Q04M13 (Q04M13_STRP2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6-phospho-beta-galactosidase 1 HAMAP MF_01574
EC=3.2.1.85 HAMAP MF_01574

Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase 1 HAMAP MF_01574
P-beta-Gal 1 HAMAP MF_01574

Gene names

Name:	lacG-1 EMBL ABJ54778.1
Synonyms:	lacG1 HAMAP MF_01574
Ordered Locus Names:	SPD_0427

Organism

Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) [Complete proteome] [HAMAP] EMBL ABJ54778.1

Taxonomic identifier

373153 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. HAMAP MF_01574
Pathway	Carbohydrate metabolism; lactose degradation; D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1. HAMAP MF_01574
Sequence similarities	Belongs to the glycosyl hydrolase 1 family. HAMAP MF_01574

Ontologies

Keywords
Molecular function	Glycosidase HAMAP MF_01574 EMBL ABJ54778.1 Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: InterPro
Molecular function	6-phospho-beta-galactosidase activity Inferred from electronic annotation. Source: HAMAP cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	164	1	Proton donor By similarity HAMAP MF_01574
	Active site	378	1	Nucleophile By similarity HAMAP MF_01574

Sequences

	Sequence		Length	Mass (Da)
	Q04M13 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: CAE61D8921067D6D	FASTA	470	54,675
	10 20 30 40 50 60 MENLQVKALP KEFLLGTATA AYQVEGATRV DGKGINMWDV YLQENSPFLP DPASDFYYRY 70 80 90 100 110 120 EEDIALAAEH GLQALRLSIS WVRIFPDIDG DANVLAVHYY HRVFQSCLKH NVIPFVSLHH 130 140 150 160 170 180 FDSPQKMLET GDWLNRENID RFIRYARFCF QEFTEVKHWF TINELMSLAA GQYIGGQFPP 190 200 210 220 230 240 NHHFQLSEAI QANHNMLLAH ALAVLEFHQL GIEGKVGCIH ALKPGYPIDG QKENILAAKR 250 260 270 280 290 300 YDVYNNKFLL DGTFLGYYSE DTLFHLNQIL EANNSSFIIE DGDLEIMKRA APLNTMFVMN 310 320 330 340 350 360 YYRSEFIREY KGENRQEFNS TGIKGQSSFK LNALGEFVKK PGIPTTDWDW NIYPQGLFDM 370 380 390 400 410 420 LLRIKEEYPQ HPVIYLTENG TALKEVKPEG ENDIIDDSKR IRYIEQHLHK VLEARDRGVN 430 440 450 460 470 IQGYFIWSLQ DQFSWANGYN KRYGLFFVDY ETQKRYIKKS ALWVKGLKRN

References

[1]

"Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6." Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E. J. Bacteriol. 189:38-51(2007) [PubMed: 17041037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000410 Genomic DNA. Translation: ABJ54778.1.
RefSeq	YP_815935.1. NC_008533.1.
3D structure databases
ProteinModelPortal	Q04M13.
ModBase	Search...
Protein-protein interaction databases
STRING	Q04M13.
Protein family/group databases
CAZy	GH1. Glycoside Hydrolase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000020379; EBSTRP00000019619; EBSTRG00000020379.
GeneID	4443011.
GenomeReviews	Gene locus SPD_0427 in contig CP000410_GR.
KEGG	spd:SPD_0427.
PATRIC	19681870. VBIStrPne27904_0474.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2723.
GeneTree	EBGT00050000027409.
HOGENOM	HBG316462.
OMA	TEATNDY.
ProtClustDB	PRK13511.
Family and domain databases
HAMAP	MF_01574. LacG. [Tree]
InterPro	IPR005928. 6P-beta-galactosidase. IPR001360. Glyco_hydro_1. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KO	K01220.
PANTHER	PTHR10353. Glyco_hydro_1. 1 hit.
Pfam	PF00232. Glyco_hydro_1. 1 hit. [Graphical view]
PRINTS	PR00131. GLHYDRLASE1.
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
TIGRFAMs	TIGR01233. LacG. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q04M13_STRP2

Accession

Primary (citable) accession number: Q04M13

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	November 14, 2006
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)