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Q04KI9

- NADK_STRP2

UniProt

Q04KI9 - NADK_STRP2

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Protein
NAD kinase
Gene
nadK, SPD_0983
Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton acceptor By similarity
Binding sitei152 – 1521NAD By similarity
Binding sitei154 – 1541NAD By similarity
Binding sitei189 – 1891NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 512NAD By similarity
Nucleotide bindingi126 – 1272NAD By similarity
Nucleotide bindingi165 – 1706NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-983-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:SPD_0983
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001452: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272NAD kinaseUniRule annotation
PRO_1000005447Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi373153.SPD_0983.

Structurei

3D structure databases

ProteinModelPortaliQ04KI9.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000275803.
KOiK00858.
OMAiIQMSEIA.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04KI9-1 [UniParc]FASTAAdd to Basket

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MKNTGKRIDL IANRKPQSQR VLYELRDRLK RNQFILNDTN PDIVISIGGD    50
GMLLSAFHKY ENQLDKVRFI GLHTGHLGFY TDYRDFELDK LVTNLQLDTG 100
ARVSYPVLNV KVFLENGEVK IFRALNEASI RRSDRTMVAD IVINGVPFER 150
FRGDGLTVST PTGSTAYNKS LGGAVLHPTI EALQLTEIAS LNNRVYRTLG 200
SSIIVPKKDK IELIPTRNDY HTISVDNSVY SFRNIERIEY QIDHHKIHFV 250
ATPSHTSFWN RVKDAFIGEV DE 272
Length:272
Mass (Da):31,035
Last modified:November 14, 2006 - v1
Checksum:iB9C8FC6FE604B594
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000410 Genomic DNA. Translation: ABJ54161.1.
RefSeqiYP_816459.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ54161; ABJ54161; SPD_0983.
GeneIDi4441101.
KEGGispd:SPD_0983.
PATRICi19683128. VBIStrPne27904_1099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000410 Genomic DNA. Translation: ABJ54161.1 .
RefSeqi YP_816459.1. NC_008533.1.

3D structure databases

ProteinModelPortali Q04KI9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 373153.SPD_0983.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ54161 ; ABJ54161 ; SPD_0983 .
GeneIDi 4441101.
KEGGi spd:SPD_0983.
PATRICi 19683128. VBIStrPne27904_1099.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000275803.
KOi K00858.
OMAi IQMSEIA.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci SPNE373153:GIX6-983-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
    Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
    J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D39 / NCTC 7466.

Entry informationi

Entry nameiNADK_STRP2
AccessioniPrimary (citable) accession number: Q04KI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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