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Q04LL8

- TYSY_STRP2

UniProt

Q04LL8 - TYSY_STRP2

Protein

Thymidylate synthase

Gene

thyA

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei154 – 1541UniRule annotation

    GO - Molecular functioni

    1. thymidylate synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dTMP biosynthetic process Source: UniProtKB-HAMAP
    2. dTTP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciSPNE373153:GIX6-581-MONOMER.
    UniPathwayiUPA00575.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
    Short name:
    TSUniRule annotation
    Short name:
    TSaseUniRule annotation
    Gene namesi
    Name:thyAUniRule annotation
    Ordered Locus Names:SPD_0581
    OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
    Taxonomic identifieri373153 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001452: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Thymidylate synthasePRO_1000000692Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi373153.SPD_0581.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04LL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0207.
    HOGENOMiHOG000257898.
    KOiK00560.
    OMAiELLWIYQ.
    OrthoDBiEOG6K6V53.

    Family and domain databases

    Gene3Di3.30.572.10. 1 hit.
    HAMAPiMF_00008. Thymidy_synth_bact.
    InterProiIPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view]
    PfamiPF00303. Thymidylat_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00108. THYMDSNTHASE.
    SUPFAMiSSF55831. SSF55831. 1 hit.
    PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04LL8-1 [UniParc]FASTAAdd to Basket

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    MTKADTIFKE NIERILKEGV FSEQARPKYK DGTVANSKYV TGAFSEYDLS    50
    KGEFPITTLR PIAIKSAIKE VLWIYQDQSN SLEVLNDKYN VHYWNDWEVG 100
    DTGTIGERYG AVVKKHDIIN KLLKQLETNP WNRRNIISLW DYQAFEETDG 150
    LLPCAFQTMF DVRRVDGEIY LDATLTQRSN DMLVAHHINA MQYVALQMMI 200
    AKHFGWKVGK FFYFINNLHI YDNQFEQAQE LLRREPSNCQ PRLVLNVPDG 250
    TNFFDIKAED FELVDYDPVK PQLKFDLAI 279
    Length:279
    Mass (Da):32,554
    Last modified:November 14, 2006 - v1
    Checksum:i3A1FC537CA648C6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000410 Genomic DNA. Translation: ABJ54489.1.
    RefSeqiYP_816080.1. NC_008533.1.

    Genome annotation databases

    EnsemblBacteriaiABJ54489; ABJ54489; SPD_0581.
    GeneIDi4441151.
    KEGGispd:SPD_0581.
    PATRICi19682242. VBIStrPne27904_0661.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000410 Genomic DNA. Translation: ABJ54489.1 .
    RefSeqi YP_816080.1. NC_008533.1.

    3D structure databases

    ProteinModelPortali Q04LL8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 373153.SPD_0581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ54489 ; ABJ54489 ; SPD_0581 .
    GeneIDi 4441151.
    KEGGi spd:SPD_0581.
    PATRICi 19682242. VBIStrPne27904_0661.

    Phylogenomic databases

    eggNOGi COG0207.
    HOGENOMi HOG000257898.
    KOi K00560.
    OMAi ELLWIYQ.
    OrthoDBi EOG6K6V53.

    Enzyme and pathway databases

    UniPathwayi UPA00575 .
    BioCyci SPNE373153:GIX6-581-MONOMER.

    Family and domain databases

    Gene3Di 3.30.572.10. 1 hit.
    HAMAPi MF_00008. Thymidy_synth_bact.
    InterProi IPR023451. Thymidate_synth/dCMP_Mease.
    IPR000398. Thymidylate_synthase.
    IPR020940. Thymidylate_synthase_AS.
    [Graphical view ]
    Pfami PF00303. Thymidylat_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00108. THYMDSNTHASE.
    SUPFAMi SSF55831. SSF55831. 1 hit.
    PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
      Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
      J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D39 / NCTC 7466.

    Entry informationi

    Entry nameiTYSY_STRP2
    AccessioniPrimary (citable) accession number: Q04LL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3