ID   FUCI_STRP2              Reviewed;         588 AA.
AC   Q04I16;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=L-fucose isomerase;
DE            EC=5.3.1.25;
DE   AltName: Full=6-deoxy-L-galactose isomerase;
DE   AltName: Full=FucIase;
GN   Name=fucI; OrderedLocusNames=SPD_1986;
OS   Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466).
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=373153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17041037; DOI=10.1128/JB.01148-06;
RA   Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M.,
RA   Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.;
RT   "Genome sequence of Avery's virulent serotype 2 strain D39 of
RT   Streptococcus pneumoniae and comparison with that of unencapsulated
RT   laboratory strain R6.";
RL   J. Bacteriol. 189:38-51(2007).
CC   -!- FUNCTION: Converts the aldose L-fucose into the corresponding
CC       ketose L-fuculose (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-fucose = L-fuculose.
CC   -!- COFACTOR: Manganese (By similarity).
CC   -!- PATHWAY: Carbohydrate degradation; L-fucose degradation; L-
CC       lactaldehyde and glycerone phosphate from L-fucose: step 1/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the L-fucose isomerase family.
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DR   EMBL; CP000410; ABJ54752.1; -; Genomic_DNA.
DR   RefSeq; YP_817372.1; -.
DR   GeneID; 4442576; -.
DR   GenomeReviews; CP000410_GR; SPD_1986.
DR   KEGG; spd:SPD_1986; -.
DR   OMA; Q04I16; TWFVPRL.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008736; F:L-fucose isomerase activity; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019317; P:fucose catabolic process; IEA:InterPro.
DR   HAMAP; MF_01254; -; 1.
DR   InterPro; IPR015888; Fuc_isomerase-like_C.
DR   InterPro; IPR004216; Fuc_isomerase_C.
DR   InterPro; IPR012888; Fucose_iso_N1.
DR   InterPro; IPR005763; Fucose_isomerase.
DR   InterPro; IPR012889; Fucose_isomerase_N2.
DR   Gene3D; G3DSA:3.20.14.10; Fuc_isomerase_C; 1.
DR   Gene3D; G3DSA:3.40.50.1070; Fucose_iso_N1; 1.
DR   Gene3D; G3DSA:3.40.275.10; Fucose_iso_N2; 1.
DR   Pfam; PF02952; Fucose_iso_C; 1.
DR   Pfam; PF07881; Fucose_iso_N1; 1.
DR   Pfam; PF07882; Fucose_iso_N2; 1.
DR   TIGRFAMs; TIGR01089; fucI; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Fucose metabolism; Isomerase; Manganese; Metal-binding.
FT   CHAIN         1    588       L-fucose isomerase.
FT                                /FTId=PRO_1000067227.
FT   ACT_SITE    335    335       Proton acceptor (By similarity).
FT   ACT_SITE    359    359       Proton acceptor (By similarity).
FT   METAL       335    335       Manganese (By similarity).
FT   METAL       359    359       Manganese (By similarity).
FT   METAL       525    525       Manganese (By similarity).
SQ   SEQUENCE   588 AA;  65850 MW;  4C114F7C5D67D559 CRC64;
     MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP VECVISPSTI
     GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD IPHAIWGFNG TERPGAVYLA
     AVLASHAQKG IPAFGIYGRD VQEASDTAIP EDVKEKLLRY ARAALATGLM RDTAYLSMGS
     VSMGIGGSIV NPDFFQEYLG MRNESVDMTE FTRRMDRGIY DPEEFERALK WVKENVKEGF
     DHNREDLVLS REEKDRQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ
     RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL TNTPQIFADV
     RTYWSPEAVE RVTGYTLEGR AAAGFLHLIN SGSCTLDGTG QATRDGKPVM KPFWELDESE
     VQAMLENTDF PPANREYFRG GGFSTRFLTK GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL
     PEDVHHTLDN RTDPGWPTTW FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL
     ASMLRIPVNM HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK
//