Reviewed, UniProtKB/Swiss-Prot Q04KC1 (LACA_STRP2)

Names and origin

Protein names

Recommended name:
    Galactose-6-phosphate isomerase subunit lacA
    EC=5.3.1.26

Gene names

Name:	lacA
Ordered Locus Names:	SPD_1053

Organism

Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) [Complete proteome] [HAMAP]

Taxonomic identifier

373153 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	141 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-galactose 6-phosphate = D-tagatose 6-phosphate. HAMAP MF_01555
Pathway	Carbohydrate metabolism; galactose degradation; D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1. HAMAP MF_01555
Subunit structure	Heteromultimeric protein consisting of lacA and lacB By similarity.
Sequence similarities	Belongs to the lacAB/rpiB family.

Ontologies

Keywords
Biological process	Lactose metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: HAMAP
Molecular function	galactose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 141	141	Galactose-6-phosphate isomerase subunit lacA HAMAP MF_01555		PRO_1000068924

Sequences

	Sequence		Length	Mass (Da)
	Q04KC1-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: BF0C9F8FAF1445A9	FASTA	141	15,244
	10 20 30 40 50 60 MSIVIGADAA GLRLKEVVKD FLEKENFHLV DVTAEGQDFV DVTLAVAAEV NKEEQNLGIV 70 80 90 100 110 120 IDAYGAGPFM VATKIKGMVA AEVSDERSAY MTRGHNNSRM ITMGAQLVGD ELAKNIAKGF 130 140 VNGKYDGGRH QIRVDMLNKM G

References

[1]

"Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6." Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E. J. Bacteriol. 189:38-51(2007) [PubMed: 17041037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000410 Genomic DNA. Translation: ABJ54186.1.
RefSeq	YP_816527.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4441388.
GenomeReviews	Gene locus SPD_1053 in contig CP000410_GR.
KEGG	spd:SPD_1053.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q04KC1. SAMASNK.
Family and domain databases
HAMAP	MF_01555. [Tree]
InterPro	IPR004783. LacA. IPR003500. Rib/Gal_isomrase. [Graphical view]
Gene3D	G3DSA:3.40.1400.10. Rib/Gal_isomrase. 1 hit.
Pfam	PF02502. LacAB_rpiB. 1 hit. [Graphical view]
PIRSF	PIRSF005384. RpiB_LacA_B. 1 hit.
TIGRFAMs	TIGR01118. lacA. 1 hit. TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LACA_STRP2

Accession

Primary (citable) accession number: Q04KC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 14, 2006
Last modified:	June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)