Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q04G13 (DDL_OENOB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:OEOE_0672
OrganismOenococcus oeni (strain ATCC BAA-331 / PSU-1) [Complete proteome] [HAMAP]
Taxonomic identifier203123 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesOenococcus

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341142

Regions

Domain137 – 346210ATP-grasp
Nucleotide binding167 – 22256ATP By similarity

Sites

Metal binding3001Magnesium or manganese 1 By similarity
Metal binding3131Magnesium or manganese 1 By similarity
Metal binding3131Magnesium or manganese 2 By similarity
Metal binding3151Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04G13 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 1CC1FB8BD9753F8A

FASTA37742,113
        10         20         30         40         50         60 
MAEKIRVGLF FGGNSSEHDV SKRSAKNYYD ALDPEKYQIF PVLISKKGIM IDSETSKRVL 

        70         80         90        100        110        120 
FGEDEDELLA GLPNKNADIF GPIDSIRNLK LDVLFPSVHG NLGEDGTLAG LFRLMNIPYV 

       130        140        150        160        170        180 
GSGLRAHAIS FDKVITKELM TVNGIRNTKY IVIFQNDKNK PDWDSVSKQL GEVVFVKAAN 

       190        200        210        220        230        240 
QGSSVGVSRV TNAEEYENAL RDSFQYDEKL LVEKAVESPT ELEIGLLGND RVITSPIGAH 

       250        260        270        280        290        300 
WAPGQDHGSG WFDYKNKFVD NSKMKYQIPA KISPAKSKEL ENMAVKAYKV LGIKGFARID 

       310        320        330        340        350        360 
FLMSKDGEIF LSEPNTLPGN TNMSLFPILF EAAGMNRSQQ AEKLIQLAFE EFKREQNISY 

       370 
SFKELGSEKL GQFDIKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000411 Genomic DNA. Translation: ABJ56609.1.
RefSeqYP_810274.1. NC_008528.1.

3D structure databases

ProteinModelPortalQ04G13.
SMRQ04G13. Positions 4-359.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203123.OEOE_0672.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ56609; ABJ56609; OEOE_0672.
GeneID4416813.
KEGGooe:OEOE_0672.
PATRIC22799489. VBIOenOen113004_0681.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycOOEN203123:GHNL-672-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_OENOB
AccessionPrimary (citable) accession number: Q04G13
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways