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Protein

Galactose-6-phosphate isomerase subunit LacA

Gene

lacA

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-galactose 6-phosphate = D-tagatose 6-phosphate.UniRule annotation

Pathwayi: D-galactose 6-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Galactose-6-phosphate isomerase subunit LacB (lacB), Galactose-6-phosphate isomerase subunit LacA (lacA)
This subpathway is part of the pathway D-galactose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate, the pathway D-galactose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processLactose metabolism

Enzyme and pathway databases

UniPathwayiUPA00702; UER00714.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-6-phosphate isomerase subunit LacAUniRule annotation (EC:5.3.1.26UniRule annotation)
Gene namesi
Name:lacAUniRule annotation
Ordered Locus Names:SPD_1053
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001452 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000689241 – 141Galactose-6-phosphate isomerase subunit LacAAdd BLAST141

Interactioni

Subunit structurei

Heteromultimeric protein consisting of LacA and LacB.UniRule annotation

Protein-protein interaction databases

STRINGi373153.SPD_1053.

Structurei

3D structure databases

ProteinModelPortaliQ04KC1.
SMRiQ04KC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LacAB/RpiB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105RSI. Bacteria.
COG0698. LUCA.
HOGENOMiHOG000226301.
KOiK01819.
OMAiLKVTHEV.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01555. LacA. 1 hit.
InterProiView protein in InterPro
IPR004783. LacA.
IPR003500. RpiB_LacA_LacB.
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiView protein in Pfam
PF02502. LacAB_rpiB. 1 hit.
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01118. lacA. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04KC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIVIGADAA GLRLKEVVKD FLEKENFHLV DVTAEGQDFV DVTLAVAAEV
60 70 80 90 100
NKEEQNLGIV IDAYGAGPFM VATKIKGMVA AEVSDERSAY MTRGHNNSRM
110 120 130 140
ITMGAQLVGD ELAKNIAKGF VNGKYDGGRH QIRVDMLNKM G
Length:141
Mass (Da):15,244
Last modified:November 14, 2006 - v1
Checksum:iBF0C9F8FAF1445A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ54186.1.
RefSeqiWP_000029272.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ54186; ABJ54186; SPD_1053.
KEGGispd:SPD_1053.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLACA_STRP2
AccessioniPrimary (citable) accession number: Q04KC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: June 7, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families