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Q04JB4

- GPMA_STRP2

UniProt

Q04JB4 - GPMA_STRP2

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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene
gpmA, SPD_1468
Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91Tele-phosphohistidine intermediate By similarity
Binding sitei15 – 1512-phospho-D-glycerate By similarity
Binding sitei60 – 6012-phospho-D-glycerate By similarity
Binding sitei98 – 9812-phospho-D-glycerate By similarity
Active sitei182 – 1821 By similarity
Binding sitei184 – 18412-phospho-D-glycerate By similarity

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-1468-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (EC:5.4.2.11)
Short name:
BPG-dependent PGAM
Short name:
PGAM
Short name:
Phosphoglyceromutase
Short name:
dPGM
Gene namesi
Name:gpmA
Ordered Locus Names:SPD_1468
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001452: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2302302,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotationPRO_1000064104Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi373153.SPD_1468.

Structurei

3D structure databases

ProteinModelPortaliQ04JB4.
SMRiQ04JB4. Positions 1-229.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 2222-phospho-D-glycerate binding By similarity
Regioni87 – 9042-phospho-D-glycerate binding By similarity
Regioni114 – 11522-phospho-D-glycerate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0588.
HOGENOMiHOG000221682.
KOiK01834.
OMAiKDDERFP.
OrthoDBiEOG6C8N1H.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04JB4-1 [UniParc]FASTAAdd to Basket

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MVKLVFARHG ESEWNKANLF TGWADVDLSE KGTQQAIDAG KLIKEAGIEF    50
DQAYTSVLKR AIKTTNLALE ASDQLWVPVE KSWRLNERHY GGLTGKNKAE 100
AAEQFGDEQV HIWRRSYDVL PPNMDRDDEH SAHTDRRYAS LDDSVIPDAE 150
NLKVTLERAL PFWEDKIAPA LKDGKNVFVG AHGNSIRALV KHIKGLSDDE 200
IMDVEIPNFP PLVFEFDEKL NVVSEYYLGK 230
Length:230
Mass (Da):26,051
Last modified:November 14, 2006 - v1
Checksum:i35076152D4DEAB00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000410 Genomic DNA. Translation: ABJ54957.1.
RefSeqiYP_816924.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ54957; ABJ54957; SPD_1468.
GeneIDi4442440.
KEGGispd:SPD_1468.
PATRICi19684185. VBIStrPne27904_1624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000410 Genomic DNA. Translation: ABJ54957.1 .
RefSeqi YP_816924.1. NC_008533.1.

3D structure databases

ProteinModelPortali Q04JB4.
SMRi Q04JB4. Positions 1-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 373153.SPD_1468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ54957 ; ABJ54957 ; SPD_1468 .
GeneIDi 4442440.
KEGGi spd:SPD_1468.
PATRICi 19684185. VBIStrPne27904_1624.

Phylogenomic databases

eggNOGi COG0588.
HOGENOMi HOG000221682.
KOi K01834.
OMAi KDDERFP.
OrthoDBi EOG6C8N1H.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00186 .
BioCyci SPNE373153:GIX6-1468-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
HAMAPi MF_01039. PGAM_GpmA.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR005952. Phosphogly_mut1.
[Graphical view ]
PANTHERi PTHR11931. PTHR11931. 1 hit.
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
TIGRFAMsi TIGR01258. pgm_1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
    Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
    J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D39 / NCTC 7466.

Entry informationi

Entry nameiGPMA_STRP2
AccessioniPrimary (citable) accession number: Q04JB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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