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Q04FS6

- FTHS_OENOB

UniProt

Q04FS6 - FTHS_OENOB

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Oenococcus oeni (strain ATCC BAA-331 / PSU-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 708ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciOOEN203123:GHNL-769-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:OEOE_0769
OrganismiOenococcus oeni (strain ATCC BAA-331 / PSU-1)
Taxonomic identifieri203123 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeOenococcus
ProteomesiUP000000774: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligasePRO_0000300532Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203123.OEOE_0769.

Structurei

3D structure databases

ProteinModelPortaliQ04FS6.
SMRiQ04FS6. Positions 4-551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiNTIVQRI.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q04FS6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIEIDHS IKALPITEIG KQIGLSDSQL IPYGHDKAKI DAYSIANMPR
60 70 80 90 100
QGKLVLVTSI NPTPAGEGKT TVTIGLVDAI NRLGKSAIGA LREPSMGPVF
110 120 130 140 150
GLKGGATGGG YAQVIPMEDI NLHFTGDIHA VSAAHNLLAA VIDNHLHQGN
160 170 180 190 200
ELKIDPENIY WRRVLDMNDR ALRQITLGKG RVNGPERNSG FDITASSEIM
210 220 230 240 250
AVLTLSKNLF DLKKRLSRIV VALDVQGKPV TVADLKVAGA LTAILKDAIN
260 270 280 290 300
PNLVQSLEHS PFIIHGGPFA NIAQGTNSVV ATDAALKLAD FAVTEAGFGS
310 320 330 340 350
DLGGEKFMDV KVPVLGKEPD AVVIVATVKA LKFHGGVALD HLSDKNVDAV
360 370 380 390 400
RNGLDNLNRH LEAMTHYGKP VVVALNKFLD DDMEEIQLIK NFVEGEKKLQ
410 420 430 440 450
FEIVTSFVDG FEGSLDLAKK VIEATDNQRF FMPLYQADDS IENKIQTIVE
460 470 480 490 500
KIYGGKDFEL SDRAKKDLAE VKENGWGKLP VVIAKTPNSL TDDSKIHGAP
510 520 530 540 550
TGFTIHIRRF IPKIGAGFIV AMAGKVLMMP GLGKNPAAEK IDVDENGKIS

GLS
Length:553
Mass (Da):59,483
Last modified:November 14, 2006 - v1
Checksum:i5CDF80AAA4DA3EEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000411 Genomic DNA. Translation: ABJ56696.1.
RefSeqiYP_810361.1. NC_008528.1.

Genome annotation databases

EnsemblBacteriaiABJ56696; ABJ56696; OEOE_0769.
GeneIDi4416536.
KEGGiooe:OEOE_0769.
PATRICi22799697. VBIOenOen113004_0783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000411 Genomic DNA. Translation: ABJ56696.1 .
RefSeqi YP_810361.1. NC_008528.1.

3D structure databases

ProteinModelPortali Q04FS6.
SMRi Q04FS6. Positions 4-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203123.OEOE_0769.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ56696 ; ABJ56696 ; OEOE_0769 .
GeneIDi 4416536.
KEGGi ooe:OEOE_0769.
PATRICi 22799697. VBIOenOen113004_0783.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi NTIVQRI.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci OOEN203123:GHNL-769-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-331 / PSU-1.

Entry informationi

Entry nameiFTHS_OENOB
AccessioniPrimary (citable) accession number: Q04FS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3