQEL IEQIVEYI

References

[1]

"Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6." Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E. J. Bacteriol. 189:38-51(2007) [PubMed: 17041037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000410 Genomic DNA. Translation: ABJ54824.1.
RefSeq	YP_815873.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4443079.
GenomeReviews	Gene locus SPD_0363 in contig CP000410_GR.
KEGG	spd:SPD_0363.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q04M75. VDRIVPN.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_STRP2

Accession

Primary (citable) accession number: Q04M75

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)