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Protein
Submitted name:

PTS system, IIABC components

Gene

exp5

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.SAAS annotation

GO - Molecular functioni

  1. kinase activity Source: UniProtKB-KW
  2. protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Biological processi

Phosphotransferase systemSAAS annotation, Sugar transportSAAS annotation, Transport

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-661-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
PTS system, IIABC componentsImported (EC:2.7.1.69Imported)
Gene namesi
Name:exp5Imported
Ordered Locus Names:SPD_0661Imported
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)Imported
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001452 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Interactioni

Protein-protein interaction databases

STRINGi373153.SPD_0661.

Structurei

3D structure databases

ProteinModelPortaliQ04LE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains PTS EIIA type-1 domain.SAAS annotation
Contains PTS EIIB type-1 domain.SAAS annotation
Contains PTS EIIC type-1 domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

eggNOGiCOG1263.
HOGENOMiHOG000250993.
KOiK02777.
K02778.
K02779.
OMAiEVDACMT.
OrthoDBiEOG6FFS9V.

Family and domain databases

Gene3Di3.30.1360.60. 1 hit.
InterProiIPR011055. Dup_hybrid_motif.
IPR018113. PTrfase_EIIB_Cys.
IPR001127. PTS_EIIA_1_perm.
IPR003352. PTS_EIIC.
IPR013013. PTS_EIIC_1.
IPR001996. PTS_IIB_1.
IPR011300. PTS_IIBC.
[Graphical view]
PfamiPF00358. PTS_EIIA_1. 1 hit.
PF00367. PTS_EIIB. 1 hit.
PF02378. PTS_EIIC. 1 hit.
[Graphical view]
SUPFAMiSSF51261. SSF51261. 1 hit.
SSF55604. SSF55604. 1 hit.
TIGRFAMsiTIGR00826. EIIB_glc. 1 hit.
TIGR00830. PTBA. 1 hit.
TIGR02003. PTS-II-BC-unk1. 1 hit.
PROSITEiPS51093. PTS_EIIA_TYPE_1. 1 hit.
PS00371. PTS_EIIA_TYPE_1_HIS. 1 hit.
PS51098. PTS_EIIB_TYPE_1. 1 hit.
PS01035. PTS_EIIB_TYPE_1_CYS. 1 hit.
PS51103. PTS_EIIC_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04LE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKDTFKNVL SFEFWQKFGK ALMVVIAVMP AAGLMISIGK SIVMINPTFA
60 70 80 90 100
PLVITGGILE QIGWGVIGNL HILFALAIGG SWAKERAGGA FAAGLAFILI
110 120 130 140 150
NRITGTIFGV SGDMLKNPDA MVTTFFGGSI KVADYFISVL EAPALNMGVF
160 170 180 190 200
VGIISGFVGA TAYNKYYNFR KLPDALSFFN GKRFVPFVVI LRSAIAAILL
210 220 230 240 250
AAFWPVVQTG INNFGIWIAN SQETAPILAP FLYGTLERLL LPFGLHHMLT
260 270 280 290 300
IPMNYTALGG TYDILTGAAK GTQVFGQDPL WLAWVTDLVN LKGTDASQYQ
310 320 330 340 350
HLLDTVHPAR FKVGQMIGSF GILMGVIVAI YRNVDADKKH KYKGMMIATA
360 370 380 390 400
LATFLTGVTE PIEYMFMFIA TPMYLVYSLV QGAAFAMADV VNLRMHSFGS
410 420 430 440 450
IEFLTRTPIA ISAGIGMDIV NFVWVTVLFA VIMYFIANFM IQKFNYATPG
460 470 480 490 500
RNGNYETAEG SEETSSEVKV AAGSQAVNII NLLGGRVNIV DVDACMTRLR
510 520 530 540 550
VTVKDADKVG NAEQWKAEGA MGLVMKGQGV QAIYGPKADI LKSDIQDILD
560 570 580 590 600
SGEIIPETLP SQMTEVQQNT VHFKDLTEEV YSVADGQVVA LEQVKDPVFA
610 620 630 640 650
QKMMGDGFAV EPANGNIVSP VSGTVSSIFP TKHAFGIVTE AGLEVLVHIG
660 670 680 690 700
LDTVSLEGKP FTVHVAEGQK VAAGDLLVTA DLNAIRAAGR ETSTVVVFTN
710 720
GDAIKSVKLE KTGSLAAKTA VAKVEL
Length:726
Mass (Da):78,022
Last modified:November 14, 2006 - v1
Checksum:iFB6607966B53F261
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ55450.1.
RefSeqiYP_816155.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ55450; ABJ55450; SPD_0661.
GeneIDi4441868.
KEGGispd:SPD_0661.
PATRICi19682416. VBIStrPne27904_0748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ55450.1.
RefSeqiYP_816155.1. NC_008533.1.

3D structure databases

ProteinModelPortaliQ04LE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi373153.SPD_0661.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ55450; ABJ55450; SPD_0661.
GeneIDi4441868.
KEGGispd:SPD_0661.
PATRICi19682416. VBIStrPne27904_0748.

Phylogenomic databases

eggNOGiCOG1263.
HOGENOMiHOG000250993.
KOiK02777.
K02778.
K02779.
OMAiEVDACMT.
OrthoDBiEOG6FFS9V.

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-661-MONOMER.

Family and domain databases

Gene3Di3.30.1360.60. 1 hit.
InterProiIPR011055. Dup_hybrid_motif.
IPR018113. PTrfase_EIIB_Cys.
IPR001127. PTS_EIIA_1_perm.
IPR003352. PTS_EIIC.
IPR013013. PTS_EIIC_1.
IPR001996. PTS_IIB_1.
IPR011300. PTS_IIBC.
[Graphical view]
PfamiPF00358. PTS_EIIA_1. 1 hit.
PF00367. PTS_EIIB. 1 hit.
PF02378. PTS_EIIC. 1 hit.
[Graphical view]
SUPFAMiSSF51261. SSF51261. 1 hit.
SSF55604. SSF55604. 1 hit.
TIGRFAMsiTIGR00826. EIIB_glc. 1 hit.
TIGR00830. PTBA. 1 hit.
TIGR02003. PTS-II-BC-unk1. 1 hit.
PROSITEiPS51093. PTS_EIIA_TYPE_1. 1 hit.
PS00371. PTS_EIIA_TYPE_1_HIS. 1 hit.
PS51098. PTS_EIIB_TYPE_1. 1 hit.
PS01035. PTS_EIIB_TYPE_1_CYS. 1 hit.
PS51103. PTS_EIIC_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
    Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
    J. Bacteriol. 189:38-51(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D39 / NCTC 7466Imported.

Entry informationi

Entry nameiQ04LE3_STRP2
AccessioniPrimary (citable) accession number: Q04LE3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: March 4, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.