UniProtKB - Q04I16 (FUCI_STRP2)
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Protein
L-fucose isomerase
Gene
fucI
Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Functioni
Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation
Catalytic activityi
L-fucopyranose = L-fuculose.UniRule annotation
Cofactori
Mn2+UniRule annotation
: L-fucose degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- L-fucose isomerase (fucI)
- no protein annotated in this organism
- no protein annotated in this organism
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 335 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 335 | ManganeseUniRule annotation | 1 | |
Active sitei | 359 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 359 | ManganeseUniRule annotation | 1 | |
Metal bindingi | 525 | ManganeseUniRule annotation | 1 |
GO - Molecular functioni
- L-fucose isomerase activity Source: UniProtKB-EC
- manganese ion binding Source: InterPro
GO - Biological processi
- fucose catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Isomerase |
Biological process | Carbohydrate metabolism, Fucose metabolism |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00563; UER00624. |
Names & Taxonomyi
Protein namesi | Recommended name: L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)Alternative name(s): 6-deoxy-L-galactose isomeraseUniRule annotation FucIase |
Gene namesi | Name:fucIUniRule annotation Ordered Locus Names:SPD_1986 |
Organismi | Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) |
Taxonomic identifieri | 373153 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000067227 | 1 – 588 | L-fucose isomeraseAdd BLAST | 588 |
Structurei
3D structure databases
ProteinModelPortali | Q04I16. |
SMRi | Q04I16. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the L-fucose isomerase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105EHF. Bacteria. COG2407. LUCA. |
HOGENOMi | HOG000249674. |
KOi | K01818. |
OMAi | HAQKGLP. |
Family and domain databases
Gene3Di | 3.20.14.10. 1 hit. 3.40.275.10. 1 hit. 3.40.50.1070. 1 hit. |
HAMAPi | MF_01254. Fucose_iso. 1 hit. |
InterProi | View protein in InterPro IPR004216. Fuc/Ara_isomerase_C. IPR038393. Fuc_iso_dom3_sf. IPR015888. Fuc_isomerase_C. IPR038391. Fucose_iso_dom1_sf. IPR012888. Fucose_iso_N1. IPR005763. Fucose_isomerase. IPR038392. Fucose_isomerase_dom2_sf. IPR009015. Fucose_isomerase_N/cen_sf. IPR012889. Fucose_isomerase_N2. |
Pfami | View protein in Pfam PF02952. Fucose_iso_C. 1 hit. PF07881. Fucose_iso_N1. 1 hit. PF07882. Fucose_iso_N2. 1 hit. |
SUPFAMi | SSF50443. SSF50443. 1 hit. SSF53743. SSF53743. 1 hit. |
TIGRFAMsi | TIGR01089. fucI. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q04I16-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP
60 70 80 90 100
VECVISPSTI GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD
110 120 130 140 150
IPHAIWGFNG TERPGAVYLA AVLASHAQKG IPAFGIYGRD VQEASDTAIP
160 170 180 190 200
EDVKEKLLRY ARAALATGLM RDTAYLSMGS VSMGIGGSIV NPDFFQEYLG
210 220 230 240 250
MRNESVDMTE FTRRMDRGIY DPEEFERALK WVKENVKEGF DHNREDLVLS
260 270 280 290 300
REEKDRQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ
310 320 330 340 350
RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL
360 370 380 390 400
TNTPQIFADV RTYWSPEAVE RVTGYTLEGR AAAGFLHLIN SGSCTLDGTG
410 420 430 440 450
QATRDGKPVM KPFWELDESE VQAMLENTDF PPANREYFRG GGFSTRFLTK
460 470 480 490 500
GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL PEDVHHTLDN RTDPGWPTTW
510 520 530 540 550
FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL ASMLRIPVNM
560 570 580
HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000410 Genomic DNA. Translation: ABJ54752.1. |
RefSeqi | WP_000614258.1. NC_008533.1. |
Genome annotation databases
EnsemblBacteriai | ABJ54752; ABJ54752; SPD_1986. |
KEGGi | spd:SPD_1986. |
Similar proteinsi
Entry informationi
Entry namei | FUCI_STRP2 | |
Accessioni | Q04I16Primary (citable) accession number: Q04I16 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | November 14, 2006 | |
Last modified: | March 28, 2018 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |