SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q04J42

- PHPP_STRP2

UniProt

Q04J42 - PHPP_STRP2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein phosphatase PhpP

Gene
phpP, SPD_1543
Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity By similarity. Also dephosphorylates DivIVA in vivo.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Manganese 1 By similarity
Metal bindingi36 – 361Manganese 2 By similarity
Metal bindingi37 – 371Manganese 1; via carbonyl oxygen By similarity
Metal bindingi192 – 1921Manganese 2 By similarity
Metal bindingi231 – 2311Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSPNE373153:GIX6-1543-MONOMER.

Protein family/group databases

PptaseDBiP3D1211217.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PhpP (EC:3.1.3.16)
Alternative name(s):
PP2C-type phosphatase
Ser/Thr phosphoprotein phosphatase
Short name:
STPP
Gene namesi
Name:phpP
Ordered Locus Names:SPD_1543
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000001452: Chromosome

Subcellular locationi

Cytoplasm
Note: Mainly localizes to the midcell division sites in a StkP-dependent manner, since PhpP is present at midcell only when StkP is active.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Protein phosphatase PhpPPRO_0000418149Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi373153.SPD_1543.

Structurei

3D structure databases

ProteinModelPortaliQ04J42.
SMRiQ04J42. Positions 1-238.

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000235782.
KOiK01090.
OMAiHEECQGM.
OrthoDBiEOG65N17S.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04J42-1 [UniParc]FASTAAdd to Basket

« Hide

MEISLLTDVG QKRTNNQDYV NHYVNRAGRT MIILADGMGG HRAGNIASEM    50
AVTDLGVAWV DTQIDTVNEV REWFAHYLEI ENQKIHQLGQ DEAYRGMGTT 100
LEVLAIIDNQ AIYAHIGDSR IGLIRGEEYH QLTSDHSLVN ELLKAGQLTP 150
EEAEAHPQKN IITQSIGQKD EIQPDFGTVI LESGDYLLLN SDGLTNMISG 200
SEIRDIVTSD IPLADKTETL VRFANNAGGL DNITVALVSM NEEDAE 246
Length:246
Mass (Da):27,103
Last modified:November 14, 2006 - v1
Checksum:iC7D368C6ECE86E94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000410 Genomic DNA. Translation: ABJ54228.1.
RefSeqiYP_816996.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ54228; ABJ54228; SPD_1543.
GeneIDi4441334.
KEGGispd:SPD_1543.
PATRICi19684355. VBIStrPne27904_1711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000410 Genomic DNA. Translation: ABJ54228.1 .
RefSeqi YP_816996.1. NC_008533.1.

3D structure databases

ProteinModelPortali Q04J42.
SMRi Q04J42. Positions 1-238.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 373153.SPD_1543.

Protein family/group databases

PptaseDBi P3D1211217.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ54228 ; ABJ54228 ; SPD_1543 .
GeneIDi 4441334.
KEGGi spd:SPD_1543.
PATRICi 19684355. VBIStrPne27904_1711.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000235782.
KOi K01090.
OMAi HEECQGM.
OrthoDBi EOG65N17S.

Enzyme and pathway databases

BioCyci SPNE373153:GIX6-1543-MONOMER.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
    Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
    J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: D39 / NCTC 7466.
  2. "Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP."
    Beilharz K., Novakova L., Fadda D., Branny P., Massidda O., Veening J.W.
    Proc. Natl. Acad. Sci. U.S.A. 109:E905-E913(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
    Strain: D39 / NCTC 7466.

Entry informationi

Entry nameiPHPP_STRP2
AccessioniPrimary (citable) accession number: Q04J42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi