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Q04K90

- FTHS_STRP2

UniProt

Q04K90 - FTHS_STRP2

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE373153:GIX6-1087-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:SPD_1087
    OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
    Taxonomic identifieri373153 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001452: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000300547Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi373153.SPD_1087.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04K90.
    SMRiQ04K90. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04K90-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIAQS IELKPIVDVV EKLGISYDDL ELYGKYKAKL SFDKIRAVES    50
    NPVGKLILVT AINPTPAGEG KSTLTIGLAD ALNKIGKKTM IAIREPSLGP 100
    VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLHQ 150
    GNELGIDQRR ILWKRVVDLN DRALRHVTVG LGGPLNGIPR EDGFDITVAS 200
    EIMAILCLAT DIEDLKRRLA NIVIGYRYDR TPVSVGDLQV EGALALILKD 250
    AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATTTALH LADYTVTEAG 300
    FGADLGAEKF LDIKTPNLPT SPDAVVIVAT LRALKMNGGV AKDALTEENV 350
    EAVRAGFANL KRHVENIRKF GIPAVVAINE FVSDTEAEIA VLKELCASID 400
    VPVELASVWA DGAEGGVALA ETVVKTIAEN PANYKRLYDN DLSVQEKIEK 450
    IVTEIYRGSK VNFEKKSQTQ IAQIVQNGWD KLPICMAKTQ YSFSDNPNAL 500
    GAPENFEITI RELVPKLGAG FIVALTGDVM TMPGLPKRPA ALNMDVESDG 550
    TVLGLF 556
    Length:556
    Mass (Da):59,630
    Last modified:November 14, 2006 - v1
    Checksum:i025035A325CF97FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000410 Genomic DNA. Translation: ABJ55341.1.
    RefSeqiYP_816558.1. NC_008533.1.

    Genome annotation databases

    EnsemblBacteriaiABJ55341; ABJ55341; SPD_1087.
    GeneIDi4442359.
    KEGGispd:SPD_1087.
    PATRICi19683352. VBIStrPne27904_1211.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000410 Genomic DNA. Translation: ABJ55341.1 .
    RefSeqi YP_816558.1. NC_008533.1.

    3D structure databases

    ProteinModelPortali Q04K90.
    SMRi Q04K90. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 373153.SPD_1087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ55341 ; ABJ55341 ; SPD_1087 .
    GeneIDi 4442359.
    KEGGi spd:SPD_1087.
    PATRICi 19683352. VBIStrPne27904_1211.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SPNE373153:GIX6-1087-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
      Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
      J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D39 / NCTC 7466.

    Entry informationi

    Entry nameiFTHS_STRP2
    AccessioniPrimary (citable) accession number: Q04K90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3