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Q04LZ5

- PGK_STRP2

UniProt

Q04LZ5 - PGK_STRP2

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Protein
Phosphoglycerate kinase
Gene
pgk, SPD_0445
Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Substrate By similarity
Binding sitei119 – 1191Substrate By similarity
Binding sitei157 – 1571Substrate By similarity
Binding sitei208 – 2081ATP By similarity
Binding sitei296 – 2961ATP; via carbonyl oxygen By similarity
Binding sitei327 – 3271ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi354 – 3574ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-445-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:SPD_0445
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001452: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Phosphoglycerate kinaseUniRule annotation
PRO_1000009654Add
BLAST

PTM databases

PhosSiteiP1001768.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi373153.SPD_0445.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83
Beta strandi15 – 195
Beta strandi30 – 323
Helixi35 – 4915
Beta strandi53 – 575
Helixi66 – 683
Helixi75 – 8511
Beta strandi95 – 973
Helixi98 – 1058
Beta strandi112 – 1143
Helixi118 – 1225
Turni123 – 1253
Turni127 – 1315
Helixi133 – 1419
Beta strandi143 – 1497
Helixi152 – 1543
Turni160 – 1623
Helixi163 – 1664
Beta strandi169 – 1746
Helixi176 – 18510
Helixi187 – 1904
Beta strandi194 – 2007
Turni206 – 2083
Helixi209 – 21810
Beta strandi220 – 2245
Helixi228 – 2358
Helixi247 – 2493
Helixi250 – 25910
Beta strandi270 – 2789
Beta strandi282 – 2843
Beta strandi286 – 2883
Beta strandi295 – 2995
Helixi301 – 31111
Beta strandi315 – 3217
Helixi329 – 3313
Helixi333 – 34311
Beta strandi349 – 3524
Helixi355 – 3639
Helixi367 – 3693
Beta strandi370 – 3734
Helixi378 – 3847
Helixi390 – 3934

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZLBX-ray1.78A1-398[»]
ProteinModelPortaliQ04LZ5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate binding By similarity
Regioni59 – 624Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiWEALDIG.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04LZ5-1 [UniParc]FASTAAdd to Basket

« Hide

MAKLTVKDVD LKGKKVLVRV DFNVPLKDGV ITNDNRITAA LPTIKYIIEQ    50
GGRAILFSHL GRVKEESDKA GKSLAPVAAD LAAKLGQDVV FPGVTRGAEL 100
EAAINALEDG QVLLVENTRY EDVDGKKESK NDPELGKYWA SLGDGIFVND 150
AFGTAHRAHA SNVGISANVE KAVAGFLLEN EIAYIQEAVE TPERPFVAIL 200
GGSKVSDKIG VIENLLEKAD KVLIGGGMTY TFYKAQGIEI GNSLVEEDKL 250
DVAKALLEKA NGKLILPVDS KEANAFAGYT EVRDTEGEAV SEGFLGLDIG 300
PKSIAKFDEA LTGAKTVVWN GPMGVFENPD FQAGTIGVMD AIVKQPGVKS 350
IIGGGDSAAA AINLGRADKF SWISTGGGAS MELLEGKVLP GLAALTEK 398
Length:398
Mass (Da):41,939
Last modified:November 14, 2006 - v1
Checksum:iBDDA8FD4B336BC91
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000410 Genomic DNA. Translation: ABJ54881.1.
RefSeqiYP_815953.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ54881; ABJ54881; SPD_0445.
GeneIDi4442109.
KEGGispd:SPD_0445.
PATRICi19681912. VBIStrPne27904_0495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000410 Genomic DNA. Translation: ABJ54881.1 .
RefSeqi YP_815953.1. NC_008533.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZLB X-ray 1.78 A 1-398 [» ]
ProteinModelPortali Q04LZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 373153.SPD_0445.

PTM databases

PhosSitei P1001768.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ54881 ; ABJ54881 ; SPD_0445 .
GeneIDi 4442109.
KEGGi spd:SPD_0445.
PATRICi 19681912. VBIStrPne27904_0495.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227107.
KOi K00927.
OMAi WEALDIG.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci SPNE373153:GIX6-445-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
    Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
    J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D39 / NCTC 7466.

Entry informationi

Entry nameiPGK_STRP2
AccessioniPrimary (citable) accession number: Q04LZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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