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Protein
Submitted name:

Sialidase B

Gene

nanB

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseImported, Hydrolase

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-1499-MONOMER.

Protein family/group databases

CAZyiCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Sialidase BImported (EC:3.2.1.18Imported)
Gene namesi
Name:nanBImported
Ordered Locus Names:SPD_1499Imported
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)Imported
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001452 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi373153.SPD_1499.

Structurei

3D structure databases

ProteinModelPortaliQ04J83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000285031.
KOiK01186.
OMAiWRYHYDI.
OrthoDBiEOG61CM2G.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.40.220.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR002860. BNR_rpt.
IPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR011040. Sialidases.
IPR023364. Trans_sialidase_dom3.
[Graphical view]
PfamiPF02012. BNR. 1 hit.
PF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.

Sequencei

Sequence statusi: Complete.

Q04J83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKRGLYSKL GISVVGISLL MGVPALIHAN ELNYGQLSIS PIFQGGSYQL
60 70 80 90 100
NNKSIDISPL LLDKLSGDSQ TVVMKFKADK PNSLQALFGL SNSKAGFKNN
110 120 130 140 150
YFSIFMRDSG EIGVEIRDAQ KGINYLFSRP ASLWGKHKGQ AVENTLVFVS
160 170 180 190 200
DSKDKTYTMY VNGIEVFSET VDTFLPISNI NGIDKATLGA VNREGKEHYL
210 220 230 240 250
AKGSIDEISL FNKAISDQEV STIPLSNPFQ LIFQSGDSTQ ANYFRIPTLY
260 270 280 290 300
TLSSGRVLSS IDARYGGTHD SKSKINIATS YSDDNGKTWS EPIFAMKFND
310 320 330 340 350
YEEQLVYWPR DNKLKNSQIS GSASFIDSSI VEDKKSGKTI LLADVMPAGI
360 370 380 390 400
GNNNANKADS GFKEINGHYY LKLKKNGDND FRYTVRENGV VYDETTNKPT
410 420 430 440 450
NYTINDKYEV LEGGKSLTVE QYSVDFDSGS LRERHNGKQV PMNVFYKDSL
460 470 480 490 500
FKVTPTNYIA MTTSQNRGES WEQFKLLPPF LGEKHNGTYL CPGQGLALKS
510 520 530 540 550
SNRLIFATYT SGELTYLISD DSGQTWKKSS ASIPFENATA EAQMVELRDG
560 570 580 590 600
VIRTFFRTTT GKIAYMTSRD SGETWSEVSY IDGIQQTSYG TQVSAIKYSQ
610 620 630 640 650
LIDGKEAVIL STPNSRSGRK GGQLVVGLVN KEDDSIDWKY HYDIDLPSYG
660 670 680 690
YAYSAITELP NHHIGVLFEK YDSWSRNELH LSNVVQYIDL EINDLTK
Length:697
Mass (Da):77,664
Last modified:November 14, 2006 - v1
Checksum:i38766D2F6747AE53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ55283.1.
RefSeqiYP_816955.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ55283; ABJ55283; SPD_1499.
GeneIDi4442008.
KEGGispd:SPD_1499.
PATRICi19684251. VBIStrPne27904_1657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ55283.1.
RefSeqiYP_816955.1. NC_008533.1.

3D structure databases

ProteinModelPortaliQ04J83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi373153.SPD_1499.

Protein family/group databases

CAZyiCBM40. Carbohydrate-Binding Module Family 40.
GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ55283; ABJ55283; SPD_1499.
GeneIDi4442008.
KEGGispd:SPD_1499.
PATRICi19684251. VBIStrPne27904_1657.

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000285031.
KOiK01186.
OMAiWRYHYDI.
OrthoDBiEOG61CM2G.

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-1499-MONOMER.

Family and domain databases

Gene3Di2.120.10.10. 2 hits.
2.40.220.10. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR002860. BNR_rpt.
IPR013320. ConA-like_dom.
IPR004124. Glyco_hydro_33_N.
IPR011040. Sialidases.
IPR023364. Trans_sialidase_dom3.
[Graphical view]
PfamiPF02012. BNR. 1 hit.
PF02973. Sialidase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF50939. SSF50939. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
    Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
    J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D39 / NCTC 7466Imported.

Entry informationi

Entry nameiQ04J83_STRP2
AccessioniPrimary (citable) accession number: Q04J83
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: January 7, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.