ID   WHIA_STRP2              Reviewed;         303 AA.
AC   Q04JI4;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   RecName: Full=Probable cell division protein WhiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   Name=whiA {ECO:0000255|HAMAP-Rule:MF_01420};
GN   OrderedLocusNames=SPD_1394;
OS   Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=373153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D39 / NCTC 7466;
RX   PubMed=17041037; DOI=10.1128/jb.01148-06;
RA   Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M.,
RA   Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.;
RT   "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus
RT   pneumoniae and comparison with that of unencapsulated laboratory strain
RT   R6.";
RL   J. Bacteriol. 189:38-51(2007).
CC   -!- FUNCTION: Involved in cell division and chromosome segregation.
CC       {ECO:0000255|HAMAP-Rule:MF_01420}.
CC   -!- SIMILARITY: Belongs to the WhiA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01420}.
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DR   EMBL; CP000410; ABJ53810.1; -; Genomic_DNA.
DR   RefSeq; WP_000011306.1; NZ_JAMLJR010000008.1.
DR   AlphaFoldDB; Q04JI4; -.
DR   SMR; Q04JI4; -.
DR   PaxDb; 373153-SPD_1394; -.
DR   KEGG; spd:SPD_1394; -.
DR   eggNOG; COG1481; Bacteria.
DR   HOGENOM; CLU_053282_0_0_9; -.
DR   BioCyc; SPNE373153:G1G6V-1500-MONOMER; -.
DR   Proteomes; UP000001452; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0043937; P:regulation of sporulation; IEA:InterPro.
DR   Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR   HAMAP; MF_01420; HTH_type_WhiA; 1.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR018478; Sporu_reg_WhiA_N_dom.
DR   InterPro; IPR003802; Sporulation_regulator_WhiA.
DR   InterPro; IPR023054; Sporulation_regulator_WhiA_C.
DR   InterPro; IPR039518; WhiA_LAGLIDADG_dom.
DR   NCBIfam; TIGR00647; DNA_bind_WhiA; 1.
DR   PANTHER; PTHR37307; CELL DIVISION PROTEIN WHIA-RELATED; 1.
DR   PANTHER; PTHR37307:SF1; CELL DIVISION PROTEIN WHIA-RELATED; 1.
DR   Pfam; PF02650; HTH_WhiA; 1.
DR   Pfam; PF14527; LAGLIDADG_WhiA; 1.
DR   Pfam; PF10298; WhiA_N; 1.
DR   SUPFAM; SSF55608; Homing endonucleases; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; DNA-binding; Reference proteome.
FT   CHAIN           1..303
FT                   /note="Probable cell division protein WhiA"
FT                   /id="PRO_0000376581"
FT   DNA_BIND        272..303
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01420"
SQ   SEQUENCE   303 AA;  34092 MW;  AF33FFE6D2578400 CRC64;
     MSFTVAVKEE ILGQHHLSWH ELSAIIKMSG SIGLSTSGLT LSVVTENAKL ARHLYESFLH
     FYEIKSEIRH HQRSNLRKNR VYTVFTDEKV QDLLSDLHLA DSFFGLETGI DEAILSDEEA
     GRAYLCGAFL ANGSIRDPES GKYQLEISSV YLDHAQGIAS LLQQFLLDAK VLERKKGAVT
     YLQRAEDIMD FLIVIGAMQA RDDFERVKIL RETRNDLNRA NNAETANIAR TVSASMKTIN
     NISKIKDIMG LENLPVDLQE VAQLRIQHPD YSIQQLADSL STPLTKSGVN HRLRKINKIA
     DEL
//