Reviewed, UniProtKB/Swiss-Prot Q04HZ7 (DLTA_STRP2)

Names and origin

Protein names

Recommended name:
    D-alanine--poly(phosphoribitol) ligase subunit 1
    EC=6.1.1.13
Alternative name(s):
    D-alanine-activating enzyme
      Short name=DAE
    D-alanine-D-alanyl carrier protein ligase
      Short name=DCL

Gene names

Name:	dltA
Ordered Locus Names:	SPD_2005

Organism

Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) [Complete proteome] [HAMAP]

Taxonomic identifier

373153 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	516 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp By similarity.
Catalytic activity	ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate). HAMAP MF_00593
Pathway	Cell wall biogenesis; lipoteichoic acid biosynthesis. HAMAP MF_00593
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	teichoic acid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW D-alanine-poly(phosphoribitol) ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 516	516	D-alanine--poly(phosphoribitol) ligase subunit 1 HAMAP MF_00593		PRO_1000025536

Sequences

	Sequence		Length	Mass (Da)
	Q04HZ7-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: C20C9E7F8EB7150B	FASTA	516	57,427
	10 20 30 40 50 60 MSNKPIADMI ETIEHFAQTQ PSYPVYNVLG QEHTYGDLKA DSDSLAAVID QLGLPEKSPV 70 80 90 100 110 120 VVFGGQEYEM LATFVALTKS GHAYIPIDSH SALERVSAIL EVAEPSLIIA ISAFPLEQVS 130 140 150 160 170 180 TPMINLAQVQ EAFAQGNNYE ITHPVKGDDN YYIIFTSGTT GKPKGVQISH DNLLSFTNWM 190 200 210 220 230 240 ITDKEFATPS RPQMLAQPPY SFDLSVMYWA PTLALGGTLF TLPSVITQDF KQLFAAIFSL 250 260 270 280 290 300 PIAIWTSTPS FADMAMLSEY FNSEKMPGIT HFYFDGEELT VKTAQKLRER FPNARIINAY 310 320 330 340 350 360 GPTEATVALS AVAVTDEMLA TLKRLPIGYT KADSPTFIID EEGNKLPNGE QGEIIVSGPA 370 380 390 400 410 420 VSKGYMNNPE KTAEAFFEFE DLPAYHTGDV GTMTDEGLLL YGGRMDFQIK FNGYRIELED 430 440 450 460 470 480 VSQNLNKSRF IESAVAVPRY NKDHKVQNLL AYVILKDGVR EQFERDIDIT KAIKEDLTDI 490 500 510 MMSYMMPSKF LYRDSLPLTP NGKIDIKGLI NEVNKR

References

[1]

"Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6." Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E. J. Bacteriol. 189:38-51(2007) [PubMed: 17041037] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000410 Genomic DNA. Translation: ABJ54767.1.
RefSeq	YP_817391.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4442941.
GenomeReviews	Gene locus SPD_2005 in contig CP000410_GR.
KEGG	spd:SPD_2005.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	Q04HZ7. AFFEFEG.
Family and domain databases
HAMAP	MF_00593. [Tree]
InterPro	IPR010071. AA_adenyl_domain. IPR000873. AMP-dep_Synth/Lig. IPR010072. D_ala_DACP_lig. [Graphical view]
PANTHER	PTHR11968:SF34. D_ala_DACP_lig. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR01733. AA-adenyl-dom. 1 hit. TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLTA_STRP2

Accession

Primary (citable) accession number: Q04HZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	June 16, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)