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Q04LT1 (Q04LT1_STRP2) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Cysteine--tRNA ligase HAMAP-Rule MF_00041

EC=6.1.1.16 HAMAP-Rule MF_00041
Alternative name(s):
Cysteinyl-tRNA synthetase HAMAP-Rule MF_00041
Gene names
Name:cysS HAMAP-Rule MF_00041 EMBL ABJ55485.1
Ordered Locus Names:SPD_0515 EMBL ABJ55485.1
OrganismStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) [Complete proteome] [HAMAP] EMBL ABJ55485.1
Taxonomic identifier373153 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). HAMAP-Rule MF_00041

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00041 SAAS SAAS015273

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00041

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00041 SAAS SAAS015273.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. HAMAP-Rule MF_00041

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif30 – 4011"HIGH" region By similarity HAMAP-Rule MF_00041
Motif268 – 2725"KMSKS" region By similarity HAMAP-Rule MF_00041

Sites

Metal binding281Zinc By similarity HAMAP-Rule MF_00041
Metal binding2111Zinc By similarity HAMAP-Rule MF_00041
Metal binding2361Zinc By similarity HAMAP-Rule MF_00041
Metal binding2401Zinc By similarity HAMAP-Rule MF_00041
Binding site2711ATP By similarity HAMAP-Rule MF_00041

Sequences

Sequence LengthMass (Da)Tools
Q04LT1 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: D8D0ED3F63D7958E

FASTA44751,081
        10         20         30         40         50         60 
MIKIYDTMSR DLREFVPIED GKIKMYVCGP TVYNYIHVGN ARSTVAFDTI RRYFEYRGYK 

        70         80         90        100        110        120 
VAYISNFTDV DDKIINRARE EGITPQEVAD KYIAAFREDV TALGVKPATR HPRVVEFMAD 

       130        140        150        160        170        180 
IIRFVEDLIE RGFAYESQGD VYFRVEKSHN YAKLANKTLE DLELGASGRT DEETARKENP 

       190        200        210        220        230        240 
VDFALWKSSK PGEISWDSPW GPGRPGWHIE CSVMSTEILG DTIDIHGGGA DLEFPHHTNE 

       250        260        270        280        290        300 
IAQSEAKTGK AFANYWMHNG FVNIDNVKMS KSLGNFITVH DALKTLDGQV LRFFFATQHY 

       310        320        330        340        350        360 
RKPINFTEKA VRDAETNLKY LKNTYEQPFT GNVDAQELQN FKDKFVAAMD EDFNAANGIT 

       370        380        390        400        410        420 
VVFEMAKWIN SGNYDASVKQ ALADMLEIFG IVFVEEVLDA EIEDLIQKRQ EARANRDFET 

       430        440 
ADQIRDQLVT QGIKLLDTKD GVRWTRD 

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References

[1]"Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
Lanie J.A., Ng W.L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: D39 / NCTC 7466.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000410 Genomic DNA. Translation: ABJ55485.1.
RefSeqYP_816017.1. NC_008533.1.

3D structure databases

ProteinModelPortalQ04LT1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING373153.SPD_0515.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ55485; ABJ55485; SPD_0515.
GeneID4441826.
KEGGspd:SPD_0515.
PATRIC19682078. VBIStrPne27904_0579.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0215.
HOGENOMHOG000245250.
KOK01883.
OMAMHADFDA.
OrthoDBEOG6RVFXC.

Enzyme and pathway databases

BioCycSPNE373153:GIX6-515-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00041. Cys_tRNA_synth.
InterProIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR001943. UVR_dom.
[Graphical view]
PANTHERPTHR10890. PTHR10890. 1 hit.
PfamPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSPR00983. TRNASYNTHCYS.
SMARTSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00435. cysS. 1 hit.
PROSITEPS50151. UVR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ04LT1_STRP2
AccessionPrimary (citable) accession number: Q04LT1
Entry history
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)