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Reviewed, UniProtKB/Swiss-Prot Q04M75 (MTLD_STRP2)

Last modified November 25, 2008. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17
Gene names
Name: mtlD
Ordered Locus Names: SPD_0363
OrganismStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) [Complete proteome] [HAMAP]
Taxonomic identifier373153 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords

   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Mannitol-1-phosphate 5-dehydrogenase
PRO_1000011818

Regions

Nucleotide binding4 – 1512NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04M75-1 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 934C2686C51BF5A6

FASTA37842,991
        10         20         30         40         50         60 
MKHSVHFGAG NIGRGFIGEI LFKNGFHIDF VDVNNQIIHA LNEKGKYEIE IAQKGQSRIE 

        70         80         90        100        110        120 
VTNVAGINSK EHPEQVIEAI QKTDIITTAI GPNILPFIAE LLAKGIEARR VAGNTQVLDV 

       130        140        150        160        170        180 
MACENMIGGS QFLYQEVKKY LSPEGLTFAD NYIGFPNAAV DRIVPAQSHE DSLFVVVEPF 

       190        200        210        220        230        240 
NEWVVETKRL KNPDLRLKDV HYEEDLEPFI ERKLFSVNSG HATSAYIGAH YGAKTILEAL 

       250        260        270        280        290        300 
QNPNIKSRIE SVLAEIRSLL IAKWNFDKKE LENYHKVIIE RFENPFIVDE VSRVARTPIR 

       310        320        330        340        350        360 
KLGYNERFIR PIRELKELSL SYKNLLKTVG YAFDYRDVND EESIRLGELL AKQLVKDVVI 

       370 
QVTGLDDQEL IEQIVEYI 

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References

[1]"Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
J. Bacteriol. 189:38-51(2007) [PubMed: 17041037] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000410 Genomic DNA. Translation: ABJ54824.1.
RefSeqYP_815873.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4443079.
GenomeReviewsGene locus SPD_0363 in contig CP000410_GR.
KEGGspd:SPD_0363.

Organism-specific databases

CMRSearch...

Family and domain databases

HAMAPMF_00196.
[Tree]
InterProIPR013328. DHase_multihelical.
IPR013118. Mannitol_DHase_C.
IPR000669. Mannitol_DHase_core.
IPR013131. Mannitol_DHase_N.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_STRP2
AccessionPrimary (citable) accession number: Q04M75
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: November 25, 2008
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents