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Q04FS6 (FTHS_OENOB) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:OEOE_0769
OrganismOenococcus oeni (strain ATCC BAA-331 / PSU-1) [Complete proteome] [HAMAP]
Taxonomic identifier203123 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeOenococcus

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000300532

Regions

Nucleotide binding63 – 708ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q04FS6 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 5CDF80AAA4DA3EEF

FASTA55359,483
        10         20         30         40         50         60 
MKSDIEIDHS IKALPITEIG KQIGLSDSQL IPYGHDKAKI DAYSIANMPR QGKLVLVTSI 

        70         80         90        100        110        120 
NPTPAGEGKT TVTIGLVDAI NRLGKSAIGA LREPSMGPVF GLKGGATGGG YAQVIPMEDI 

       130        140        150        160        170        180 
NLHFTGDIHA VSAAHNLLAA VIDNHLHQGN ELKIDPENIY WRRVLDMNDR ALRQITLGKG 

       190        200        210        220        230        240 
RVNGPERNSG FDITASSEIM AVLTLSKNLF DLKKRLSRIV VALDVQGKPV TVADLKVAGA 

       250        260        270        280        290        300 
LTAILKDAIN PNLVQSLEHS PFIIHGGPFA NIAQGTNSVV ATDAALKLAD FAVTEAGFGS 

       310        320        330        340        350        360 
DLGGEKFMDV KVPVLGKEPD AVVIVATVKA LKFHGGVALD HLSDKNVDAV RNGLDNLNRH 

       370        380        390        400        410        420 
LEAMTHYGKP VVVALNKFLD DDMEEIQLIK NFVEGEKKLQ FEIVTSFVDG FEGSLDLAKK 

       430        440        450        460        470        480 
VIEATDNQRF FMPLYQADDS IENKIQTIVE KIYGGKDFEL SDRAKKDLAE VKENGWGKLP 

       490        500        510        520        530        540 
VVIAKTPNSL TDDSKIHGAP TGFTIHIRRF IPKIGAGFIV AMAGKVLMMP GLGKNPAAEK 

       550 
IDVDENGKIS GLS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000411 Genomic DNA. Translation: ABJ56696.1.
RefSeqYP_810361.1. NC_008528.1.

3D structure databases

ProteinModelPortalQ04FS6.
SMRQ04FS6. Positions 4-551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203123.OEOE_0769.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ56696; ABJ56696; OEOE_0769.
GeneID4416536.
KEGGooe:OEOE_0769.
PATRIC22799697. VBIOenOen113004_0783.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMANTIVQRI.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycOOEN203123:GHNL-769-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_OENOB
AccessionPrimary (citable) accession number: Q04FS6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways