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Q04J42

- PHPP_STRP2

UniProt

Q04J42 - PHPP_STRP2

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Protein
Protein phosphatase PhpP
Gene
phpP, SPD_1543
Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity By similarity. Also dephosphorylates DivIVA in vivo.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Manganese 1 By similarity
Metal bindingi36 – 361Manganese 2 By similarity
Metal bindingi37 – 371Manganese 1; via carbonyl oxygen By similarity
Metal bindingi192 – 1921Manganese 2 By similarity
Metal bindingi231 – 2311Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSPNE373153:GIX6-1543-MONOMER.

    Protein family/group databases

    PptaseDBiP3D1211217.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase PhpP (EC:3.1.3.16)
    Alternative name(s):
    PP2C-type phosphatase
    Ser/Thr phosphoprotein phosphatase
    Short name:
    STPP
    Gene namesi
    Name:phpP
    Ordered Locus Names:SPD_1543
    OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
    Taxonomic identifieri373153 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000001452: Chromosome

    Subcellular locationi

    Cytoplasm
    Note: Mainly localizes to the midcell division sites in a StkP-dependent manner, since PhpP is present at midcell only when StkP is active.1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Protein phosphatase PhpP
    PRO_0000418149Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi373153.SPD_1543.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04J42.
    SMRiQ04J42. Positions 1-238.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000235782.
    KOiK01090.
    OMAiHEECQGM.
    OrthoDBiEOG65N17S.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q04J42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEISLLTDVG QKRTNNQDYV NHYVNRAGRT MIILADGMGG HRAGNIASEM    50
    AVTDLGVAWV DTQIDTVNEV REWFAHYLEI ENQKIHQLGQ DEAYRGMGTT 100
    LEVLAIIDNQ AIYAHIGDSR IGLIRGEEYH QLTSDHSLVN ELLKAGQLTP 150
    EEAEAHPQKN IITQSIGQKD EIQPDFGTVI LESGDYLLLN SDGLTNMISG 200
    SEIRDIVTSD IPLADKTETL VRFANNAGGL DNITVALVSM NEEDAE 246
    Length:246
    Mass (Da):27,103
    Last modified:November 14, 2006 - v1
    Checksum:iC7D368C6ECE86E94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000410 Genomic DNA. Translation: ABJ54228.1.
    RefSeqiYP_816996.1. NC_008533.1.

    Genome annotation databases

    EnsemblBacteriaiABJ54228; ABJ54228; SPD_1543.
    GeneIDi4441334.
    KEGGispd:SPD_1543.
    PATRICi19684355. VBIStrPne27904_1711.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000410 Genomic DNA. Translation: ABJ54228.1 .
    RefSeqi YP_816996.1. NC_008533.1.

    3D structure databases

    ProteinModelPortali Q04J42.
    SMRi Q04J42. Positions 1-238.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 373153.SPD_1543.

    Protein family/group databases

    PptaseDBi P3D1211217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ54228 ; ABJ54228 ; SPD_1543 .
    GeneIDi 4441334.
    KEGGi spd:SPD_1543.
    PATRICi 19684355. VBIStrPne27904_1711.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000235782.
    KOi K01090.
    OMAi HEECQGM.
    OrthoDBi EOG65N17S.

    Enzyme and pathway databases

    BioCyci SPNE373153:GIX6-1543-MONOMER.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
      Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
      J. Bacteriol. 189:38-51(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: D39 / NCTC 7466.
    2. "Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP."
      Beilharz K., Novakova L., Fadda D., Branny P., Massidda O., Veening J.W.
      Proc. Natl. Acad. Sci. U.S.A. 109:E905-E913(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
      Strain: D39 / NCTC 7466.

    Entry informationi

    Entry nameiPHPP_STRP2
    AccessioniPrimary (citable) accession number: Q04J42
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2012
    Last sequence update: November 14, 2006
    Last modified: May 14, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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