Q04K46 (PYRB_STRP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	SPD_1133

Organism

Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) [Complete proteome] [HAMAP]

Taxonomic identifier

373153 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000321162

Sequences

	Sequence		Length	Mass (Da)
	Q04K46 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 34208B4A16839663	FASTA	307	34,706
	10 20 30 40 50 60 MSENQQALNH VVSMEDLTVD QVMKLIKRGI EFKNGAQIPY EDHPIVSNLF FEDSTRTHKS 70 80 90 100 110 120 FEVAEIKLGL ERLDFDVKTS SVNKGETLYD TILTLSALGV DVCVIRHPEV DYYRELIASP 130 140 150 160 170 180 TITTSIINGG DGSGQHPSQS LLDLMTIYEE FGHFEGLKVA IAGDLDHSRV AKSNMQILKR 190 200 210 220 230 240 LGSELFFAGP EEWRSQEFAD YGKFVTIDEI IDQVDVMMFL RVQHERHDSG AVFSKEDYHA 250 260 270 280 290 300 QHGLTQERYD RLKETAILMH PAPINRDVEI ADHLVEAPKS RIVQQMTNGV FVRMAILESV LASRNAN

References

[1]

"Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6." Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E. J. Bacteriol. 189:38-51(2007) [PubMed: 17041037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: D39 / NCTC 7466.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000410 Genomic DNA. Translation: ABJ55115.1.
RefSeq	YP_816602.1. NC_008533.1.
3D structure databases
ProteinModelPortal	Q04K46.
ModBase	Search...
Protein-protein interaction databases
STRING	Q04K46.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000020483; EBSTRP00000019723; EBSTRG00000020483.
GeneID	4442176.
GenomeReviews	Gene locus SPD_1133 in contig CP000410_GR.
KEGG	spd:SPD_1133.
PATRIC	19683450. VBIStrPne27904_1259.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0540.
GeneTree	EBGT00050000027081.
HOGENOM	HBG579429.
OMA	VGIPIIN.
ProtClustDB	PRK00856.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_STRP2

Accession

Primary (citable) accession number: Q04K46

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program