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Protein

Putative agmatine deiminase

Gene

aguA

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Agmatine + H2O = N-carbamoylputrescine + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei354 – 3541Amidino-cysteine intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-814-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative agmatine deiminaseUniRule annotation (EC:3.5.3.12UniRule annotation)
Alternative name(s):
Agmatine iminohydrolaseUniRule annotation
Gene namesi
Name:aguAUniRule annotation
Ordered Locus Names:SPD_0814
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001452 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Putative agmatine deiminasePRO_1000070575Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi373153.SPD_0814.

Structurei

3D structure databases

ProteinModelPortaliQ04L01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the agmatine deiminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWY. Bacteria.
COG2957. LUCA.
HOGENOMiHOG000239346.
KOiK10536.
OMAiEVLLAWT.
OrthoDBiEOG6M3PB5.

Family and domain databases

HAMAPiMF_01841. Agmatine_deimin.
InterProiIPR017754. Agmatine_deiminase.
IPR007466. Peptidyl-Arg-deiminase_porph.
[Graphical view]
PfamiPF04371. PAD_porph. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03380. agmatine_aguA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04L01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDSPKKLGY HMPAEYEPHH GTLMIWPIRP GSWPFQGKAA KRAFTQIIET
60 70 80 90 100
IAEGERVYLL VEQAYLSEAQ SYLGDKVVYL DIPTNDAWAR DTGPTILVND
110 120 130 140 150
KGKKLAVDWA FNAWGGTYDG LYQDYEEDDQ VASRFAEALE RPVYDAKPFV
160 170 180 190 200
LEGGAIHSDG QGTILVTESC LLSPGRNPNL TKEEIENTLL ESLGAEKVIW
210 220 230 240 250
LPYGIYQDET NEHVDNVVAF VGPAEVVLAW TDDENDPQYA MSKADLELLE
260 270 280 290 300
QETDAKGCHF TIHKLPIPAV RQVVTEEDLP GYIYEEGEEE RYAGERLAAS
310 320 330 340 350
YVNFYIANKA VLVPQFEDVN DQVALDILSK CFPDRKVVGI PARDILLGGG
360
NIHCITQQIP E
Length:361
Mass (Da):40,368
Last modified:November 14, 2006 - v1
Checksum:i01C3EF5042777FC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ54341.1.
RefSeqiWP_000969442.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ54341; ABJ54341; SPD_0814.
KEGGispd:SPD_0814.
PATRICi19682762. VBIStrPne27904_0918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ54341.1.
RefSeqiWP_000969442.1. NC_008533.1.

3D structure databases

ProteinModelPortaliQ04L01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi373153.SPD_0814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ54341; ABJ54341; SPD_0814.
KEGGispd:SPD_0814.
PATRICi19682762. VBIStrPne27904_0918.

Phylogenomic databases

eggNOGiENOG4105DWY. Bacteria.
COG2957. LUCA.
HOGENOMiHOG000239346.
KOiK10536.
OMAiEVLLAWT.
OrthoDBiEOG6M3PB5.

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-814-MONOMER.

Family and domain databases

HAMAPiMF_01841. Agmatine_deimin.
InterProiIPR017754. Agmatine_deiminase.
IPR007466. Peptidyl-Arg-deiminase_porph.
[Graphical view]
PfamiPF04371. PAD_porph. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03380. agmatine_aguA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
    Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
    J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D39 / NCTC 7466.

Entry informationi

Entry nameiAGUA_STRP2
AccessioniPrimary (citable) accession number: Q04L01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: November 11, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.