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Q04LZ5

- PGK_STRP2

UniProt

Q04LZ5 - PGK_STRP2

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateUniRule annotation
    Binding sitei119 – 1191SubstrateUniRule annotation
    Binding sitei157 – 1571SubstrateUniRule annotation
    Binding sitei208 – 2081ATPUniRule annotation
    Binding sitei296 – 2961ATP; via carbonyl oxygenUniRule annotation
    Binding sitei327 – 3271ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi354 – 3574ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE373153:GIX6-445-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:SPD_0445
    OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
    Taxonomic identifieri373153 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001452: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Phosphoglycerate kinasePRO_1000009654Add
    BLAST

    PTM databases

    PhosSiteiP1001768.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi373153.SPD_0445.

    Structurei

    Secondary structure

    1
    398
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 83
    Beta strandi15 – 195
    Beta strandi30 – 323
    Helixi35 – 4915
    Beta strandi53 – 575
    Helixi66 – 683
    Helixi75 – 8511
    Beta strandi95 – 973
    Helixi98 – 1058
    Beta strandi112 – 1143
    Helixi118 – 1225
    Turni123 – 1253
    Turni127 – 1315
    Helixi133 – 1419
    Beta strandi143 – 1497
    Helixi152 – 1543
    Turni160 – 1623
    Helixi163 – 1664
    Beta strandi169 – 1746
    Helixi176 – 18510
    Helixi187 – 1904
    Beta strandi194 – 2007
    Turni206 – 2083
    Helixi209 – 21810
    Beta strandi220 – 2245
    Helixi228 – 2358
    Helixi247 – 2493
    Helixi250 – 25910
    Beta strandi270 – 2789
    Beta strandi282 – 2843
    Beta strandi286 – 2883
    Beta strandi295 – 2995
    Helixi301 – 31111
    Beta strandi315 – 3217
    Helixi329 – 3313
    Helixi333 – 34311
    Beta strandi349 – 3524
    Helixi355 – 3639
    Helixi367 – 3693
    Beta strandi370 – 3734
    Helixi378 – 3847
    Helixi390 – 3934

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZLBX-ray1.78A1-398[»]
    ProteinModelPortaliQ04LZ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 233Substrate bindingUniRule annotation
    Regioni59 – 624Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    KOiK00927.
    OMAiWEALDIG.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04LZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKLTVKDVD LKGKKVLVRV DFNVPLKDGV ITNDNRITAA LPTIKYIIEQ    50
    GGRAILFSHL GRVKEESDKA GKSLAPVAAD LAAKLGQDVV FPGVTRGAEL 100
    EAAINALEDG QVLLVENTRY EDVDGKKESK NDPELGKYWA SLGDGIFVND 150
    AFGTAHRAHA SNVGISANVE KAVAGFLLEN EIAYIQEAVE TPERPFVAIL 200
    GGSKVSDKIG VIENLLEKAD KVLIGGGMTY TFYKAQGIEI GNSLVEEDKL 250
    DVAKALLEKA NGKLILPVDS KEANAFAGYT EVRDTEGEAV SEGFLGLDIG 300
    PKSIAKFDEA LTGAKTVVWN GPMGVFENPD FQAGTIGVMD AIVKQPGVKS 350
    IIGGGDSAAA AINLGRADKF SWISTGGGAS MELLEGKVLP GLAALTEK 398
    Length:398
    Mass (Da):41,939
    Last modified:November 14, 2006 - v1
    Checksum:iBDDA8FD4B336BC91
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000410 Genomic DNA. Translation: ABJ54881.1.
    RefSeqiYP_815953.1. NC_008533.1.

    Genome annotation databases

    EnsemblBacteriaiABJ54881; ABJ54881; SPD_0445.
    GeneIDi4442109.
    KEGGispd:SPD_0445.
    PATRICi19681912. VBIStrPne27904_0495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000410 Genomic DNA. Translation: ABJ54881.1 .
    RefSeqi YP_815953.1. NC_008533.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZLB X-ray 1.78 A 1-398 [» ]
    ProteinModelPortali Q04LZ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 373153.SPD_0445.

    PTM databases

    PhosSitei P1001768.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ54881 ; ABJ54881 ; SPD_0445 .
    GeneIDi 4442109.
    KEGGi spd:SPD_0445.
    PATRICi 19681912. VBIStrPne27904_0495.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    KOi K00927.
    OMAi WEALDIG.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci SPNE373153:GIX6-445-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
      Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
      J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D39 / NCTC 7466.

    Entry informationi

    Entry nameiPGK_STRP2
    AccessioniPrimary (citable) accession number: Q04LZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3