Reviewed, UniProtKB/Swiss-Prot Q04I16 (FUCI_STRP2)

Names and origin

Protein names

Recommended name:
    L-fucose isomerase
    EC=5.3.1.25
Alternative name(s):
    6-deoxy-L-galactose isomerase
    FucIase

Gene names

Name:	fucI
Ordered Locus Names:	SPD_1986

Organism

Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) [Complete proteome] [HAMAP]

Taxonomic identifier

373153 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	588 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Converts the aldose L-fucose into the corresponding ketose L-fuculose By similarity.
Catalytic activity	L-fucose = L-fuculose. HAMAP MF_01254
Cofactor	Manganese By similarity.
Pathway	Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3. HAMAP MF_01254
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the L-fucose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Fucose metabolism
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fucose catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-fucose isomerase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 588	588	L-fucose isomerase HAMAP MF_01254		PRO_1000067227
Sites
	Active site	335	1	Proton acceptor By similarity
	Active site	359	1	Proton acceptor By similarity
	Metal binding	335	1	Manganese By similarity
	Metal binding	359	1	Manganese By similarity
	Metal binding	525	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q04I16-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 4C114F7C5D67D559	FASTA	588	65,850
	10 20 30 40 50 60 MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP VECVISPSTI 70 80 90 100 110 120 GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD IPHAIWGFNG TERPGAVYLA 130 140 150 160 170 180 AVLASHAQKG IPAFGIYGRD VQEASDTAIP EDVKEKLLRY ARAALATGLM RDTAYLSMGS 190 200 210 220 230 240 VSMGIGGSIV NPDFFQEYLG MRNESVDMTE FTRRMDRGIY DPEEFERALK WVKENVKEGF 250 260 270 280 290 300 DHNREDLVLS REEKDRQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ 310 320 330 340 350 360 RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL TNTPQIFADV 370 380 390 400 410 420 RTYWSPEAVE RVTGYTLEGR AAAGFLHLIN SGSCTLDGTG QATRDGKPVM KPFWELDESE 430 440 450 460 470 480 VQAMLENTDF PPANREYFRG GGFSTRFLTK GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL 490 500 510 520 530 540 PEDVHHTLDN RTDPGWPTTW FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL 550 560 570 580 ASMLRIPVNM HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK

References

[1]

"Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6." Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E. J. Bacteriol. 189:38-51(2007) [PubMed: 17041037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000410 Genomic DNA. Translation: ABJ54752.1.
RefSeq	YP_817372.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4442576.
GenomeReviews	Gene locus SPD_1986 in contig CP000410_GR.
KEGG	spd:SPD_1986.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q04I16. TWFVPRL.
Family and domain databases
HAMAP	MF_01254. [Tree]
InterPro	IPR015888. Fuc_isomerase-like_C. IPR004216. Fuc_isomerase_C. IPR012888. Fucose_iso_N1. IPR005763. Fucose_isomerase. IPR012889. Fucose_isomerase_N2. [Graphical view]
Gene3D	G3DSA:3.20.14.10. Fuc_isomerase_C. 1 hit. G3DSA:3.40.50.1070. Fucose_iso_N1. 1 hit. G3DSA:3.40.275.10. Fucose_iso_N2. 1 hit.
Pfam	PF02952. Fucose_iso_C. 1 hit. PF07881. Fucose_iso_N1. 1 hit. PF07882. Fucose_iso_N2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01089. fucI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FUCI_STRP2

Accession

Primary (citable) accession number: Q04I16

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 14, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)