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UniProtKB - Q04I16 (FUCI_STRP2)

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Protein

L-fucose isomerase

Gene

fucI

Organism
Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei335Proton acceptorUniRule annotation1
Metal bindingi335ManganeseUniRule annotation1
Active sitei359Proton acceptorUniRule annotation1
Metal bindingi359ManganeseUniRule annotation1
Metal bindingi525ManganeseUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Fucose metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:SPD_1986
OrganismiStreptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
Taxonomic identifieri373153 [NCBI]
Taxonomic lineageiBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›
Proteomesi
  • UP000001452 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000672271 – 588L-fucose isomeraseAdd BLAST588

Interactioni

Protein-protein interaction databases

STRINGi373153.SPD_1986.

Structurei

3D structure databases

ProteinModelPortaliQ04I16.
SMRiQ04I16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EHF. Bacteria.
COG2407. LUCA.
HOGENOMiHOG000249674.
KOiK01818.
OMAiGAISYGH.

Family and domain databases

HAMAPiMF_01254. Fucose_iso. 1 hit.
InterProiView protein in InterPro
IPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
PfamiView protein in Pfam
PF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q04I16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP 
        60         70         80         90        100
VECVISPSTI GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD 
       110        120        130        140        150
IPHAIWGFNG TERPGAVYLA AVLASHAQKG IPAFGIYGRD VQEASDTAIP 
       160        170        180        190        200
EDVKEKLLRY ARAALATGLM RDTAYLSMGS VSMGIGGSIV NPDFFQEYLG 
       210        220        230        240        250
MRNESVDMTE FTRRMDRGIY DPEEFERALK WVKENVKEGF DHNREDLVLS 
       260        270        280        290        300
REEKDRQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ 
       310        320        330        340        350
RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL 
       360        370        380        390        400
TNTPQIFADV RTYWSPEAVE RVTGYTLEGR AAAGFLHLIN SGSCTLDGTG 
       410        420        430        440        450
QATRDGKPVM KPFWELDESE VQAMLENTDF PPANREYFRG GGFSTRFLTK 
       460        470        480        490        500
GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL PEDVHHTLDN RTDPGWPTTW 
       510        520        530        540        550
FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL ASMLRIPVNM 
       560        570        580 
HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK
Length:588
Mass (Da):65,850
Last modified:November 14, 2006 - v1
Checksum:i4C114F7C5D67D559
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ54752.1.
RefSeqiWP_000614258.1. NC_008533.1.

Genome annotation databases

EnsemblBacteriaiABJ54752; ABJ54752; SPD_1986.
KEGGispd:SPD_1986.
PATRICi19685306. VBIStrPne27904_2134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000410 Genomic DNA. Translation: ABJ54752.1.
RefSeqiWP_000614258.1. NC_008533.1.

3D structure databases

ProteinModelPortaliQ04I16.
SMRiQ04I16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi373153.SPD_1986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ54752; ABJ54752; SPD_1986.
KEGGispd:SPD_1986.
PATRICi19685306. VBIStrPne27904_2134.

Phylogenomic databases

eggNOGiENOG4105EHF. Bacteria.
COG2407. LUCA.
HOGENOMiHOG000249674.
KOiK01818.
OMAiGAISYGH.

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Family and domain databases

HAMAPiMF_01254. Fucose_iso. 1 hit.
InterProiView protein in InterPro
IPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
PfamiView protein in Pfam
PF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUCI_STRP2
AccessioniPrimary (citable) accession number: Q04I16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: May 10, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.