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Protein

Galactose-6-phosphate isomerase subunit LacA

Gene

lacA

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-galactose 6-phosphate = D-tagatose 6-phosphate.UniRule annotation

Pathwayi: D-galactose 6-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Galactose-6-phosphate isomerase subunit LacB (lacB), Galactose-6-phosphate isomerase subunit LacA (lacA)
This subpathway is part of the pathway D-galactose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate, the pathway D-galactose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-1053-MONOMER.
UniPathwayiUPA00702; UER00714.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-6-phosphate isomerase subunit LacAUniRule annotation (EC:5.3.1.26UniRule annotation)
Gene namesi
Name:lacAUniRule annotation
Ordered Locus Names:SPD_1053
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001452 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Galactose-6-phosphate isomerase subunit LacAPRO_1000068924Add
BLAST

Interactioni

Subunit structurei

Heteromultimeric protein consisting of LacA and LacB.UniRule annotation

Protein-protein interaction databases

STRINGi373153.SPD_1053.

Structurei

3D structure databases

ProteinModelPortaliQ04KC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LacAB/RpiB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105RSI. Bacteria.
COG0698. LUCA.
HOGENOMiHOG000226301.
KOiK01819.
OMAiRMITVGA.
OrthoDBiEOG6X9MQG.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01555. LacA.
InterProiIPR004783. LacA.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01118. lacA. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04KC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIVIGADAA GLRLKEVVKD FLEKENFHLV DVTAEGQDFV DVTLAVAAEV
60 70 80 90 100
NKEEQNLGIV IDAYGAGPFM VATKIKGMVA AEVSDERSAY MTRGHNNSRM
110 120 130 140
ITMGAQLVGD ELAKNIAKGF VNGKYDGGRH QIRVDMLNKM G
Length:141
Mass (Da):15,244
Last modified:November 14, 2006 - v1
Checksum:iBF0C9F8FAF1445A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ54186.1.
RefSeqiWP_000029272.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ54186; ABJ54186; SPD_1053.
KEGGispd:SPD_1053.
PATRICi19683278. VBIStrPne27904_1174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ54186.1.
RefSeqiWP_000029272.1. NC_008533.1.

3D structure databases

ProteinModelPortaliQ04KC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi373153.SPD_1053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ54186; ABJ54186; SPD_1053.
KEGGispd:SPD_1053.
PATRICi19683278. VBIStrPne27904_1174.

Phylogenomic databases

eggNOGiENOG4105RSI. Bacteria.
COG0698. LUCA.
HOGENOMiHOG000226301.
KOiK01819.
OMAiRMITVGA.
OrthoDBiEOG6X9MQG.

Enzyme and pathway databases

UniPathwayiUPA00702; UER00714.
BioCyciSPNE373153:GIX6-1053-MONOMER.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01555. LacA.
InterProiIPR004783. LacA.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01118. lacA. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
    Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
    J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D39 / NCTC 7466.

Entry informationi

Entry nameiLACA_STRP2
AccessioniPrimary (citable) accession number: Q04KC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: November 11, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.