fucI

Functionⁱ

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityⁱ

L-fucopyranose = L-fuculose.UniRule annotation

Cofactorⁱ

Mn²⁺UniRule annotation

Pathwayⁱ: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:

L-fucose isomerase (fucI)
no protein annotated in this organism
no protein annotated in this organism

This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	335	Proton acceptorUniRule annotation	1
Metal bindingⁱ	335	ManganeseUniRule annotation	1
Active siteⁱ	359	Proton acceptorUniRule annotation	1
Metal bindingⁱ	359	ManganeseUniRule annotation	1
Metal bindingⁱ	525	ManganeseUniRule annotation	1

GO - Molecular functionⁱ

L-fucose isomerase activity Source: UniProtKB-EC
manganese ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fucose catabolic process Source: UniProtKB-UniPathway

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Carbohydrate metabolism, Fucose metabolism
Ligand	Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00563; UER00624.

UniPathwayⁱ

UPA00563; UER00624.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation) Alternative name(s): 6-deoxy-L-galactose isomeraseUniRule annotation FucIase
Gene namesⁱ	Name:fucIUniRule annotation Ordered Locus Names:SPD_1986
Organismⁱ	Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifierⁱ	373153 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae
Proteomesⁱ	UP000001452 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_01254

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000067227	1 – 588	L-fucose isomeraseAdd BLAST		588

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	373153.SPD_1986.

STRINGⁱ

373153.SPD_1986.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q04I16.
SMRⁱ	Q04I16.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105EHF. Bacteria. COG2407. LUCA.
HOGENOMⁱ	HOG000249674.
KEGG Orthology (KO) More...KOⁱ	K01818.
OMAⁱ	HAQKGLP.

Family and domain databases

Gene3Dⁱ	3.20.14.10. 1 hit. 3.40.275.10. 1 hit. 3.40.50.1070. 1 hit.
HAMAPⁱ	MF_01254. Fucose_iso. 1 hit.
InterProⁱ	View protein in InterPro IPR004216. Fuc/Ara_isomerase_C. IPR038393. Fuc_iso_dom3_sf. IPR015888. Fuc_isomerase_C. IPR038391. Fucose_iso_dom1_sf. IPR012888. Fucose_iso_N1. IPR005763. Fucose_isomerase. IPR038392. Fucose_isomerase_dom2_sf. IPR009015. Fucose_isomerase_N/cen_sf. IPR012889. Fucose_isomerase_N2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02952. Fucose_iso_C. 1 hit. PF07881. Fucose_iso_N1. 1 hit. PF07882. Fucose_iso_N2. 1 hit.
SUPFAMⁱ	SSF50443. SSF50443. 1 hit. SSF53743. SSF53743. 1 hit.
TIGRFAMsⁱ	TIGR01089. fucI. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q04I16-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP 
        60         70         80         90        100
VECVISPSTI GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD 
       110        120        130        140        150
IPHAIWGFNG TERPGAVYLA AVLASHAQKG IPAFGIYGRD VQEASDTAIP 
       160        170        180        190        200
EDVKEKLLRY ARAALATGLM RDTAYLSMGS VSMGIGGSIV NPDFFQEYLG 
       210        220        230        240        250
MRNESVDMTE FTRRMDRGIY DPEEFERALK WVKENVKEGF DHNREDLVLS 
       260        270        280        290        300
REEKDRQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ 
       310        320        330        340        350
RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL 
       360        370        380        390        400
TNTPQIFADV RTYWSPEAVE RVTGYTLEGR AAAGFLHLIN SGSCTLDGTG 
       410        420        430        440        450
QATRDGKPVM KPFWELDESE VQAMLENTDF PPANREYFRG GGFSTRFLTK 
       460        470        480        490        500
GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL PEDVHHTLDN RTDPGWPTTW 
       510        520        530        540        550
FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL ASMLRIPVNM 
       560        570        580 
HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK

Length:588

Mass (Da):65,850

Last modified:November 14, 2006 - v1

Checksum:ⁱ4C114F7C5D67D559

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000410 Genomic DNA. Translation: ABJ54752.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_000614258.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABJ54752; ABJ54752; SPD_1986.
KEGGⁱ	spd:SPD_1986.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q04I16	Q8DN24 A0A0U0HJA9	Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Streptococcus pneumoniae	588	UniRef100_Q04I16	Cluster: L-fucose isomerase	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q04I16	Q97N97 UPI0003D10207 UPI000B3F5AFF UPI000999D7BF UPI0003D1020B UPI0003D101CE C8NG58 UPI0002DBFD94 F2BPN8 UPI0002F144A0 +382	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Streptococcus pneumoniae Granulicatella adiacens ATCC 49175 Granulicatella adiacens Streptococcus sanguinis SK1057 Streptococcus sanguinis Streptococcus sanguinis SK355 Streptococcus sanguinis SK330 Streptococcus sanguinis SK115 Streptococcus pneumoniae GA49447 And more	588	UniRef90_Q97N97	Cluster: L-fucose isomerase	393

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q04I16	Q97N97 UPI0003D10207 UPI000B3F5AFF UPI000999D7BF UPI0003D1020B UPI0003D101CE C8NG58 UPI0002DBFD94 F2C961 F0IBA4 +485	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Streptococcus pneumoniae Granulicatella adiacens ATCC 49175 Granulicatella adiacens Streptococcus sanguinis SK330 Streptococcus sanguinis SK115 Streptococcus sanguinis Streptococcus sanguinis SK355 Streptococcus sanguinis SK1057 Abiotrophia defectiva ATCC 49176 And more	588	UniRef50_Q97N97	Cluster: L-fucose isomerase	496

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000410 Genomic DNA. Translation: ABJ54752.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_000614258.1. NC_008533.1.

3D structure databases

ProteinModelPortalⁱ	Q04I16.
SMRⁱ	Q04I16.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	373153.SPD_1986.

STRINGⁱ

373153.SPD_1986.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABJ54752; ABJ54752; SPD_1986.
KEGGⁱ	spd:SPD_1986.

Phylogenomic databases

eggNOGⁱ	ENOG4105EHF. Bacteria. COG2407. LUCA.
HOGENOMⁱ	HOG000249674.
KEGG Orthology (KO) More...KOⁱ	K01818.
OMAⁱ	HAQKGLP.

Enzyme and pathway databases

UniPathwayⁱ	UPA00563; UER00624.

UniPathwayⁱ

UPA00563; UER00624.

Family and domain databases

Gene3Dⁱ	3.20.14.10. 1 hit. 3.40.275.10. 1 hit. 3.40.50.1070. 1 hit.
HAMAPⁱ	MF_01254. Fucose_iso. 1 hit.
InterProⁱ	View protein in InterPro IPR004216. Fuc/Ara_isomerase_C. IPR038393. Fuc_iso_dom3_sf. IPR015888. Fuc_isomerase_C. IPR038391. Fucose_iso_dom1_sf. IPR012888. Fucose_iso_N1. IPR005763. Fucose_isomerase. IPR038392. Fucose_isomerase_dom2_sf. IPR009015. Fucose_isomerase_N/cen_sf. IPR012889. Fucose_isomerase_N2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02952. Fucose_iso_C. 1 hit. PF07881. Fucose_iso_N1. 1 hit. PF07882. Fucose_iso_N2. 1 hit.
SUPFAMⁱ	SSF50443. SSF50443. 1 hit. SSF53743. SSF53743. 1 hit.
TIGRFAMsⁱ	TIGR01089. fucI. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FUCI_STRP2
Accessionⁱ	Q04I16Primary (citable) accession number: Q04I16
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	November 14, 2006
	Last modified:	March 28, 2018
	This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q04I16 (FUCI_STRP2)

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L-fucose isomerase

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-fucose degradation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: L-fucose degradation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ