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Q04FS6

- FTHS_OENOB

UniProt

Q04FS6 - FTHS_OENOB

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Oenococcus oeni (strain ATCC BAA-331 / PSU-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi63 – 708ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciOOEN203123:GHNL-769-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:OEOE_0769
    OrganismiOenococcus oeni (strain ATCC BAA-331 / PSU-1)
    Taxonomic identifieri203123 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeOenococcus
    ProteomesiUP000000774: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Formate--tetrahydrofolate ligasePRO_0000300532Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi203123.OEOE_0769.

    Structurei

    3D structure databases

    ProteinModelPortaliQ04FS6.
    SMRiQ04FS6. Positions 4-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiNTIVQRI.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q04FS6-1 [UniParc]FASTAAdd to Basket

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    MKSDIEIDHS IKALPITEIG KQIGLSDSQL IPYGHDKAKI DAYSIANMPR    50
    QGKLVLVTSI NPTPAGEGKT TVTIGLVDAI NRLGKSAIGA LREPSMGPVF 100
    GLKGGATGGG YAQVIPMEDI NLHFTGDIHA VSAAHNLLAA VIDNHLHQGN 150
    ELKIDPENIY WRRVLDMNDR ALRQITLGKG RVNGPERNSG FDITASSEIM 200
    AVLTLSKNLF DLKKRLSRIV VALDVQGKPV TVADLKVAGA LTAILKDAIN 250
    PNLVQSLEHS PFIIHGGPFA NIAQGTNSVV ATDAALKLAD FAVTEAGFGS 300
    DLGGEKFMDV KVPVLGKEPD AVVIVATVKA LKFHGGVALD HLSDKNVDAV 350
    RNGLDNLNRH LEAMTHYGKP VVVALNKFLD DDMEEIQLIK NFVEGEKKLQ 400
    FEIVTSFVDG FEGSLDLAKK VIEATDNQRF FMPLYQADDS IENKIQTIVE 450
    KIYGGKDFEL SDRAKKDLAE VKENGWGKLP VVIAKTPNSL TDDSKIHGAP 500
    TGFTIHIRRF IPKIGAGFIV AMAGKVLMMP GLGKNPAAEK IDVDENGKIS 550
    GLS 553
    Length:553
    Mass (Da):59,483
    Last modified:November 14, 2006 - v1
    Checksum:i5CDF80AAA4DA3EEF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000411 Genomic DNA. Translation: ABJ56696.1.
    RefSeqiYP_810361.1. NC_008528.1.

    Genome annotation databases

    EnsemblBacteriaiABJ56696; ABJ56696; OEOE_0769.
    GeneIDi4416536.
    KEGGiooe:OEOE_0769.
    PATRICi22799697. VBIOenOen113004_0783.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000411 Genomic DNA. Translation: ABJ56696.1 .
    RefSeqi YP_810361.1. NC_008528.1.

    3D structure databases

    ProteinModelPortali Q04FS6.
    SMRi Q04FS6. Positions 4-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203123.OEOE_0769.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ56696 ; ABJ56696 ; OEOE_0769 .
    GeneIDi 4416536.
    KEGGi ooe:OEOE_0769.
    PATRICi 22799697. VBIOenOen113004_0783.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi NTIVQRI.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci OOEN203123:GHNL-769-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-331 / PSU-1.

    Entry informationi

    Entry nameiFTHS_OENOB
    AccessioniPrimary (citable) accession number: Q04FS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3