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Protein

tRNA pseudouridine synthase B

Gene

truB

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase BUniRule annotation (EC:5.4.99.25UniRule annotation)
Alternative name(s):
tRNA pseudouridine(55) synthaseUniRule annotation
Short name:
Psi55 synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:SPD_1070
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000001452 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000846961 – 292tRNA pseudouridine synthase BAdd BLAST292

Interactioni

Protein-protein interaction databases

STRINGi373153.SPD_1070.

Structurei

3D structure databases

ProteinModelPortaliQ04KA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0T. Bacteria.
COG0130. LUCA.
HOGENOMiHOG000231225.
KOiK03177.
OMAiYELQFIR.

Family and domain databases

HAMAPiMF_01080. TruB_bact. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR032819. TruB_C.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04KA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGIINLKKE AGMTSHDAVF KLRKILGTKK IGHGGTLDPD VVGVLPIAVG
60 70 80 90 100
KATRMVEFMQ DEGKIYEGEI ILGYSTTTED ASGEVVAETP VLSSLDEKLV
110 120 130 140 150
DEAIASLTGP ITQIPPMYSA VKVNGRKLYE YARAGQEVER PERQVIIYQF
160 170 180 190 200
ERTSPISYDG QLARFTFRVK CSKGTYIRTL SVDLGEKLGY AAHMSHLTRT
210 220 230 240 250
SAAGLQLEDA LALEEIAEKV EAGQLDFLHP LEIGTGDLVK VFLTPEEATE
260 270 280 290
VRFGRFIELD QTDKELAAFE DDKLLAILEK RGNLYKPRKV FS
Length:292
Mass (Da):32,256
Last modified:November 14, 2006 - v1
Checksum:i2716D45FFC2E145E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ54024.1.
RefSeqiWP_001013236.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ54024; ABJ54024; SPD_1070.
KEGGispd:SPD_1070.
PATRICi19683316. VBIStrPne27904_1193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ54024.1.
RefSeqiWP_001013236.1. NC_008533.1.

3D structure databases

ProteinModelPortaliQ04KA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi373153.SPD_1070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ54024; ABJ54024; SPD_1070.
KEGGispd:SPD_1070.
PATRICi19683316. VBIStrPne27904_1193.

Phylogenomic databases

eggNOGiENOG4105D0T. Bacteria.
COG0130. LUCA.
HOGENOMiHOG000231225.
KOiK03177.
OMAiYELQFIR.

Family and domain databases

HAMAPiMF_01080. TruB_bact. 1 hit.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR032819. TruB_C.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRUB_STRP2
AccessioniPrimary (citable) accession number: Q04KA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 14, 2006
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.